Total thyroidectomy for the treatment of Hashimoto’s thyroiditis coexisting with papillary thyroid carcinoma

Kurukahvecioğlu, Osman; Taneri, Ferit; Yüksel, Osman; Aydin, Altan; Tezel, Ekmel; Onuk, Erhan

doi:10.1007/bf02848773

Cited by 56 publications

(45 citation statements)

References 20 publications

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“…Individuals with Hashimoto's thyroiditis are thought to have a higher risk of papillary thyroid cancer than patients without this diagnosis (32)(33)(34)(35). It could be hypothesized that our observations are due to Hashimoto's thyroiditis in the individuals with higher TSH concentrations.…”

Section: Jonklaas Et Almentioning

confidence: 79%

Endogenous Thyrotropin and Triiodothyronine Concentrations in Individuals with Thyroid Cancer

Jonklaas

Nsouli-Maktabi

Soldin

2008

Thyroid

113

102

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Background: Thyroid hormone suppression therapy is associated with decreased recurrence rates and improved survival in patients with differentiated thyroid cancer. Recently higher baseline thyrotropin (TSH) levels have been found to be associated with a postoperative diagnosis of differentiated thyroid cancer. Our objective was to confirm whether preoperative TSH levels were higher in patients who were diagnosed with differentiated thyroid cancer after undergoing thyroidectomy, compared with patients who were found to have benign disease. We also sought to determine whether thyroid hormone levels were lower in the patients with malignancy. Methods: The study was a retrospective analysis of a prospective study. The study setting was the General Clinical Research Center of an Academic Medical Center. Participants were 50 euthyroid patients undergoing thyroidectomy. Thyroxine, triiodothyronine (T 3 ), and TSH levels were documented in patients prior to their scheduled thyroidectomy. Following thyroidectomy, patients were divided into those with a histologic diagnosis of either differentiated thyroid cancer or benign disease. Preoperative thyroid profiles were correlated with patients' postoperative diagnoses. Results: All patients had a normal serum TSH concentration preoperatively. One-third of the group was diagnosed with thyroid cancer as a result of their thyroidectomy. These patients had a higher serum TSH level (mean ¼ 1.50 mIU=L, CI 1.22-1.78 mIU=L) than patients with benign disease (mean ¼ 1.01 mIU=mL, CI 0.84-1.18 mIU=L). There was a greater risk of having thyroid cancer in patients with TSH levels in the upper three quartiles of TSH values, compared with patients with TSH concentrations in the lowest quartile of TSH values (odd ratio ¼ 8.7, CI 2.2-33.7). Patients with a thyroid cancer diagnosis also had lower T 3 concentrations measured by liquid chromatography tandem mass spectrometry (mean ¼ 112.6 ng=dL, CI 103.8-121.4 ng=dL) than did patients with a benign diagnosis (mean 129.9 ng=dL, CI 121.4-138.4 ng=dL). Conclusion: These data confirm that higher TSH concentrations, even within the normal range, are associated with a subsequent diagnosis of thyroid cancer in individuals with thyroid abnormalities. This further supports the hypothesis that TSH stimulates the growth or development of thyroid malignancy during its early or preclinical phase. We also show for the first time that patients with thyroid cancer also have lower T 3 levels than patients with benign disease.

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Section: Jonklaas Et Almentioning

confidence: 79%

Endogenous Thyrotropin and Triiodothyronine Concentrations in Individuals with Thyroid Cancer

Jonklaas

Nsouli-Maktabi

Soldin

2008

Thyroid

113

102

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“…Eleven studies compared the occurrences of HT in PTCs and in benign thyroid diseases such as nodular hyperplasia and follicular adenoma (3,4,5,6,7,8,9,10,11,12,13). HT was found in 938 (40.5%) of 2317 PTC patients, whereas it was found in 634 (21%) of 3019 benign thyroid diseases.…”

Section: Ptc Vs Benign Lesionsmentioning

confidence: 99%

“…Gender The incidence of HT in PTCs according to gender was compared in 23 studies (3,4,5,6,7,14,15,19,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38). HT in PTCs was observed in 1677 of 7346 (23%) female patients and in 180 of 573 (11%) male patients.…”

Section: Clinicopathologic Characteristics Of Ptcs With Htmentioning

confidence: 99%

“…In addition, the clinicopathologic characteristics of PTCs with concomitant HT have not been definitely proposed (3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40). Therefore, the present meta-analysis was conducted to clarify the relationship between PTCs and histologically proven conventional HT and to investigate the clinicopathologic features of PTCs with coexistent HT.…”

Section: Introductionmentioning

confidence: 97%

“…HT has shown a wide range of occurrence from 5 to 85% in thyroid specimens resected for PTC (3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40). In addition, the clinicopathologic characteristics of PTCs with concomitant HT have not been definitely proposed (3,4,5,6,7,8,9,10,11,12,13,14,15,…”

Section: Introductionmentioning

confidence: 99%

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The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis

Lee

Kim

Choi

et al. 2013

European Journal of Endocrinology

280

259

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Objective: No consensus exists on the association between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT). To resolve this controversy, this study aimed to evaluate the relationship between the two conditions using a meta-analysis. Methods: We searched relevant published studies using citation databases including PubMed, Embase, and ISI Web of Science. The effect sizes of clinicopathologic parameters were calculated by odds ratio (OR), weighted mean difference, or hazard ratio (HR). The effect sizes were combined using a randomeffects model. Results: Thirty-eight eligible studies including 10 648 PTC cases were selected. Histologically proven HT was identified in 2471 (23.2%) PTCs. HT was more frequently observed in PTCs than in benign thyroid diseases and other carcinomas (ORZ2.8 and 2.4; P!0.001). PTCs with coexisting HT were significantly related to female patients (ORZ2.7; P!0.001), multifocal involvement (ORZ1.5; PZ0.010), no extrathyroidal extension (ORZ1.3; PZ0.002), and no lymph node metastasis (ORZ1.3; PZ0.041). Moreover, PTCs with HT were significantly associated with long recurrence-free survival (HRZ0.6; PZ0.001). Conclusions: Our meta-analysis showed that PTC is significantly associated with pathologically confirmed HT. PTC patients with HT have favorable clinicopathologic characteristics compared with PTCs without HT. However, patients with HT need to be carefully monitored for the development of PTC.

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Genetic Alterations in Papillary Thyroid Carcinoma and Hashimoto Thyroiditis

Royer¹,

Zhang²,

Fan³

et al. 2010

Arch Otolaryngol Head Neck Surg

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Total thyroidectomy for the treatment of Hashimoto’s thyroiditis coexisting with papillary thyroid carcinoma

Cited by 56 publications

References 20 publications

Endogenous Thyrotropin and Triiodothyronine Concentrations in Individuals with Thyroid Cancer

Endogenous Thyrotropin and Triiodothyronine Concentrations in Individuals with Thyroid Cancer

The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis

Genetic Alterations in Papillary Thyroid Carcinoma and Hashimoto Thyroiditis

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