Total triiodothyronine level associated with disease severity for patients with emergent status

Wang, Shuxia; Chen, Mingxia; Sun, Danqun; Wang, Lei; Yao, Xiaoming; Xu, Shuhang

doi:10.1038/s41598-024-68195-z

Sci Rep

2024

DOI: 10.1038/s41598-024-68195-z

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Total triiodothyronine level associated with disease severity for patients with emergent status

Shuxia Wang,

Mingxia Chen,

Danqun Sun

et al.

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2024

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Recent advances in liquid chromatography‐tandem mass spectrometry for the detection of thyroid hormones and thyroglobulin in clinical samples: A review

Jin,

Zhai,

Wang

et al. 2024

J of Separation Science

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Thyroid hormones (THs), including triiodothyronine (T3), thyroxine (T4), and their metabolites, are essential for regulating development, growth, and energy metabolism. Thyroglobulin (Tg) produced by thyroid follicular cells acts as an essential substrate for TH synthesis. The combination of THs with Tg is a widely used serological laboratory test for thyroid function assessment. Early detection and timely intervention are significant for preventing and managing thyroid disease. In recent years, liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) has emerged as a powerful tool for the precise detection of small molecular analytes and steroid hormones in clinical practice as a result of its high sensitivity and specificity. While LC‐MS/MS has been increasingly used for detecting THs and Tg recently, its application in clinical practice is still in its early stages. Recent advances in the assessment of thyroid metabolism using LC‐MS/MS in clinical samples published during 2004–2023 were reviewed, with a special focus on the use of this technique for quantifying molecules involved in thyroid diseases.

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Recent advances in liquid chromatography‐tandem mass spectrometry for the detection of thyroid hormones and thyroglobulin in clinical samples: A review

Jin,

Zhai,

Wang

et al. 2024

J of Separation Science

View full text Add to dashboard Cite

show abstract

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Total triiodothyronine level associated with disease severity for patients with emergent status

Cited by 1 publication

References 20 publications

Recent advances in liquid chromatography‐tandem mass spectrometry for the detection of thyroid hormones and thyroglobulin in clinical samples: A review

Recent advances in liquid chromatography‐tandem mass spectrometry for the detection of thyroid hormones and thyroglobulin in clinical samples: A review

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