Tourniquet Constriction Exacerbates Hyperalgesia-related Pain Induced by Intradermal Capsaicin Injection

Byas-Smith, Michael G.; Bennett, Gary J.; Gracely, Richard H.; Max, Mitchell B.; Robinovitz, Elaine; Dubner, Ronald

doi:10.1097/00000542-199909000-00010

Cited by 17 publications

(12 citation statements)

References 16 publications

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“…The upper extremity was used in these control experiments for technical reasons, but it is unlikely that different results would have been obtained by using the lower extremities. In contrast to our results, Byas‐Smith et al11 reported increased pain sensation by tourniquet constriction after cutaneous application of capsaicin. Drummond 13 also found increased thermal hyperalgesia in the skin during tourniquet constriction after topical capsaicin application.…”

Section: Discussioncontrasting

confidence: 99%

“…The different findings are possibly due to different methodical approaches. Byas‐Smith et al11 injected capsaicin intradermally and the increased pain seemed to be related to the development of secondary hyperalgesia. Similar to our results showing no significant change in pain during tourniquet constriction within the range of 10 mmHg, they11 also found no significant increase in pain at a tourniquet pressure of between 100 and 150 mmHg.…”

Section: Discussionmentioning

confidence: 99%

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Effect of sympathetic muscle vasoconstrictor activity on capsaicin‐induced muscle pain

Wasner¹,

Bréchôt²,

Schattschneider³

et al. 2002

Muscle and Nerve

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Neuropathic pain syndromes with sympathetically maintained pain are often associated with a deep somatic pain component. An adrenergic interaction between sympathetic vasoconstrictor neurons and cutaneous afferents has been demonstrated. To determine whether a sympathetic-afferent interaction exists in deep somatic tissues, we investigated the effect of sympathetic muscle vasoconstrictor activity on experimentally induced pain. In 12 healthy volunteers, capsaicin was infused into the anterior tibial muscle. Intensity and quality of muscle and referred pain were assessed. The analyses were performed during the presence of low sympathetic muscle vasoconstrictor activity induced by breathing 100% O(2) gas (normocapnia), and during high activity induced by inspiration of 95% O(2) and 5% CO(2) (hypercapnia). The degree of sympathetic muscle vasoconstrictor discharge was monitored indirectly by measuring systemic blood pressure and end-expiratory CO(2) and by performing duplex sonography of muscle resistance vessels. The intensity, quality, and spatial distribution of muscle and referred pain were not significantly different during resting and increased sympathetic muscle vasoconstrictor discharge, indicating that such activity does not influence pain after intramuscular infusion of capsaicin.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of sympathetic muscle vasoconstrictor activity on capsaicin‐induced muscle pain

Wasner¹,

Bréchôt²,

Schattschneider³

et al. 2002

Muscle and Nerve

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“…However, intradermal injections of capsaicin always evoked only pain, typically described as burning or stinging [1,13]. The localized pain began immediately upon injection, peaked within a minute later, then gradually declined.…”

Section: Discussionmentioning

confidence: 99%

Behavioral differentiation between itch and pain in mouse

Shimada¹,

LaMotte²

2008

Pain

331

336

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The standard rodent model of itch uses scratching with the hind limb as a behavioral response to pruritic stimuli applied to the nape of the neck. The assumption is that scratching is an indicator of the sensation of itch. But because only one type of site-directed behavior is available, one cannot be certain that scratching is not a response to nociceptive or other qualities of sensations in addition to, or instead of, itch. To extend the model, we administered chemical stimuli to the cheek of the mouse and counted scratching with the hind limb as an indicator of itch and wiping with the forelimb as an indicator of pain. An intradermal injection of histamine and capsaicin, known to evoke predominantly itch and pain, respectively, in humans, each elicited hind limb scratching behavior when injected into the nape of the neck of the mouse. In contrast, when the same chemicals were injected into the cheek of the mouse, there were two site-directed behaviors: histamine again elicited scratching with the hind limb, but capsaicin evoked wiping with the forelimb. We conclude that the “cheek model of itch” in the mouse provides a behavioral differentiation of chemicals that elicit predominantly itch in humans from those that evoke nociceptive sensations. That is, the model provides a behavioral differentiation between itch and pain in the mouse.

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“…Kompression durch Manschettendruck hat sich bei Menschenversuchen an Freiwilligen als sicheres Mittel zur Schmerzverschlimmerung erwiesen [8]. Beim akuten Kompartmentsyndrom, einer häufigen Komplikation von Unterschenkelfrakturen und Quetschverletzungen, führt das Leitsymptom "Schmerz" zuerst zur Diagnoe [2].…”

Section: Schmerzursacheunclassified

Linderung chronischer Schmerzzust�nde durch freien Gewebstransfer

Rieck

Svoboda

Giesler

2004

Schmerz

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We report on two patients with chronic pain syndrome of a lower limb due to chronic constriction after radiation therapy in one case and to popliteal entrapment in the other. The patients had been in pain therapy for years and had achieved insufficient analgesia in one case and satisfactory analgesia in another case with high doses of morphine sulphate and other medication. Surgery was indicated for limb salvage in one patient, and for pain relief in the other patient. It consisted of decompression and defect reconstruction by free latissimus dorsi flaps. In both cases, after an uncomplicated follow-up, quick and complete weaning from the analgesics was possible. One of the patients is completely free of pain.

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Tourniquet Constriction Exacerbates Hyperalgesia-related Pain Induced by Intradermal Capsaicin Injection

Abstract: Low cutaneous blood perfusion is related to the intensity of ongoing, spontaneous pain when secondary hyperalgesia is present. The specific trigger(s) have yet to be identified.

Cited by 17 publications

References 16 publications

Effect of sympathetic muscle vasoconstrictor activity on capsaicin‐induced muscle pain

Effect of sympathetic muscle vasoconstrictor activity on capsaicin‐induced muscle pain

Behavioral differentiation between itch and pain in mouse

Linderung chronischer Schmerzzust�nde durch freien Gewebstransfer

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