Toward a highly hemocompatible membrane for blood purification via a physical blend of miscible comb-like amphiphilic copolymers

Bionic design for surface optimization combining hydrophilic and negative charged biological macromolecules

“…Besides contributing to the blood compatibility, the amphiphilic block copolymer PVMV also dramatically affected the migration and self-assembly of the additives during phase separation process. After blending with the additives contained -PVP chains, the modified membranes showed smooth, regular and well-surfacesegregated surface [2,28]; otherwise, after blending the additives without -PVP chains, the modified membranes seemed somewhat irregular and not-well-surface-segregated [16]. However, it is not easy to introduce -PVP chains into ionic block copolymer [29,30].…”

“…It was found that the blood clotting time of the modified PES membranes increased compared with the pristine PES membranes and the APTT It can be obviously seen that both the functional chains of PVP and PSS have significant contribution to the blood clotting time. For the effect of PVP brushes, the enhancement in anticoagulant activity might resulted from partial contributions of surface hydrophilicity, and thus the lower protein adsorption and depressed platelet adhesion and activation [2,28]. For the effect of PSS brushes, there may be a repulsive interaction between the negatively charged groups with some blood coagulation factors.…”

“…It is well known that polymeric materials are widely used in the field of blood purification [1][2][3], but most of them would influence coagulant system by different levels when contact with blood. Poor blood compatibility may result in thrombogenic formation, response of immune system, or other tissue responses [4].…”

Overview of PES biocompatible/hemodialysis membranes: PES–blood interactions and modification techniques

“…[70] APTT increased from 58 to 93 s. [165] a For rejection PEG 10 K solution was used instead of BSA solution. [50], plasma induced grafting and plasma treatment [51,52], thermal induced immobilization and grafting [30,53], and surface-initiatedatom-transfer-radical polymerization [54][55][56][57].…”

Heparin-Mimicking Multilayer Coating on Polymeric Membrane via LbL Assembly of Cyclodextrin-Based Supramolecules

“…3,[12][13][14][15][16] Meanwhile, these studies have confirmed that the heparinmimicking methods could improve the blood compatibility and extend the potential applications of the biomedical materials. However, to design the next generation multifunctional biomedical membranes, the heparin-like linear polymers are insufficient to meet the challenges required for multi-functionality with tunable surface morphologies along with extended biological activity.…”