Toward a Scientific Nutritional Supplement Combination for Prostatism and Erectile Dysfunction I: From Known Pharmacology to Clinical Testing

Pyke, Robert E.

doi:10.1089/jmf.2018.0148

Cited by 2 publications

(2 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evidence Limited information derived from observational studies have suggested an association between reduced circulating levels of vitamin D and ED either in the general population [274,275] or T2DM [276]. Similar observation has been reported for L-citrulline, beta-sitosterol, ginseng [275] and tribulus terrestris [274,277]. Putative working mechanisms of actions include stimulation of nitric oxide pathway, antiinflammatory effects, or T secretion enhancement.…”

Section: Nutritional Supplementsmentioning

confidence: 64%

“…Limited information derived from observational studies have suggested an association between reduced circulating levels of vitamin D and ED either in the general population [ 274 , 275 ] or T2DM [ 276 ]. Similar observation has been reported for L-citrulline, beta-sitosterol, ginseng [ 275 ] and tribulus terrestris [ 274 , 277 ]. Putative working mechanisms of actions include stimulation of nitric oxide pathway, anti-inflammatory effects, or T secretion enhancement.…”

Section: Symptomatic Therapiesmentioning

confidence: 99%

See 1 more Smart Citation

The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction

Corona

Cucinotta

Lorenzo

et al. 2023

J Endocrinol Invest

View full text Add to dashboard Cite

Purpose Erectile dysfunction (ED) is one of the most prevalent male sexual dysfunctions. ED has been in the past mistakenly considered a purely psycho-sexological symptom by patients and doctors. However, an ever-growing body of evidence supporting the role of several organic factors in the pathophysiological mechanisms underlying ED has been recognized. Methods The Italian Society of Andrology and Sexual Medicine (SIAMS) commissioned an expert task force involving several other National Societies to provide an updated guideline on the diagnosis and management of ED. Derived recommendations were based on the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system. Results Several evidence-based statements were released providing the necessary up-to-date guidance in the context of ED with organic and psychosexual comorbidities. Many of them were related to incorrect lifestyle habits suggesting how to associate pharmacotherapies and counseling, in a couple-centered approach. Having the oral therapy with phosphodiesterase type 5 inhibitors as the gold standard along with several other medical and surgical therapies, new therapeutic or controversial options were also discussed. Conclusions These are the first guidelines based on a multidisciplinary approach that involves the most important Societies related to the field of sexual medicine. This fruitful discussion allowed for a general agreement on several recommendations and suggestions to be reached, which can support all stakeholders in improving couple sexual satisfaction and overall general health. Supplementary Information The online version contains supplementary material available at 10.1007/s40618-023-02015-5.

show abstract