Toward a Synthesis of Cellular Auditory Forebrain Functional Organization

Winer, Jeffery A.; Schreiner, Christoph E.

doi:10.1007/978-1-4419-0074-6_32

Cited by 16 publications

(18 citation statements)

References 112 publications

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“…Nevertheless, because we used relatively small deposits of tracer, the callosal labeling was often sparse. A full appreciation of the complexities of callosal labeling frequently observed in the auditory cortex (Hackett and Philipps, 2011), for each of the cortical fields under consideration here, requires additional experiments utilizing larger deposits of tracer.…”

Section: Discussionmentioning

confidence: 99%

Cortico‐cortical connectivity within ferret auditory cortex

Bizley

Bajo

Nodal³

et al. 2015

J of Comparative Neurology

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Despite numerous studies of auditory cortical processing in the ferret (Mustela putorius), very little is known about the connections between the different regions of the auditory cortex that have been characterized cytoarchitectonically and physiologically. We examined the distribution of retrograde and anterograde labeling after injecting tracers into one or more regions of ferret auditory cortex. Injections of different tracers at frequency‐matched locations in the core areas, the primary auditory cortex (A1) and anterior auditory field (AAF), of the same animal revealed the presence of reciprocal connections with overlapping projections to and from discrete regions within the posterior pseudosylvian and suprasylvian fields (PPF and PSF), suggesting that these connections are frequency specific. In contrast, projections from the primary areas to the anterior dorsal field (ADF) on the anterior ectosylvian gyrus were scattered and non‐overlapping, consistent with the non‐tonotopic organization of this field. The relative strength of the projections originating in each of the primary fields differed, with A1 predominantly targeting the posterior bank fields PPF and PSF, which in turn project to the ventral posterior field, whereas AAF projects more heavily to the ADF, which then projects to the anteroventral field and the pseudosylvian sulcal cortex. These findings suggest that parallel anterior and posterior processing networks may exist, although the connections between different areas often overlap and interactions were present at all levels. J. Comp. Neurol. 523:2187–2210, 2015. © 2015 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Cortico‐cortical connectivity within ferret auditory cortex

Bizley

Bajo

Nodal³

et al. 2015

J of Comparative Neurology

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“…Although a hierarchy of cortical areas has been described in the neuroanatomy of the mammalian auditory system (Hackett, 2011; Winer and Schreiner, 2010), there has been less progress in elucidating the functional role of different cortical areas in this hierarchy. Studies in the visual system have suggested that the activity of neurons in higher areas in the sensory processing hierarchy shows a greater influence of attention during task performance (Kastner and Pinsk, 2004; Maunsell and Cook, 2002).…”

Section: Introductionmentioning

confidence: 99%

Emergent Selectivity for Task-Relevant Stimuli in Higher-Order Auditory Cortex

Atiani

David

Elgueda

et al. 2014

Neuron

144

166

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A variety of attention-related effects have been demonstrated in primary auditory cortex (A1). However, an understanding of the functional role of higher auditory cortical areas in guiding attention to acoustic stimuli has been elusive. We recorded from neurons in two tonotopic cortical belt areas in the dorsal posterior ectosylvian gyrus (dPEG) of ferrets trained on a simple auditory discrimination task. Neurons in dPEG showed similar basic auditory tuning properties to A1, but during behavior we observed marked differences between these areas. In the belt areas, changes in neuronal firing rate and response dynamics greatly enhanced responses to target stimuli relative to distractors, allowing for greater attentional selection during active listening. Consistent with existing anatomical evidence, the pattern of sensory tuning and behavioral modulation in auditory belt cortex links the spectro-temporal representation of the whole acoustic scene in A1 to a more abstracted representation of task-relevant stimuli observed in frontal cortex.

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“…In particular, the expression of PNNs in the auditory mid- and forebrain of the mouse is of interest, given their essential roles in the higher order processing of auditory information [ 22 , 23 , 24 , 25 ]. The inferior colliculus (IC) is a major hub for both ascending, descending and lateral information [ 22 , 26 , 27 ], while the thalamic reticular nucleus (TRN) is the principal source of inhibition to the auditory thalamus, medial geniculate body (MGB), in mice and other rodents, where inhibitory neurons are nearly non-existent [ 28 , 29 ] and where no WFA-labeled PNNs were found in our study.…”

Section: Introductionmentioning

confidence: 99%

“…The inferior colliculus (IC) is a major hub for both ascending, descending and lateral information [ 22 , 26 , 27 ], while the thalamic reticular nucleus (TRN) is the principal source of inhibition to the auditory thalamus, medial geniculate body (MGB), in mice and other rodents, where inhibitory neurons are nearly non-existent [ 28 , 29 ] and where no WFA-labeled PNNs were found in our study. The primary auditory cortex (A1) is the upstream target for ascending auditory information [ 23 , 30 , 31 , 32 ]. Consequently, characterizing the degree of expression and distribution of PNNs in these central auditory neural structures of the mouse will further enable defining their distinct roles in auditory information processing.…”

Section: Introductionmentioning

confidence: 99%

Wisteria Floribunda Agglutinin-Labeled Perineuronal Nets in the Mouse Inferior Colliculus, Thalamic Reticular Nucleus and Auditory Cortex

et al. 2016

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Perineuronal nets (PNNs) are specialized extracellular matrix molecules that are associated with the closing of the critical period, among other functions. In the adult brain, PNNs surround specific types of neurons, however the expression of PNNs in the auditory system of the mouse, particularly at the level of the midbrain and forebrain, has not been fully described. In addition, the association of PNNs with excitatory and inhibitory cell types in these structures remains unknown. Therefore, we sought to investigate the expression of PNNs in the inferior colliculus (IC), thalamic reticular nucleus (TRN) and primary auditory cortex (A1) of the mouse brain by labeling with wisteria floribunda agglutinin (WFA). To aid in the identification of inhibitory neurons in these structures, we employed the vesicular GABA transporter (VGAT)-Venus transgenic mouse strain, which robustly expresses an enhanced yellow-fluorescent protein (Venus) natively in nearly all gamma-amino butyric acid (GABA)-ergic inhibitory neurons, thus enabling a rapid and unambiguous assessment of inhibitory neurons throughout the nervous system. Our results demonstrate that PNNs are expressed throughout the auditory midbrain and forebrain, but vary in their local distribution. PNNs are most dense in the TRN and least dense in A1. Furthermore, PNNs are preferentially associated with inhibitory neurons in A1 and the TRN, but not in the IC of the mouse. These data suggest regionally specific roles for PNNs in auditory information processing.

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Toward a Synthesis of Cellular Auditory Forebrain Functional Organization

Cited by 16 publications

References 112 publications

Cortico‐cortical connectivity within ferret auditory cortex

Cortico‐cortical connectivity within ferret auditory cortex

Emergent Selectivity for Task-Relevant Stimuli in Higher-Order Auditory Cortex

Wisteria Floribunda Agglutinin-Labeled Perineuronal Nets in the Mouse Inferior Colliculus, Thalamic Reticular Nucleus and Auditory Cortex

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