Toward Dosing Precision and Insulin Stability in an Artificial Pancreas System

Iacovacci, Veronica; Tamadon, Izadyar; Rocchi, M.; Dario, P.; Menciassi, Arianna

doi:10.1115/1.4042459

Cited by 8 publications

(17 citation statements)

References 41 publications

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“…The needle is connected to the reservoir through a medical-grade silicone tube. The reservoir is a variable volume Nylon system ( 23 ) provided with a linearly actuated plunger (fig. S4A).…”

Section: Resultsmentioning

confidence: 99%

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A fully implantable device for intraperitoneal drug delivery refilled by ingestible capsules

et al. 2021

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Creating fully implantable robots that replace or restore physiological processes is a great challenge in medical robotics. Restoring blood glucose homeostasis in patients with type 1 diabetes is particularly interesting in this sense. Intraperitoneal insulin delivery could revolutionize type 1 diabetes treatment. At present, the intraperitoneal route is little used because it relies on accessing ports connecting intraperitoneal catheters to external reservoirs. Drug-loaded pills transported across the digestive system to refill an implantable reservoir in a minimally invasive fashion could open new possibilities in intraperitoneal delivery. Here, we describe PILLSID (PILl-refiLled implanted System for Intraperitoneal Delivery), a fully implantable robotic device refillable through ingestible magnetic pills carrying drugs. Once refilled, the device acts as a programmable microinfusion system for precise intraperitoneal delivery. The robotic device is grounded on a combination of magnetic switchable components, miniaturized mechatronic elements, a wireless powering system, and a control unit to implement the refilling and control the infusion processes. In this study, we describe the PILLSID prototyping. The device key blocks are validated as single components and within the integrated device at the preclinical level. We demonstrate that the refilling mechanism works efficiently in vivo and that the blood glucose level can be safely regulated in diabetic swine. The device weights 165 grams and is 78 millimeters by 63 millimeters by 35 millimeters, comparable with commercial implantable devices yet overcoming the urgent critical issues related to reservoir refilling and powering.

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Section: Resultsmentioning

confidence: 99%

“…This structure also enables to create a negative pressure in the reservoir upon plunger pullout so as to facilitate fluid aspiration from the needle. A cylindrical reservoir featured by a conical-shaped terminal part was fabricated from Nylon 6 to not hamper insulin stability ( 23 ). The reservoir (fig.…”

Section: Methodsmentioning

confidence: 99%

A fully implantable device for intraperitoneal drug delivery refilled by ingestible capsules

et al. 2021

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“…The Archimedes screw concept has been applied and patented in other pharmaceutical ADM. 79,80 Besides, 3D printing is also used to fabricate the gear mechanisms as shown in Figure 5. Furthermore, Iacovacci et al 68 used 3D printing to produce the case for the ADM. Nylon 6 is used as the raw material due to the suitability of Nylon 6 that favours insulin stability.…”

Section: Fabrication Methodsmentioning

confidence: 99%

“…Figure 5 shows two different gear pumps that are designed via CAD and then finalized after undergoing several evaluations. 68 A pickup mechanism for an ADM such as the pill tray and linear actuator also can be designed by using CAD. 69 As mentioned previously, simulation analysis is important in predicting the reaction and capability of the device to withstand the forces or stresses introduced.…”

Section: Design and Analysismentioning

confidence: 99%

Design and development of automated dispensing machine as medical device-based application: A review

Mazlan

Salleh

Karim

et al. 2022

Proceedings of the Institution of Mechanical Engineers, Part C:

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An automatic system in equipment can be recognized as a systematic control system to minimize human tasks or automatically complete repetitive tasks without human involvement. This review paper focused on the dispensing machines in the medical field particularly the design development of the automated dispensing machines which can be considered as one of the important technologies in pharmacy. This paper also briefly describes the main criteria for fabricating the dispensing machine. Next, different fabrication methods of the dispensing machine such as simple fabrication and 3D printing as well as the materials used in 3D printing are also thoroughly discussed. The last section consisted of the evaluation methods to justify the developed devices by comparing the performance of fabricated products and also through surveys and feedback from patients and medical staff. Based on the performance evaluation of automated dispensing machines as reported in the literature, it can be concluded that the implementation of an automated dispensing machine is necessary for the high-quality guarantee of community healthcare.

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“…Combining these pumps with glucose sensors could lead to a fully implanted artificial pancreas [ 101 ]. As with all implants there remain issues of safety and long-term stability.…”

Section: Micropumpsmentioning

confidence: 99%

In-Vivo Microsystems: A Review

French

2020

Sensors

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In-vivo sensors yield valuable medical information by measuring directly on the living tissue of a patient. These devices can be surface or implant devices. Electrical activity in the body, from organs or muscles can be measured using surface electrodes. For short term internal devices, catheters are used. These include cardiac catheter (in blood vessels) and bladder catheters. Due to the size and shape of the catheters, silicon devices provided an excellent solution for sensors. Since many cardiac catheters are disposable, the high volume has led to lower prices of the silicon sensors. Many catheters use a single sensor, but silicon offers the opportunity to have multi sensors in a single catheter, while maintaining small size. The cardiac catheter is usually inserted for a maximum of 72 h. Some devices may be used for a short-to-medium period to monitor parameters after an operation or injury (1–4 weeks). Increasingly, sensing, and actuating, devices are being applied to longer term implants for monitoring a range of parameters for chronic conditions. Devices for longer term implantation presented additional challenges due to the harshness of the environment and the stricter regulations for biocompatibility and safety. This paper will examine the three main areas of application for in-vivo devices: surface devices and short/medium-term and long-term implants. The issues of biocompatibility and safety will be discussed.

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Toward Dosing Precision and Insulin Stability in an Artificial Pancreas System

Cited by 8 publications

References 41 publications

A fully implantable device for intraperitoneal drug delivery refilled by ingestible capsules

A fully implantable device for intraperitoneal drug delivery refilled by ingestible capsules

Design and development of automated dispensing machine as medical device-based application: A review

In-Vivo Microsystems: A Review

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