Toward the individual approach to the evaluation of risks and prevention of postoperative venous thromboembolism

Lobastov, Kirill; Barinov, Victor; Laberko, Leonid

doi:10.17116/flebo20159141-50

Cited by 3 publications

(1 citation statement)

References 102 publications

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“…В отсутствие адекватной фармакологической профилактики частота развития бессимптомного венозного тромбоза может достигать 50-60 % [14], а фатальной ТЭЛА -1-5 % [15]. Однако даже на фоне использования стандартных методов первичной профилактики ВТЭО средняя частота регистрации осложнений составляет 16 % [16].…”

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Treatment and secondary prevention of venous thromboembolism in cancer patients

et al. 2020

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Oncological patients are a high-risk group for venous thromboembolic complications. These complications significantly impair the outcome of antitumor treatment and take a leading place in the structure of mortality. Treatment of venous thromboembolic complications in oncological patients is a serious challenge. When selecting an anticoagulant, the physician should consider its efficacy and safety and possible drug interactions. Based on results of multiple studies presented in this article, physicians will be able to choose an optimum therapeutic tactics and secondary prevention of thromboembolic complications for this group of patients.

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Treatment and secondary prevention of venous thromboembolism in cancer patients

et al. 2020

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The thrombodynamics test as a new opportunity for a polyclinic surgeon to monitor postoperative venous thromboembolic complications

Babitskiy,

Tkachenko,

Davydenko

et al. 2023

Ambulatornaya khirurgiya

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Introduction. Postoperative venous thromboembolic complications – a frequent and difficult to control problem for a polyclinic surgeon.Aim. To study and evaluate the possibilities of using the thrombodynamics test for the control of postoperative venous thromboembolic complications.Materials and methods. In 120 patients with common surgical pathology (chronic calculous cholecystitis, external abdominal hernias and varicose veins of the lower extremities), who underwent planned surgical treatment, stratified into risk groups of postoperative venous thromboembolic complications: low, moderate and high, in the postoperative period for 2–3, 7–9, 14–16, 30 days, a study of D-dimer, thrombodynamics test was conducted in parallel with ultrasound examination of the veins of the lower extremities. Results. It was revealed that hypercoagulation according to the thrombodynamics test was present in 34.2% of patients already at the first study, an increase in D-dimer was noted in 28.3% of patients at late follow-up, venous thrombosis was detected on ultrasound in 15% of the studied 6 people from each risk group within 2–15 days after surgery, carried in 83.3% The cases were asymptomatic, localized mainly in the deep veins of the lower leg and were always combined with hypercoagulation according to the thrombodynamics test and an increased level of D-dimer. It was noted that hypercoagulation against the background of the use of standard doses of anticoagulants in 61% of cases takes a positive trend, and in 39% remains unchanged.Discussion. Hypercoagulation recorded by the thrombodynamics test in the first days after surgery indicates insufficient effectiveness of standard thromboprophylaxis in the perioperative period. An increase in the D-dimer cannot be used as a prognosis of a prethrombotic state.Conclusions. Hypercoagulation as a precursor of venous thrombosis is well detected by the thrombodynamics test, its dynamics reflects the individual effectiveness of the use of anticoagulants, which justifies the possibility of using this indicator by a polyclinic surgeon in the control of postoperative venous thromboembolic complications.

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The possibilities of the thrombodynamics test in predicting, diagnosing and monitoring the effectiveness of the treatment of venous thromboembolic complications in planned surgical interventions

Babitsky,

Tkachenko,

Davydenko

et al. 2023

Regional blood circulation and microcirculation

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Introduction. The problem of venous thromboembolic complications after planned surgical interventions remains relevant and requires special research and analysis, which was the purpose of this work. Objective. To study and evaluate the possibilities of the thrombodynamics test for predicting, diagnosing, and monitoring the effectiveness of treatment of postoperative venous thromboembolic complications in planned surgical interventions. Materials and methods. In this study, we implemented the thrombodynamics test in parallel with ultrasound examination of the veins of the lower extremities and pelvis before planned surgery and in the postoperative period on 1–3, 7–9, 14–16, and 30 days in 120 patients with common surgical pathology (chronic calculous cholecystitis, external abdominal hernias, and varicose veins of the lower extremities) stratified into risk groups for postoperative venous thromboembolic complications. Results. It was revealed that, in the preoperative period, 16.6 % of patients have hypercoagulation at normal standard blood counts and 65 % of them are patients from a low-risk group of venous thromboembolic complications. In the postoperative period, the number of cases of hypercoagulation increased to 34.2 % due to elderly and senile patients from groups with an estimated moderate and high risk of venous thromboembolic complications. Deep vein thrombosis was detected in 18 (15 %) subjects (6 patients from each risk group) within 2–15 days after surgery and in all cases it developed in the presence of preoperative hypercoagulation. Conclusions. It is shown that the thrombodynamics test is highly informative in predicting, diagnosing and evaluating the effectiveness of venous thromboembolic complications treatment during planned surgical interventions.

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Toward the individual approach to the evaluation of risks and prevention of postoperative venous thromboembolism

Cited by 3 publications

References 102 publications

Treatment and secondary prevention of venous thromboembolism in cancer patients

Treatment and secondary prevention of venous thromboembolism in cancer patients

The thrombodynamics test as a new opportunity for a polyclinic surgeon to monitor postoperative venous thromboembolic complications

The possibilities of the thrombodynamics test in predicting, diagnosing and monitoring the effectiveness of the treatment of venous thromboembolic complications in planned surgical interventions

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