Towards 4D printing in pharmaceutics

Gazzaniga, A.; Foppoli, Anastasia; Cerea, Matteo; Palugan, Luca; Cirilli, Micol; Moutaharrik, Saliha; Melocchi, Alice; Maroni, Alessandra

doi:10.1016/j.ijpx.2023.100171

Cited by 13 publications

(9 citation statements)

References 59 publications

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“…[493][494][495][496] This approach helps a drug-loaded stimuliresponsive capsule release the medicine in a controlled manner under a specific stimulus at a specified body location. [497][498][499] Unlike traditional manufacturing methods, 3D printing is highly advantageous to develop personalized, made-on-demand, and unprecedented complex structures, which enhance the effectiveness, accessibility, and safety of drugs. [500][501][502][503][504] For instance, Melocchi et al [505] proposed an expandable system for gastric retention by assessing the shape-morphing behavior of pharmaceutical-grade polyvinyl alcohol (PVA).…”

Section: Biomedical Sectormentioning

confidence: 99%

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq,

Arif,

Khalid

et al. 2023

Adv Eng Mater

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Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, soft robots, wearable devices, sensors, self‐expanding structures, and biomedical devices, thanks to their ability to change their shapes and functional properties in response to external stimuli including light, humidity, heat, pH, electric field, solvent, and magnetic field or combinations of two or more of these stimuli. In recent years, additive manufacturing (AM) aka three‐dimensional (3D) printing technology of these SRPs, also known as four‐dimensional (4D) printing, has gained phenomenal attention in different engineering fields, thanks to its unique ability to develop complex, personalized, and innovative structures, which undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, and other complex morphological transformations. Herein, an effort has been made to provide insightful information about the AM techniques, type of SRPs, and their applications including, but not limited to tissue engineering, soft robots, bionics, actuators, sensors, construction, and smart textiles. This article also incorporates the current challenges and prospects, hoping to provide an insightful basis for the utilization of this technology in different engineering fields. It is expected that the amalgamation of 3D printing with SRPs would provide unparalleled advantages in different engineering arenas.This article is protected by copyright. All rights reserved.

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Section: Biomedical Sectormentioning

confidence: 99%

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq,

Arif,

Khalid

et al. 2023

Adv Eng Mater

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“…An important application of 4D bio-printing is related to pharmaceuticals, bio-adhesion, and drug delivery systems where drugs or cells are encapsulated and then released under the influence of a particular stimulus ( Trenfield et al, 2019 ). Efforts have been directed to develop responsive materials for being used in designing drug delivery systems for localized delivery of drugs and desired kinetics ( Gazzaniga et al, 2023 ). The transdermal drug delivery system has greatly accelerated with microneedles that can penetrate transdermal delivery systems in a painless and convenient manner ( Ma and Wu, 2017 ).…”

Section: 4dp Applicationsmentioning

confidence: 99%

4-Dimensional printing: exploring current and future capabilities in biomedical and healthcare systems—a Concise review

Agarwal,

Solanki,

Ameta

et al. 2023

Front. Bioeng. Biotechnol.

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4-Dimensional Printing (4DP) is the latest concept in the pharmacy and biomedical segment with enormous potential in dosage from personalization and medication designing, which adopts time as the fourth dimension, giving printed structures the flexibility to modify their morphology. It can be defined as the fabrication in morphology with the help of smart/intelligent materials like polymers that permit the final object to alter its properties, shape, or function in response to external stimuli such as heat, light, pH, and moisture. The applications of 4DP in biomedicines and healthcare are explored with a focus on tissue engineering, artificial organs, drug delivery, pharmaceutical and biomedical field, etc. In the medical treatments and pharmaceutical field 4DP is paving the way with unlimited potential applications; however, its mainstream use in healthcare and medical treatments is highly dependent on future developments and thorough research findings. Therefore, previous innovations with smart materials are likely to act as precursors of 4DP in many industries. This review highlights the most recent applications of 4DP technology and smart materials in biomedical and healthcare fields which can show a better perspective of 4DP applications in the future. However, in view of the existing limitations, major challenges of this technology must be addressed along with some suggestions for future research. We believe that the application of proper regulatory constraints with 4DP technology would pave the way for the next technological revolution in the biomedical and healthcare sectors.

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“…Thermoresponsive intelligent materials can reorganise and remodel in response to temperature stimuli [49]. For instance, a printed item may create a secondary state by submitting it to high temperatures under stress.…”

Section: Temperature Stimulusmentioning

confidence: 99%

A REVIEW ON 4D ADDITIVE MANUFACTURING - THE APPLICATIONS, SMART MATERIALS & EFFECT OF VARIOUS STIMULI ON 4D PRINTED OBJECTS

Maidin,

Jin Wee,

Sharum

et al. 2023

Jurnal Teknologi

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Additive Manufacturing, often known as 3D printing, is a process that uses a variety of materials to manufacture highly accurate items layer by layer. However, this technology has its limitations. One such limitation is the inability to print components larger than the printer's size due to the limited size of the build chamber. 4D additive manufacturing or 4D printing is an innovative development based on 3D printing that allows objects to be reshaped after printing, using stimuli-responsive materials that require external stimuli. This article present a review on 4D printing. Four databases, Google Scholar, ScienceDirect, IEEE Xplore, and Scopus database, were systematically searched for relevant review articles to identify and classify research studies. Specific keywords (4D printing, additive manufacturing, smart materials, stimuli, and application) were identified and used to guide the discovery of relevant studies. A total of 28 full articles were reviewed to study the applications of 4D printing, smart materials for 4D printing, as well as the effect of various stimuli on 4D printed objects. In conclusion, this review gives a summary of 4D printing and highlights its potential for revolutionizing manufacturing and further research is required to solve the limitations posed by this technology.

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Towards 4D printing in pharmaceutics

Cited by 13 publications

References 59 publications

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

4-Dimensional printing: exploring current and future capabilities in biomedical and healthcare systems—a Concise review

A REVIEW ON 4D ADDITIVE MANUFACTURING - THE APPLICATIONS, SMART MATERIALS & EFFECT OF VARIOUS STIMULI ON 4D PRINTED OBJECTS

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