Towards a biomanufacturing platform for cardenolides

Kreis, Wolfgang; Geiger, Daniel; Höhn, Stephanie; Meitinger, Nadine; Munkert, Jennifer; Petersen, Jan; Rieck, Christoph

doi:10.1055/s-0036-1596130

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Genetic Engineering and Molecular Biology1

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2017

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“…This requires biosynthetic genes that are introduced into microorganisms or appropriate genes that can be introduced in a given plant. Only limited studies have been published regarding cardenolides [78]. Transgenic D. lanata plants were obtained by Lehmann et al [6,79] using Agrobacterium tumefaciens-mediated transformation of protoplasts.…”

Section: Genetic Engineering and Molecular Biologymentioning

confidence: 99%

The Foxgloves (Digitalis) Revisited

Kreis

2017

Planta Med

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This review provides a renewed look at the genus Digitalis. Emphasis will be put on those issues that attracted the most attention or even went through paradigmatic changes since the turn of the millennium. PubMed and Google Scholar were used (“Digitalis” and “Foxglove” were the key words) to identify research from 2000 till 2017 containing data relevant enough to be presented here. Intriguing new results emerged from studies related to the phylogeny and taxonomy of the genus as well as to the biosynthesis and potential medicinal uses of the key active compounds, the cardiac glycosides. Several Eastern and Western Foxgloves were studied with respect to their propagation in vitro. In this context, molecular biology tools were applied and phytochemical analyses were conducted. Structure elucidation and analytical methods, which have experienced less exciting progress, will not be considered here in great detail.

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Section: Genetic Engineering and Molecular Biologymentioning

confidence: 99%

The Foxgloves (Digitalis) Revisited

Kreis

2017

Planta Med

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Towards a biomanufacturing platform for cardenolides

Cited by 1 publication

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The Foxgloves (Digitalis) Revisited

The Foxgloves (Digitalis) Revisited

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