Towards a pro-resolving concept in systemic lupus erythematosus

Boeltz, Sebastian; Hagen, Melanie; Knopf, Jasmin; Mahajan, Aparna; Schick, Maximilian; Zhao, Yi; Erfurt‐Berge, Cornelia; Rech, Jürgen; Muñoz, Luis E.; Herrmann, Martin

doi:10.1007/s00281-019-00760-5

Cited by 18 publications

(8 citation statements)

References 122 publications

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“…Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with severe organ damage involving both the innate and adaptive immune systems. Although the precious etiopathogenesis of SLE is not fully defined, growing evidence suggests that the clearance deficiency of apoptotic and necrotic cells and the degradation deficiency of NETosis (neutrophil extracellular traps) may play a vital role in SLE, especially in the early stages [ 1 , 2 ]. That is, the autoantigens contain nuclear substances released from the dead cells mentioned above, which are exposed to antigen-presenting cells (APCs), e.g., follicular dendritic cells and macrophages.…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Strategies for SLE by Targeting Anti-dsDNA Antibodies

Wang

Xiao

Xia

et al. 2021

Clinic Rev Allerg Immunol

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by diverse serological autoantibodies. Anti-dsDNA antibodies are involved in multiple organ damage, especially the kidney, skin, and central nervous system. Anti-dsDNA antibodies play a pivotal role in SLE, and researchers have developed therapeutic strategies targeting these antibodies. Approaches to reduce anti-dsDNA antibodies via B cell targeted biologics against B cell surface antigens, B cell survival factors, or Bruton’s tyrosine kinase have effectively eliminated B cells. However, their non-specific depletion hampers normal immune system functioning and limits the therapeutic benefits. Thus, scientists have attempted anti-dsDNA antibodies or lupus-specific strategies, such as the immature dendritic cell vaccine and immunoadsorption. Recently, synthetic mimic peptides (hCDR1, pCONs, DWEYS, FISLE-412, and ALW) that directly block anti-dsDNA autoantibodies have attracted attention, which could ameliorate lupus, decrease the serological autoantibody titer, reduce the deposition of renal autoantibodies, and improve pathological performance. These potent small peptide molecules are well tolerated, non-toxic, and non-immunogenic, which have demonstrated a benign safety profile and are expected to be hopeful candidates for SLE management. In this review, we clarify the role of anti-dsDNA antibodies in SLE, mainly focus on the current strategies targeting anti-dsDNA antibodies, and discuss their potential clinical value.

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Section: Introductionmentioning

confidence: 99%

The Therapeutic Strategies for SLE by Targeting Anti-dsDNA Antibodies

Wang

Xiao

Xia

et al. 2021

Clinic Rev Allerg Immunol

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“…Similarly, the inability to clear immune complexes (ICs) by defective M2-like macrophages results in organ damage by allowing ICs to accumulate in different tissues (48). Mechanically, apoptotic cells are eliminated by M2-like macrophages in a normally non-inflammatory response named efferocytosis (49). Such response gives rise to an increase of anti-inflammatory cytokines and a reduction of pro-inflammatory cytokines (50).…”

Section: M2-like Macrophages In Slementioning

confidence: 99%

Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus

Ahamada

Jia

2021

Front. Immunol.

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Systemic lupus erythematosus (SLE) is an autoimmune disease that attacks almost every organ. The condition mostly happens to adults but is also found in children, and the latter have the most severe manifestations. Among adults, females, especially non-Caucasian, are mostly affected. Even if the etiology of SLE remains unclear, studies show a close relation between this disease and both genetics and environment. Despite the large number of published articles about SLE, we still do not have a clear picture of its pathogenesis, and no specific drug has been found to treat this condition effectively. The implication of macrophages in SLE development is gaining ground, and studying it could answer these gaps. Indeed, both in vivo and in vitro studies increasingly report a strong link between this disease and macrophages. Hence, this review aims to explore the role of macrophages polarization and plasticity in SLE development. Understanding this role is of paramount importance because in-depth knowledge of the connection between macrophages and this systemic disease could clarify its pathogenesis and provide a foundation for macrophage-centered therapeutic approaches.

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“…Usually, inflammation is beneficial to the human body, which is the body's self-defence response. However, excessive or long-lasting inflammatory response can adversely affect the body and even cause some inflammatory-related diseases, such as rheumatoid arthritis (Schett, 2019), neuroinflammation (Dokalis and Prinz, 2019), lupus erythematosus (Boeltz et al, 2019), Crohn's disease (Schmitt et al, 2019), ulcerative colitis (Neurath and Leppkes, 2019) and uveitis (Wildner and Diedrichs-Mohring, 2019). Studies revealed that kaempferol not only exerts good anti-inflammatory effects in in vitro assays, but also in various animal model.…”

Section: Anti-inflammatory In Animalsmentioning

confidence: 99%

Advance toward isolation, extraction, metabolism and health benefits of kaempferol, a major dietary flavonoid with future perspectives

Li¹,

Gao

Bajpai

et al. 2021

Critical Reviews in Food Science and Nutrition

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As a major ubiquitous secondary metabolite, flavonoids are widely distributed in planta.Among flavonoids, kaempferol is a typical natural flavonol in diets and medicinal plants with myriad bioactivities, such as anti-inflammatory activity, anti-cancer activity, antioxidant activity, and anti-diabetic activity. However, the natural sources, absorption and metabolism as well as the bioactivities of kaempferol have not been reviewed comprehensively and systematically. This review highlights the latest research progress and the effect of kaempferol in the prevention and treatment of various chronic diseases, as well as its protective health effects, and provides a theoretical basis for future research to be used in nutraceuticals. Further, comparison of the different extraction and analytical methods are presented to highlight the most optimum for PG recovery and its detection in plasma and body fluids. Such review aims at improving the value-added applications of this unique dietary bioactive flavonoids at commercial scale and to provide a reference for its needed further development.

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Towards a pro-resolving concept in systemic lupus erythematosus

Cited by 18 publications

References 122 publications

The Therapeutic Strategies for SLE by Targeting Anti-dsDNA Antibodies

The Therapeutic Strategies for SLE by Targeting Anti-dsDNA Antibodies

Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus

Advance toward isolation, extraction, metabolism and health benefits of kaempferol, a major dietary flavonoid with future perspectives

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