Abstract:RIOK2 is an understudied kinase associated with a variety of human cancers including non-small
cell lung cancer and glioblastoma. No potent, selective, and cell-active chemical probe currently
exists for RIOK2. Such a reagent would expedite research into the biological functions of RIOK2
and validate it as a therapeutic target. Herein, we describe the synthesis of naphthyl-pyridine
based compounds that have both improved cellular activity while maintaining selectivity for
RIOK2.
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