Studies examining the joint interactions and impacts of social-environmental system (SES) drivers on vegetation dynamics in Central Asia are scarce. We investigated seasonal trends and anomalies in drivers and their impacts on ecosystem structure and function (ESF). We explored the response of net primary production (NPP), evapotranspiration (ET) and normalized difference vegetation index (NDVI) to various SES drivers − climate, human influence, heat stress, water storage, and water content − and their latent relationships in Kazakhstan. We employed 13 predictor drivers from 2000 to 2016 to identify the interactions and impacts on ESF variables that reflect vegetation growth and productivity. We developed 12 models with different predictor–response variable combinations and separated them into two approaches. First, we considered the winter percent snow cover (SNOWc) and spring rainfall (P_MAM) as drivers and then as moderators in a structural equation model. SNOWc variability (SNOWcSD) as an SEM moderator exhibited superior model accuracy and explained the interactions between various predictor–response combinations. Winter SNOWcSD did not have a strong direct positive influence on summer vegetation growth and productivity; however, it was an important moderator between human influence and the ESF variables. Spring rainfall had a stronger impact on ESF variability than summer rainfall. We also found strong positive feedback between soil moisture (SM) and NDVI, as well as a strong positive influence of vegetation optical depth (VOD) and terrestrial water storage (TWS) on ESF. Livestock density exhibited a strong negative influence on ESF. Our results also showed a strong positive influence of socioeconomic drivers, including crop yield per hectare (CROPh), gross domestic product per capita (GDPca), and population density (POPD) on vegetation productivity. Finally, we found that vegetation dynamics were more sensitive to SM, VOD, LSKD and POPD than climatic drivers, suggesting that water content and human influence drivers were more critical in Kazakhstan.