Towards a systematic scientific approach in the assessment of efficacy of an herbal preparation: Hawthorn (<i>Crataegus</i> spp.)

Furey, Ambrose; Tassell, Mary

doi:10.1016/j.ejheart.2008.10.003

Cited by 13 publications

(12 citation statements)

References 22 publications

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“…Crataegus monogyna and Crataegus laevigata are the major hawthorn species in middle Europe, Crataegus pentagyna , Crataegus nigra , and Crataegus azarolus in southern and southeastern Europe, and Crataegus pinnatifida and Crataegus scabrifolia in China [14, 15]. Available products include tinctures, tablets, teas, and aqueous extracts [16, 17]. Extracts may be prepared using hydroalcoholic (methanol or ethanol) or water-based extraction and are derived from various plant parts including, most commonly, berries or leaves and flowers [18].…”

Section: Chemical Constituentsmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

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Hawthorn (Crataegus oxyacantha) is a widely used Chinese herb for treatment of gastrointestinal ailments and heart problems and consumed as food. In North America, the role of treatment for heart problems dates back to 1800. Currently, evidence is accumulating from various in vivo and in vitro studies that hawthorn extracts exert a wide range of cardiovascular pharmacological properties, including antioxidant activity, positive inotropic effect, anti-inflammatory effect, anticardiac remodeling effect, antiplatelet aggregation effect, vasodilating effect, endothelial protective effect, reduction of smooth muscle cell migration and proliferation, protective effect against ischemia/reperfusion injury, antiarrhythmic effect, lipid-lowering effect and decrease of arterial blood pressure effect. On the other hand, reviews of placebo-controlled trials have reported both subjective and objective improvement in patients with mild forms of heart failure (NYHA I–III), hypertension, and hyperlipidemia. This paper discussed the underlying pharmacology mechanisms in potential cardioprotective effects and elucidated the clinical applications of Crataegus and its various extracts.

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Section: Chemical Constituentsmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

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“…The third study (8 weeks) recorded improvements in all parameters except blood pressure. [38] Furey and Tassell[39] however note that the findings of Asgary et al . demonstrated that hypotensive effects were specifically detected after 3 months of treatment.…”

Section: Clinical Trials and Related Researchmentioning

confidence: 99%

Hawthorn (Crataegus spp.) in the treatment of cardiovascular disease

Tassell¹,

Kingston²,

Gilroy³

et al. 2010

Phcog Rev

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103

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The medicinal properties of hawthorn (Crataegus spp., a genus comprising approximately 300 species) have been utilized by many cultures for a variety of therapeutic purposes for many centuries. In the Western world cardiovascular disease (CVD) has become one of the single most significant causes of premature death. Echoing this situation, more recent research into the therapeutic benefits of hawthorn preparations has focused primarily upon its cardiovascular effects. This review covers research into the various mechanisms of action proposed for Crataegus preparations, clinical trials involving Crataegus preparations, and the herb's safety profile.Clinical trials reviewed have been inconsistent in terms of criteria used (sample size, preparation, dosage, etc) but have been largely consistent with regard to positive outcomes. An investigation into data available to date regarding hawthorn preparations and herb/drug interactions reveals that theoretical adverse interactions have not been experienced in practice. Further, adverse reactions relating to the use of hawthorn preparations are infrequent and mild, even at higher dosage ranges. A recent retrospective study by Zick et al. has suggested a negative outcome for the long-term use of hawthorn in the prognosis of heart failure. These findings are examined in this paper.Although further research is needed in certain areas, current research to date suggests that hawthorn may potentially represent a safe, effective, nontoxic agent in the treatment of CVD and ischemic heart disease (IHD).

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“…It has been found that the separation of phenolic extracts of Crataegus into individual compounds does not appear to be beneficial regarding their anti-oxidant effects, as mixtures of compounds tend to exert stronger effects than those of individual compounds at the same concentrations. [12] Interestingly, when F3 was separated in the second fractionation, we found that F3´ presented the maximum relaxant effect ( Table 1). The HPLC-MS (Figure 4) results showed that this active fraction contained a highly complex mixture.…”

Section: Effect Of the Hexane Extract On The Histamine Or Kcl Pre-conmentioning

confidence: 90%

“…[12] In fact, many studies have been conducted to ascertain if hawthorn extracts can exert any therapeutic benefits in the treatment of cardiovascular disease or delay its onset. Frequently whole plant extracts and/or flavonoid combinations have been used as opposed to specific isolated classes of phytochemicals.…”

Section: Effect Of the Hexane Extract On The Histamine Or Kcl Pre-conmentioning

confidence: 99%

Relaxant Effect of the Extracts of Crataegus mexicana on Guinea Pig Tracheal Smooth Muscle

Arrieta¹,

Siles-Barrios²,

García-Sánchez³

et al. 2010

Pharmacognosy Journal

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a B S t r a c tCrataegus sp. has been used in the traditional medicine of Mexico as well as other countries for the treatment of several respiratory diseases, such as flu, cough and asthma. The tracheal relaxant effect of the leaves of C. mexicana is investigated here for the first time, through a bioassay-guided study by using isolated tracheal rings of guinea-pig as an experimental model. the hexane extract was the most active compared to dichloromethane and methanol. an active fraction was obtained from the hexane extract. Assays by HPLC-MS reveal that at least 14 compounds may exist in it. In addition, the results suggest that relaxant effect of the effective fraction was in part related to the activity of β-adrenergic receptors and not to K + atP channels. This study represents the first in which the relaxant effect of leaves of C. mexicana on tracheal rings of guinea pig was clearly demonstrated. More studies are required to correctly identify the bioactive compounds that contribute to the relaxant effects of Crataegus mexicana, and to know the mechanisms of action of these compounds.

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Towards a systematic scientific approach in the assessment of efficacy of an herbal preparation: Hawthorn (Crataegus spp.)

Cited by 13 publications

References 22 publications

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Hawthorn (Crataegus spp.) in the treatment of cardiovascular disease

Relaxant Effect of the Extracts of Crataegus mexicana on Guinea Pig Tracheal Smooth Muscle

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