With the rapid growth of 6G communication and smart sensor technology, the Internet of Things (IoT) has attracted much attention now. In the 6G-based IoT applications on the multiprocessor platform, the partitioned scheduling has been widely applied. However, these partitioned scheduling approaches could cause system resource waste and uneven workload among processors. In this paper, a smart semipartitioned scheduling strategy (SSPS) was proposed for mixed-criticality systems (MCS) in 6G-based edge computing. Besides tasks’ acceptance rate and weighted schedulability, QoS is considered in SSPS to improve the service quality of the system. The SSPS allocates tasks into each processor, and some tasks can migrate to other processors as soon as possible. By comparing with the several existing algorithms, the experimental results show that the SSPS achieves the best in the schedulability and QoS of the system.