Towards an optimal model for gastric cancer peritoneal metastasis: current challenges and future directions

Li, Z.; Wang, Jing‐Zhi; Wang, Zhenning; Xu, Yan

doi:10.1016/j.ebiom.2023.104601

Cited by 7 publications

(3 citation statements)

References 76 publications

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“…Convincing evidence indicates that lncRNAs play an important role in the pathogenesis of GC and have great value for GC diagnosis and treatment. 8 , 27 , 28 , 29 These abnormal lncRNAs are involved in various behaviors of GC cells, including proliferation, apoptosis, metastasis, drug resistance, etc. In this study, our main objective was to identify and validate an important lncRNA THUMPD3-AS1 and investigate its regulatory mechanisms for gastric cancer cell invasion and EMT in the context of gastric cancer by using clinical tissue samples and extensive biological analysis.…”

Section: Discussionmentioning

confidence: 99%

LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway

Zhang,

Li,

Fan

et al. 2023

iScience

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Section: Discussionmentioning

confidence: 99%

LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway

Zhang,

Li,

Fan

et al. 2023

iScience

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“…GC is a malignant tumor originating from the epithelium of the gastric mucosa, which can be detected in any part of the stomach, but commonly in the antrum, greater curvature, lesser curvature, and anterior and posterior wall of the stomach ( 1 , 2 ). The causative ingredients of GC are too varied to be fully identified.…”

Section: Introductionmentioning

confidence: 99%

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Qiu,

Lu,

et al. 2024

Front. Immunol.

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Gastric cancer (GC) is a malignant neoplasm originating from the epithelial cells of the gastric mucosa. The pathogenesis of GC is intricately linked to the tumor microenvironment within which the cancer cells reside. Tumor-associated macrophages (TAMs) primarily differentiate from peripheral blood monocytes and can be broadly categorized into M1 and M2 subtypes. M2-type TAMs have been shown to promote tumor growth, tissue remodeling, and angiogenesis. Furthermore, they can actively suppress acquired immunity, leading to a poorer prognosis and reduced tolerance to chemotherapy. Exosomes, which contain a myriad of biologically active molecules including lipids, proteins, mRNA, and noncoding RNAs, have emerged as key mediators of communication between tumor cells and TAMs. The exchange of these molecules via exosomes can markedly influence the tumor microenvironment and consequently impact tumor progression. Recent studies have elucidated a correlation between TAMs and various clinicopathological parameters of GC, such as tumor size, differentiation, infiltration depth, lymph node metastasis, and TNM staging, highlighting the pivotal role of TAMs in GC development and metastasis. In this review, we aim to comprehensively examine the bidirectional communication between GC cells and TAMs, the implications of alterations in the tumor microenvironment on immune escape, invasion, and metastasis in GC, targeted therapeutic approaches for GC, and the efficacy of potential GC drug resistance strategies.

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“…Although therapies such as surgical resection, radiotherapy and immunotherapy have made great advance in recent years, the overall survival (OS) rate of EC patients remains poor (7). Gastric cancer (GC) is a malignant tumor that originates in the stomach lining and is characterized by high morbidity and mortality rates (8,9). Factors like helicobacter pylori (Hp) infection, poor dietary habits, smoking, alcohol consumption, psychological factors, and genetics are closely linked to the advancement of GC (10).…”

Section: Introductionmentioning

confidence: 99%

Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via exosomes in gastrointestinal tumors

Cao,

Ouyang

2024

Front. Oncol.

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Gastrointestinal (GI) tumors are a significant global health threat, with high rates of morbidity and mortality. Exosomes contain various biologically active molecules like nucleic acids, proteins, and lipids and can serve as messengers for intercellular communication. They play critical roles in the exchange of information between tumor cells and the tumor microenvironment (TME). The TME consists of mesenchymal cells and components of the extracellular matrix (ECM), with fibroblasts being the most abundant cell type in the tumor mesenchyme. Cancer-associated fibroblasts (CAFs) are derived from normal fibroblasts and mesenchymal stem cells that are activated in the TME. CAFs can secrete exosomes to modulate cell proliferation, invasion, migration, drug resistance, and other biological processes in tumors. Additionally, tumor cells can manipulate the function and behavior of fibroblasts through direct cell-cell interactions. This review provides a summary of the intercellular crosstalk between GI tumor cells and CAFs through exosomes, along with potential underlying mechanisms.

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Towards an optimal model for gastric cancer peritoneal metastasis: current challenges and future directions

Cited by 7 publications

References 76 publications

LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway

LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via exosomes in gastrointestinal tumors

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