Towards Clinical Application of Mesenchymal Stromal Cells: Perspectives and Requirements for Orthopaedic Applications

Karagianni, Marianna; Schulze, Torsten J.

doi:10.5772/27901

Cited by 2 publications

(2 citation statements)

References 110 publications

(160 reference statements)

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“…To maintain tissue homeostasis in the body, stem and progenitors cells can be mobilized from their niches to the injury site for repairing [16]. Mesenchymal stem/stromal cells (MSCs) are target components for cell-based therapies, e.g., for bone and cartilage injuries, because of their multi-lineage differentiation potential and properties that promote regeneration [17]. Alternative to their application as ex vivo expanded cell products, induction of endogenous mobilization may provide a better outcome than current therapies.…”

Section: Introductionmentioning

confidence: 99%

Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results

et al. 2020

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OPEN ACCESS Citation: Gamez C, Schneider-Wald B, Schuette A, Mack M, Hauk L, Khan AuM, et al. (2020) Bioreactor for mobilization of mesenchymal stem/ stromal cells into scaffolds under mechanical stimulation: Preliminary results. PLoS ONE 15(1): e0227553. https://doi.org/10.1371/journal. ResultsThe bioreactor was able to stimulate the scaffolds and the cells for 24.4 (±1.7) hours, exerting compression with vertical displacements of 185.8 (±17.8) μm and a force-amplitude of 1.87 (±1.37; min 0.31, max 4.42) N. Our results suggest that continuous mechanical stimulation hampered the viability of the cells located at the cell reservoir when comparing to intermittent mechanical stimulation (34.4 ± 2.0% vs. 66.8 ± 5.9%, respectively).Functionalizing alginate scaffolds with laminin-521 (LN521) seemed to enhance the mobilization of cells from 48 (±21) to 194 (±39) cells/mm 3 after applying intermittent mechanical loading. ConclusionThe bioreactor presented here was able to provide mechanical stimulation that seemed to induce the mobilization of MSCs into LN521-alginate scaffolds under an intermittent loading regime.Bioreactor for mobilization of MSCs under mechanical stimulation PLOS ONE | https://doi.

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Section: Introductionmentioning

confidence: 99%

Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results

et al. 2020

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“…Co-transplantation with MSCs improves engraftment of HSCs after autologous intra-bone marrow transplantation [3]. MSCs are also considered useful as vehicles for emerging cell and gene therapies in the field of tissue engineering [4]. Recently it has been postulated that MSC provide the conducive microenvironment for HSCs and thus maintain the stemness and proliferation of HSCs and support HSC transplantation [3].…”

Section: Introductionmentioning

confidence: 99%

Pluripotent Stem Cells in Bone Marrow and Cord Blood

Shaikh¹,

Bhartiya²

2012

Blood Cell - An Overview of Studies in Hematology

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Towards Clinical Application of Mesenchymal Stromal Cells: Perspectives and Requirements for Orthopaedic Applications

Cited by 2 publications

References 110 publications

Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results

Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results

Pluripotent Stem Cells in Bone Marrow and Cord Blood

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