Towards highly efficient, intelligent and bimodal imaging probes: Novel approaches provided by lanthanide coordination chemistry

Bonnet, Célia S.; Tóth, Éva

doi:10.1016/j.crci.2010.03.026

Cited by 42 publications

(26 citation statements)

References 95 publications

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“…Bimodal imaging is presently gaining a great deal of interest since it can take advantage of great spatial, temporal resolution, and unlimited tissue penetration of MRI and high sensitivity of optical imaging. [25][26][27][28] Different classes of compounds have been designed as bimodal contrast agents, for example, Gd III chelates derivatized with luminescent dyes or transition-metal complexes, [29][30][31][32] as well as functionalized Fe 3 O 4 , [33] polymer, [34] or silica [35] nanoparticles.…”

Section: A C H T U N G T R E N N U N G (H 2 O) 3 ]mentioning

confidence: 99%

A Self‐Assembled Complex with a Titanium(IV) Catecholate Core as a Potential Bimodal Contrast Agent

Dehaen

Eliseeva

Kimpe

et al. 2011

Chemistry A European J

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A ditopic chelating ligand (H(6)4) that bears catechol and diethylenetriamine-N,N,N',N'',N''-pentaacetate (DTPA) has been designed and shown to specifically bind lanthanide(III) ions at the DTPA core ([Ln(H(2)4)(H(2)O)](-)) and further self-assemble with titanium(IV), thereby giving rise to the formation of a supramolecular metallostar complex with a lanthanide(III)-to-titanium(IV) ratio of 3:1, [(Ln4)(3)Ti(H(2)O)(3)](5-) (Ln=La, Eu, Gd). The efficacy of the metallostar complex as a potential bimodal optical/magnetic resonance imaging (MRI) agent has been evaluated. Nuclear magnetic relaxation dispersion (NMRD) measurements for the [(Gd4)(3)Ti(H(2)O)(3)](5-) complex have demonstrated an enhanced r(1) relaxivity that corresponds to 36.9 s(-1) mM(-1) per metallostar molecule at 20 MHz and 310 K, which is a result of a decreased tumbling rate. The ability of the complex to bind to human serum albumin (HSA) was also examined by relaxometric measurements. In addition, upon UV irradiation the [(Gd4)(3)Ti(H(2)O)(3)](5-) complex exhibits broad-band green emission in the range 400-750 nm with a maximum at 490 nm. Taking into account the high relaxivity and luminescence properties, the [(Gd4)(3)Ti(H(2)O)(3)](5-) complex is a good lead compound for the development of efficient bimodal contrast agents.

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Section: A C H T U N G T R E N N U N G (H 2 O) 3 ]mentioning

confidence: 99%

A Self‐Assembled Complex with a Titanium(IV) Catecholate Core as a Potential Bimodal Contrast Agent

Dehaen

Eliseeva

Kimpe

et al. 2011

Chemistry A European J

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“…10.1021/acs.langmuir.5b01516 Langmuir XXXX, XXX, XXX−XXX image reveals that the precipitates are network structures, suggesting the formation of coordination polymers between TPE-(EO)4-L2 and Gd 3+(Figure 1c). However, this network precipitates can be avoided if the same amount Gd 3+ solution is added into the TPE-(EO)4-L2/PMVP 41 -PEO 205 mixed solution.…”

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confidence: 91%

Electrostatic Polyion Micelles with Fluorescence and MRI Dual Functions

Huang

Yan

2015

Langmuir

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We report in this work the formation of fluorescence and MRI bimodal imaging nanoparticles achieved by electrostatic self-assembly. The nanoparticles are micelles formed with Gd(3+) ion, a bisligand that contains aggregation induced emission (AIE) group, and a block copolymer. The coordination between the Gd(3+) ion and the bisligand produces a negatively charged coordination complex, which interacted with the positive-neutral block copolymer to form polyion micelles. The micelles exhibit considerable fluorescence owing to the rotation restriction of the AIE group; meanwhile, the longitudinal relaxation of water was significantly slowed down which provide T1 contrast for magnetic resonance imaging. In vitro fluorescence imaging and in vivo MRI measurements verified this micelle indeed exhibit dual imaging ability. We expect that this orthogonal imaging may provide more accurate diagnosis in practical applications and will pave the way for the development of an advanced technique for diagnosis.

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“…[3] Dual MR /optical imaging is advantageous because it combines the high spatial resolution of MRI at the anatomical level with the high sensitivity of optical detection at the cellular level. [3,4] The ligand in such dual agents should fulfill several requirements: form thermodynamically stable and kinetically inert complexes with Ln 3+ to prevent toxicity associated with free lanthanide ions, provide a mechanism for the efficient paramagnetic relaxation enhancement of the bulk water protons and sensitize characteristic emission of a luminescent lanthanide ion (antenna effect). This last point is particularly important since most of f-f- transitions of Ln 3+ are Laporte-forbidden and exhibit very low molar absorption coefficients making their direct excitation difficult.…”

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confidence: 99%

“…This last point is particularly important since most of f-f- transitions of Ln 3+ are Laporte-forbidden and exhibit very low molar absorption coefficients making their direct excitation difficult. [2,3] However, this problem can be overcome if the organic ligand includes an appropriate chromophoric moiety that can absorb excitation energy and transfer it to the corresponding Ln 3+ . [2,3] Efficient relaxation of bulk water protons by Gd 3+ requires at least one rapidly exchanging inner sphere water molecule, [1] but this requirement appears to be incompatible with the design of optical agents, especially those emitting in the NIR range, because the overtones of O-H vibrations can quench the Ln 3+ excited states through non-radiative deactivation.…”

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confidence: 99%

“…[2,3] However, this problem can be overcome if the organic ligand includes an appropriate chromophoric moiety that can absorb excitation energy and transfer it to the corresponding Ln 3+ . [2,3] Efficient relaxation of bulk water protons by Gd 3+ requires at least one rapidly exchanging inner sphere water molecule, [1] but this requirement appears to be incompatible with the design of optical agents, especially those emitting in the NIR range, because the overtones of O-H vibrations can quench the Ln 3+ excited states through non-radiative deactivation. [5] It has been shown, however, that in some Ln 3+ -based complexes, the NIR emission can be efficiently sensitized despite the presence of several coordinated water molecules.…”

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confidence: 99%

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Lanthanide DO3A‐Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium

et al. 2017

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In this work, we describe a novel DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) based ligand with a chromophoric tropone coordinating sidearm (1). Ln3+ complexes of 1 have one inner sphere water molecule. The r1 relaxivity of Gd1 is similar to that of the commercial Gd-based MRI agents. The neutral O-donor atom of the tropone moiety slows down the water exchange rate by a factor of 3 compared to GdDOTA. In addition, Nd1 and Yb1 complexes exhibit significant NIR emission in aqueous solutions indicating that the tropone unit is an efficient sensitizer for these Ln3+-ions. Therefore, this new ligand is a promising platform for the design of Ln3+ based dual MR/optical imaging probes.

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Towards highly efficient, intelligent and bimodal imaging probes: Novel approaches provided by lanthanide coordination chemistry

Cited by 42 publications

References 95 publications

A Self‐Assembled Complex with a Titanium(IV) Catecholate Core as a Potential Bimodal Contrast Agent

A Self‐Assembled Complex with a Titanium(IV) Catecholate Core as a Potential Bimodal Contrast Agent

Electrostatic Polyion Micelles with Fluorescence and MRI Dual Functions

Lanthanide DO3A‐Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium

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