Towards Modeling Anhedonia and Its Treatment in Zebrafish

Abreu, Murilo S. de; Costa, Fabiano V.; Giacomini, Ana C.V.V.; Demin, Konstantin A.; Zabegalov, Konstantin N.; Maslov, Gleb O.; Kositsyn, Yuriy M; Petersen, Elena; Strekalova, Tatiana; Kalueff, Allan V.

doi:10.1093/ijnp/pyab092

Cited by 8 publications

(3 citation statements)

References 206 publications

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“…Studies on zebrafish have identified modifications in neural circuits within these brain regions following exposure to stress or trauma [41]. Neurotransmitter systems have also been examined, with dysregulation of serotonin 5-hydroxytryptophan (5-HT) linked to anxietylike behavior in zebrafish subjected to stress paradigms [42]. Moreover, investigations into the HPA axis have revealed insights into dysregulation after stress exposure, leading to altered cortisol levels and stress-related behaviors [43,44].…”

Section: Neuroanatomical and Neurochemical Insights From Zebrafish Pt...mentioning

confidence: 99%

Zebrafish Model in Illuminating the Complexities of Post-Traumatic Stress Disorders: A Unique Research Tool

Al-Zoubi,

Abu-Hijleh,

Zarour

et al. 2024

IJMS

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Post-traumatic stress disorder (PTSD) is a debilitating psychological condition that may develop in certain individuals following exposure to life-threatening or traumatic events. Distressing symptoms, including flashbacks, are characterized by disrupted stress responses, fear, anxiety, avoidance tendencies, and disturbances in sleep patterns. The enduring effects of PTSD can profoundly impact personal and familial relationships, as well as social, medical, and financial stability. The prevalence of PTSD varies among different populations and is influenced by the nature of the traumatic event. Recently, zebrafish have emerged as a valuable model organism in studying various conditions and disorders. Zebrafish display robust behavioral patterns that can be effectively quantified using advanced video-tracking tools. Due to their relatively simple nervous system compared to humans, zebrafish are particularly well suited for behavioral investigations. These unique characteristics make zebrafish an appealing model for exploring the underlying molecular and genetic mechanisms that govern behavior, thus offering a powerful comparative platform for gaining deeper insights into PTSD. This review article aims to provide updates on the pathophysiology of PTSD and the genetic responses associated with psychological stress. Additionally, it highlights the significance of zebrafish behavior as a valuable tool for comprehending PTSD better. By leveraging zebrafish as a model organism, researchers can potentially uncover novel therapeutic interventions for the treatment of PTSD and contribute to a more comprehensive understanding of this complex condition.

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Section: Neuroanatomical and Neurochemical Insights From Zebrafish Pt...mentioning

confidence: 99%

Zebrafish Model in Illuminating the Complexities of Post-Traumatic Stress Disorders: A Unique Research Tool

Al-Zoubi,

Abu-Hijleh,

Zarour

et al. 2024

IJMS

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“…In rats, chronic stress was found to decrease reward-seeking behaviours, exploration, and locomotor activity in rodents, and these reductions are regarded as loss of motivation. Anhedonia has been extensively studied in zebrafish with a recent review highlighting the behavioural tests used to study the various phenotypes of anhedonia ( de Abreu et al, 2022 ). Amongst them, the conditioned place preference (CPP) test could be implemented to mimic the effects of the sucrose preference test in rodents.…”

Section: Behavioural Tests In Fish Modelsmentioning

confidence: 99%

Teleosts as behaviour test models for social stress

Lai,

Mohd Zahir,

Liew

et al. 2023

Front. Behav. Neurosci.

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Stress is an important aspect of our everyday life and exposure to it is an unavoidable occurrence. In humans, this can come in the form of social stress or physical stress from an injury. Studies in animal models have helped researchers to understand the body’s adaptive response to stress in human. Notably, the use of behavioural tests in animal models plays a pivotal role in understanding the neural, endocrine and behavioural changes induced by social stress. Under socially stressed conditions, behavioural parameters are often measured physiological and molecular parameters as changes in behaviour are direct responses to stress and are easily assessed by behavioural tests. Throughout the past few decades, the rodent model has been used as a well-established animal model for stress and behavioural changes. Recently, more attention has been drawn towards using fish as an animal model. Common fish models such as zebrafish, medaka, and African cichlids have the advantage of a higher rate of reproduction, easier handling techniques, sociability and most importantly, share evolutionary conserved genetic make-up, neural circuitry, neuropeptide molecular structure and function with mammalian species. In fact, some fish species exhibit a clear diurnal or seasonal rhythmicity in their stress response, similar to humans, as opposed to rodents. Various social stress models have been established in fish including but not limited to chronic social defeat stress, social stress avoidance, and social stress-related decision-making. The huge variety of behavioural patterns in teleost also aids in the study of more behavioural phenotypes than the mammalian species. In this review, we focus on the use of fish models as alternative models to study the effects of stress on different types of behaviours. Finally, fish behavioural tests against the typical mammalian model-based behavioural test are compared and discussed for their viability.

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“…The animal model zebrafish has been gained ground in several fields of research and as a model for complex brain disorders [23]. It has also been used to evaluate the pathological mechanisms of affective disorders [24]. This can be achieved through the zebrafish's response to different stimuli, which allows researchers to study biological and pharmaceutical processes [25].…”

Section: Introductionmentioning

confidence: 99%

Toxicological Response of Zebrafish Exposed to Cocktails of Polymeric Materials and Valproic Acid

Savuca,

Chelaru,

Balmus

et al. 2024

Sustainability

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Microplastic pollution represents an emerging problem of great interest in the public domain in the last decade; in addition, it overlaps with another delicate problem—pollution with pharmaceutical products that can have negative effects on the environment and people, even in small amounts. The main purpose of this study was to assess the biochemical and behavioral effects of exposure of adult zebrafish (Danio rerio) to polyethylene (PE), polypropylene (PP) and valproic acid (VPA), respectively to their mixtures—possible situations in natural aquatic environments. In terms of behavioral responses, sociability appears to be more impaired in the PP group after 5 days of exposure. The mechanisms affected are more those of swimming performance than of sociability. Even more, VPA increases presence in the arm with conspecifics but decreases mobility and locomotion, indicating a possible anxiety mechanism. The mixtures decrease the aggressiveness, especially in the case of the PE+VPA group, where it reaches a super low level compared to the control, which could endanger the species in nature. Regarding the anxiogenic effect, PP and PE act differently: if PE has an anxiogenic effect, on the opposite side is the PP group, which shows a bolder and more agitated behavior. All four variants showed behavioral changes indicative of toxicity from the first dose.

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Towards Modeling Anhedonia and Its Treatment in Zebrafish

Cited by 8 publications

References 206 publications

Zebrafish Model in Illuminating the Complexities of Post-Traumatic Stress Disorders: A Unique Research Tool

Zebrafish Model in Illuminating the Complexities of Post-Traumatic Stress Disorders: A Unique Research Tool

Teleosts as behaviour test models for social stress

Toxicological Response of Zebrafish Exposed to Cocktails of Polymeric Materials and Valproic Acid

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