Towards nano-diagnostics for rapid diagnosis of infectious diseases – current technological state

Salieb-Beugelaar, Georgette B.; Hunziker, Patrick

doi:10.1515/ejnm-2014-0004

Cited by 8 publications

(5 citation statements)

References 70 publications

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“…Recent publications show progress in miniaturization of diagnostic technologies, paving the way to multiparameter testing by integration of multiple assays into a single device or test substrate [for further reading see (51,52)]. …”

Section: Towards Multiparameter Testingmentioning

confidence: 99%

Improving diagnosis of pneumococcal disease by multiparameter testing and micro/nanotechnologies

Salieb-Beugelaar¹,

Zhang

Nigo³

et al. 2016

European Journal of Nanomedicine

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The diagnosis and management of pneumococcal disease remains challenging, in particular in children who often are asymptomatic carriers, and in low-income countries with a high morbidity and mortality from febrile illnesses where the broad range of bacterial, viral and parasitic cases are in contrast to limited, diagnostic resources. Integration of multiple markers into a single, rapid test is desirable in such situations. Likewise, the development of multiparameter tests for relevant arrays of pathogens is important to avoid overtreatment of febrile syndromes with antibiotics. Miniaturization of tests through use of micro-and nanotechnologies combines several advantages: miniaturization reduces sample requirements, reduces the use of consumables and reagents leading to a reduction in costs, facilitates parallelization, enables point-of-care use of diagnostic equipment and even reduces the amount of potentially infectious disposables, characteristics that are highly desirable in most healthcare settings. This critical review emphasizes our vision on the importance of multiparametric testing for diagnosing pneumococcal infections in patients with fever and examines recent relevant developments in micro/nanotechnologies to achieve this goal.

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Section: Towards Multiparameter Testingmentioning

confidence: 99%

Improving diagnosis of pneumococcal disease by multiparameter testing and micro/nanotechnologies

Salieb-Beugelaar¹,

Zhang

Nigo³

et al. 2016

European Journal of Nanomedicine

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“…They integrate, in a single chip, several functional modules for specimen processing, biochemical reactions, transportation, and product detection, with on-chip control of thermo-pneumatic pumps, micro-heaters, temperature sensors, miniaturized fluorescence detectors, sample/analyte concentrators, and filters. 109,110,111 Microfluidic techniques are increasingly incorporated into diagnostic systems due to the inherent advantages of miniaturization and integration of complex functionality. This development could move sophisticated diagnostic tools out of the developed-world laboratory and create portable POC medical diagnostics, especially in low resource setting.…”

Section: Microfluidic Platformsmentioning

confidence: 99%

Diagnosing dengue virus infection: rapid tests and the role of micro/nanotechnologies

Zhang

Salieb-Beugelaar

Nigo

et al. 2015

Nanomedicine: Nanotechnology, Biology and Medicine

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“…Microfluidic systems are of growing importance for applications in the field of, for example, nanomedicine, biomedicine, rapid diagnostics and single cell investigations [ 1 , 2 , 3 , 4 ]. The production of microdevices developed rapidly over the last decade and commonly used methods are standard photolithography, micromachining and polymer molding.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic 3D Helix Mixers

et al. 2016

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Polymeric microfluidic systems are well suited for miniaturized devices with complex functionality, and rapid prototyping methods for 3D microfluidic structures are increasingly used. Mixing at the microscale and performing chemical reactions at the microscale are important applications of such systems and we therefore explored feasibility, mixing characteristics and the ability to control a chemical reaction in helical 3D channels produced by the emerging thread template method. Mixing at the microscale is challenging because channel size reduction for improving solute diffusion comes at the price of a reduced Reynolds number that induces a strictly laminar flow regime and abolishes turbulence that would be desired for improved mixing. Microfluidic 3D helix mixers were rapidly prototyped in polydimethylsiloxane (PDMS) using low-surface energy polymeric threads, twisted to form 2-channel and 3-channel helices. Structure and flow characteristics were assessed experimentally by microscopy, hydraulic measurements and chromogenic reaction, and were modeled by computational fluid dynamics. We found that helical 3D microfluidic systems produced by thread templating allow rapid prototyping, can be used for mixing and for controlled chemical reaction with two or three reaction partners at the microscale. Compared to the conventional T-shaped microfluidic system used as a control device, enhanced mixing and faster chemical reaction was found to occur due to the combination of diffusive mixing in small channels and flow folding due to the 3D helix shape. Thus, microfluidic 3D helix mixers can be rapidly prototyped using the thread template method and are an attractive and competitive method for fluid mixing and chemical reactions at the microscale.

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Towards nano-diagnostics for rapid diagnosis of infectious diseases – current technological state

Cited by 8 publications

References 70 publications

Improving diagnosis of pneumococcal disease by multiparameter testing and micro/nanotechnologies

Improving diagnosis of pneumococcal disease by multiparameter testing and micro/nanotechnologies

Diagnosing dengue virus infection: rapid tests and the role of micro/nanotechnologies

Microfluidic 3D Helix Mixers

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