Towards new multivalent supramolecular helical structures based on phthalocyanines for PDT applications

Abstract

The self-assembly of [Formula: see text]-D-glucose octafunctionalized Zn(II) phtalocyanine (ZnPc) in aqueous media has been investigated using different techniques such as UV, CD and diffusion-ordered [Formula: see text]H-NMR spectroscopy (DOSY). The formation of supramolecular columnar helical aggregates with a preferred handedness due to the presence of the sugar moiety has been confirmed by these techniques. Moreover, the stability of the supramolecular polymers formed has been assessed by using pyridine as a zinc ligand, disrupting the aggregates or inducing their formation by dilution of the system.

Phthalocyanines Structure Versus Photodynamic Effectiveness towards Pathogenic Microorganisms: Our Recent Experience

“…However, the knowledge about these drugs suggested the low uptake capacity and non-selective efficiency on pathogenic bacteria and fungi [18]. On the other hand, taking into account the structural flexibility and the advanced optical properties of MPcs, such as the long wavelength of absorption (> 680 nm), the high molar absorptivity (> 10 5 M -1 •cm -1 ), lack of dark toxicity and relatively high photocytotoxicity, the promising MPcs with advanced properties towards pathogenic species are under development [19,20].…”