Towards practical and sustainable SERS: a review of recent developments in the construction of multifunctional enhancing substrates

Li, Chunchun; Huang, Yiming; Li, Xinyuan; Zhang, Yingrui; Chen, Qinglu; Ye, Ziwei; Alqarni, Zarah; Bell, Steven E. J.; Xu, Yikai

doi:10.1039/d1tc02134f

Cited by 136 publications

(82 citation statements)

References 291 publications

(253 reference statements)

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“…Re‐usable SERS substrates are a specific category of multi‐functional substrates known as regeneration‐enhancement‐in‐one substrates. However, there are several other categories of multi‐functional substrates, including flexible substrates, separation‐enhancement‐in‐one substrates, calibration‐enhancement‐in‐one substrates and regeneration‐enhancement‐in‐one substrates 261 . Flexible substrates have been covered previously in the section of ‘SERS nanosubstrates’ in this review, so here we will focus on the other three categories.…”

Section: Discussionmentioning

confidence: 99%

“…For more details on each of these categories, as well as detailed information on regeneration mechanisms, please see the in‐depth review by Li et al. from 2021 261 . There are a plethora of ways for reusable substrates to be multi‐functional outside of their reusability, but one area of particular interest is reusable substrates with contaminant removal abilities.…”

Section: Discussionmentioning

confidence: 99%

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Applications of surface‐enhanced Raman spectroscopy in environmental detection

Terry

Sanders

Potoff

et al. 2022

Analytical Science Advances

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As the human population grows, the anthropogenic impacts from various agricultural and industrial processes produce unwanted contaminants in the environment. The accurate, sensitive and rapid detection of such contaminants is vital for human health and safety. Surface-enhanced Raman spectroscopy (SERS) is a valuable analytical tool with wide applications in environmental contaminant monitoring. The aim of this review is to summarize recent advancements within SERS research as it applies to environmental detection, with a focus on research published or accessible from January 2021 through December 2021 including early-access publications. Our goal is to provide a wide breadth of information that can be used to provide background knowledge of the field, as well as inform and encourage further development of SERS techniques in protecting environmental quality and safety. Specifically, we highlight the characteristics of effective SERS nanosubstrates, and explore methods for the SERS detection of inorganic, organic, and biological contaminants including heavy metals, pharmaceuticals, plastic particles, synthetic dyes, pesticides, viruses, bacteria and mycotoxins. We also discuss the current limitations of SERS technologies in environmental detection and propose several avenues for future investigation. We encourage researchers to fill in the identified gaps so that SERS can be implemented in a real-world environment more effectively and efficiently, ultimately providing reliable and timely data to help and make science-based strategies and policies to protect environmental safety and public health.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Applications of surface‐enhanced Raman spectroscopy in environmental detection

Terry

Sanders

Potoff

et al. 2022

Analytical Science Advances

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show abstract

“…In this case, the detection of targets relies on the enhanced signals of Raman reporters on NPs. A variety of SERS NPs coated with different targeting ligands have been developed, benefiting SERS-based multiplexing analysis [ 75 , 76 ]. SERS NPs possesses great potentials in bioimaging, immunoassay, microtumor diagnosis, as well as intraoperative navigation [ 64 , [77] , [78] , [79] , [80] ].…”

Section: Main Metabolic Molecules Detecting Methodsmentioning

confidence: 99%

Human metabolite detection by surface-enhanced Raman spectroscopy

Liu

2022

Materials Today Bio

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Metabolites are important biomarkers in human body fluids, conveying direct information of cellular activities and physical conditions. Metabolite detection has long been a research hotspot in the field of biology and medicine. Surface-enhanced Raman spectroscopy (SERS), based on the molecular “fingerprint” of Raman spectrum and the enormous signal enhancement (down to a single-molecule level) by plasmonic nanomaterials, has proven to be a novel and powerful tool for metabolite detection. SERS provides favorable properties such as ultra-sensitive, label-free, rapid, specific, and non-destructive detection processes. In this review, we summarized the progress in recent 10 years on SERS-based sensing of endogenous metabolites at the cellular level, in tissues, and in biofluids, as well as drug metabolites in biofluids. We made detailed discussions on the challenges and optimization methods of SERS technique in metabolite detection. The combination of SERS with modern biomedical technology were also anticipated.

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“…In recent years, surface enhanced Raman scattering (SERS) spectroscopy has grown dramatically with the development of nanosensors with engineered surface properties. SERS is a phenomenon associated with the amplification of the Raman signals of analytes located near the surface of nanostructured metallic substrates [15]. The growing availability of reliable commercial SERS substrates, coupled with relatively cheap portable Raman spectrometers, is helping SERS to emerge as a new innovative solution for the measurement of drugs in body fluids (especially in plasma, serum, and urine) [16][17][18][19], offering a high specific, sensitive, and low-cost technology that can be potentially brought to the patient's bedside and easily operated by doctors or health personnel.…”

Section: Introductionmentioning

confidence: 99%

The Role of Surface Enhanced Raman Scattering for Therapeutic Drug Monitoring of Antimicrobial Agents

2022

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The rapid quantification of antimicrobial agents is important for therapeutic drug monitoring (TDM), enabling personalized dosing schemes in critically ill patients. Highly sophisticated TDM technology is becoming available, but its implementation in hospitals is still limited. Among the various proposed techniques, surface-enhanced Raman scattering (SERS) stands out as one of the more interesting due to its extremely high sensitivity, rapidity, and fingerprinting capabilities. Here, we present a comprehensive review of various SERS-based novel approaches applied for direct and indirect detection and quantification of antibiotic, antifungal, and antituberculosis drugs in different matrices, particularly focusing on the challenges for successful exploitation of this technique in the development of assays for point-of-care tests.

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Towards practical and sustainable SERS: a review of recent developments in the construction of multifunctional enhancing substrates

Abstract: Surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique, which allows quantitative detection of chemical species with molecular specificity and single-molecule sensitivity. These useful properties can be further combined with...

Cited by 136 publications

References 291 publications

Applications of surface‐enhanced Raman spectroscopy in environmental detection

Applications of surface‐enhanced Raman spectroscopy in environmental detection

Human metabolite detection by surface-enhanced Raman spectroscopy

The Role of Surface Enhanced Raman Scattering for Therapeutic Drug Monitoring of Antimicrobial Agents

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