2024
DOI: 10.1002/cmtd.202400049
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Towards Precision Biocatalysis – Leveraging Inline NMR for Autonomous Experimentation in Flow Reactors

Felix Ott,
Gudrun Gygli,
Kersten S. Rabe
et al.

Abstract: Reactor automation is a transformative force for chemical processes, but the potential of reaction monitoring for machine‐assisted autonomous biocatalytic reaction optimization is still largely unexplored. To address this gap, we report on automated reactor optimization for biocatalytic flow‐through microreactors. For this purpose, the inline NMR analysis of an enzymatically catalyzed stereoselective reduction of a prochiral diketone was combined with a self‐developed open‐source analysis and control software.… Show more

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