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As eries of gold(I) pioneer complexes bearing N-heterocyclic carbenes and steroid derivatives (ethynylestradiol and ethisterone) with the generic formula [Au(R 2 -imidazol-2-ylidene)(steroid)] (whereR = CH 3 or CH 2 CH 2 OCH 3 )w ere synthesized, and the X-ray structure of ar are of gold(I)-estradiol derivativei s discussed. The first report on antibacterial and antifungal properties of metal-NHC complexes dates from 1996, [2] and sincet hen, their use has become widespread. To xicityp rofiling was estimated in vitro versus Gram-positive (Staphylococcus aureus)a nd Gram-negative (Escherichia coli)b acteria, and in vivo on Galleria mellonella larvae against E. coli.
The search and design of novel compounds exhibitinga ntibacterial or antimicrobiala ctivityh as evolved in line with the progress of chemistry,a nd today there is aw ide variety of examples.
As eries of gold(I) pioneer complexes bearing N-heterocyclic carbenes and steroid derivatives (ethynylestradiol and ethisterone) with the generic formula [Au(R 2 -imidazol-2-ylidene)(steroid)] (whereR = CH 3 or CH 2 CH 2 OCH 3 )w ere synthesized, and the X-ray structure of ar are of gold(I)-estradiol derivativei s discussed. The first report on antibacterial and antifungal properties of metal-NHC complexes dates from 1996, [2] and sincet hen, their use has become widespread. To xicityp rofiling was estimated in vitro versus Gram-positive (Staphylococcus aureus)a nd Gram-negative (Escherichia coli)b acteria, and in vivo on Galleria mellonella larvae against E. coli.
The search and design of novel compounds exhibitinga ntibacterial or antimicrobiala ctivityh as evolved in line with the progress of chemistry,a nd today there is aw ide variety of examples.