Toxic effect of different ZnO particles on mouse alveolar macrophages

Jinyang, Zhang; Song, Wei; Guo, Jing; Zhang, Jinhua; Sun, Zengtian; Ding, Feng; Gao, Minling

doi:10.1016/j.jhazmat.2012.03.069

Cited by 44 publications

(25 citation statements)

References 33 publications

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“…Nano-materials are theoretically expected to be more potent than their bulk equivalents because of their greater surface reactivity and the ability to penetrate into cells and organisms [19,20]. It has been previously shown that some potent effects of nano-zinc particles were related to their PH-triggered release of Zn 2+ ions in the culture medium or inside cells or in the aquatic mediums [21][22][23][24][25]. Nano-zinc ions induce metallothionein synthesis.…”

Section: Introductionmentioning

confidence: 99%

Effects of Nano-zinc on Biochemical Parameters in Cadmium-Exposed Rats

Hejazy

Koohi

2017

Biol Trace Elem Res

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Cadmium (Cd) is a toxic environmental and occupational pollutant with reported toxic effects on the kidneys, liver, lungs, bones, and the immunity system. Based on its physicochemical similarity to cadmium, zinc (Zn) shows protective effects against cadmium toxicity and cadmium accumulation in the body. Nano-zinc and nano-zinc oxide (ZnO), recently used in foods and pharmaceutical products, can release a great amount of Zn in their environment. This research was carried out to investigate the more potent properties of the metal zinc among sub-acute cadmium intoxicated rats. Seventy-five male Wistar rats were caged in 15 groups. Cadmium chloride (CdCl) was used in drinking water to induce cadmium toxicity. Different sizes (15, 20, and 30 nm) and doses of nano-zinc particles (3, 10, 100 mg/kg body weight [bw]) were administered solely and simultaneously with CdCl (2-5 mg/kg bw) for 28 days. The experimental animals were decapitated, and the biochemical biomarkers (enzymatic and non-enzymatic) were determined in their serum after oral exposure to nano-zinc and cadmium. Statistical analysis was carried out with a one-way ANOVA and t test. P < 0.05 was considered as statistically significant. The haematocrit (HCT) significantly increased and blood coagulation time significantly reduced in the nano-zinc-treated rats. AST, ALT, triglyceride, total cholesterol, LDL, and free fatty acids increased significantly in the cadmium- and nano-zinc-treated rats compared with the controls. However, albumin, total protein, and HDLc significantly decreased in the cadmium- and nano-zinc-treated rats compared with the controls (P < 0.05). It seems that in the oral administration of nano-zinc, the smaller sizes with low doses and the larger sizes with high doses are more toxic than metallic zinc. In a few cases, an inverse dose-dependent relationship was seen as well. This research showed that in spite of larger sizes of zinc, smaller sizes of nano-zinc particles are not suitable for protection against cadmium intoxication.

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Section: Introductionmentioning

confidence: 99%

Effects of Nano-zinc on Biochemical Parameters in Cadmium-Exposed Rats

Hejazy

Koohi

2017

Biol Trace Elem Res

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“…Thus, myeloid cells have been used in several studies dealing with zinc oxide toxicity 6,11,21,26,27 . Most of these studies have concentrated on the classical chronic inflammation scheme, and investigated the production of pro-inflammatory cytokines upon treatment with zinc oxide.…”

Section: Introductionmentioning

confidence: 99%

Analysis of cellular responses of macrophages to zinc ions and zinc oxide nanoparticles: a combined targeted and proteomic approach

et al. 2014

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Two different zinc oxide nanoparticles, as well as zinc ion, are used to study the cellular responses of the RAW264 macrophage cell line. A proteomic screen is used to provide a wide view of the molecular effects of zinc, and the most prominent results are crossvalidated by targeted studies. Furthermore, the alteration of important macrophage functions (e.g. phagocytosis) by zinc is also investigated. The intracellular dissolution/uptake of zinc is also studied to further characterize zinc toxicity. Zinc oxide nanoparticles dissolve readily in the cells, leading to high intracellular zinc concentrations, mostly as protein-bound zinc. The proteomic screen reveals a rather weak response in the oxidative stress response pathway, but a strong response both in the central metabolism and in the proteasomal protein degradation pathway. Targeted experiments confirm that carbohydrate catabolism and proteasome are critical determinants of sensitivity to zinc, which also induces DNA damage. Conversely, glutathione levels and phagocytosis appear unaffected at moderately toxic zinc concentrations.3

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“…50 Despite that, there is an argument as to whether the toxicity toward these cells was attributed solely to released ionic Zn 2+ , or the non-dissolved particle of ZnO, or the combination of these two processes. 51,52 This will induce oxidative stress, DNA damage and eventually cell death via apoptosis. for HeLa, HepG2, HT29 and 3T3, respectively.…”

mentioning

confidence: 99%

Anticancer nanodelivery system with controlled release property based on protocatechuate–zinc layered hydroxide nanohybrid

Barahuie

Hussein

Gani

et al. 2014

IJN

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Background We characterize a novel nanocomposite that acts as an efficient anticancer agent. Methods This nanocomposite consists of zinc layered hydroxide intercalated with protocatechuate (an anionic form of protocatechuic acid), that has been synthesized using a direct method with zinc oxide and protocatechuic acid as precursors. Results The resulting protocatechuic acid nanocomposite (PAN) showed a basal spacing of 12.7 Å, indicating that protocatechuate was intercalated in a monolayer arrangement, with an angle of 54° from the Z-axis between the interlayers of the zinc layered hydroxide, and an estimated drug loading of about 35.7%. PAN exhibited the properties of a mesoporous type material, with greatly enhanced thermal stability of protocatechuate as compared to its free counterpart. The presence of protocatechuate in the interlayers of the zinc layered hydroxide was further supported by Fourier transform infrared spectroscopy. Protocatechuate was released from PAN in a slow and sustained manner. This mechanism of release was well represented by a pseudo-second order kinetics model. PAN has shown increased cytotoxicity compared to the free form of protocatechuic acid in all cancer cell lines tested. Tumor growth suppression was extensive, particularly in HepG2 and HT29 cell lines. Conclusion PAN is suitable for use as a controlled release formulation, and our in vitro evidence indicates that PAN is an effective anticancer agent. PAN may have potential as a chemotherapeutic drug for human cancer.

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Toxic effect of different ZnO particles on mouse alveolar macrophages

Cited by 44 publications

References 33 publications

Effects of Nano-zinc on Biochemical Parameters in Cadmium-Exposed Rats

Effects of Nano-zinc on Biochemical Parameters in Cadmium-Exposed Rats

Analysis of cellular responses of macrophages to zinc ions and zinc oxide nanoparticles: a combined targeted and proteomic approach

Anticancer nanodelivery system with controlled release property based on protocatechuate–zinc layered hydroxide nanohybrid

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Toxic effect of different ZnO particles on mouse alveolar macrophages

Cited by 44 publications

References 33 publications

Effects of Nano-zinc on Biochemical Parameters in Cadmium-Exposed Rats

Effects of Nano-zinc on Biochemical Parameters in Cadmium-Exposed Rats

Analysis of cellular responses of macrophages to zinc ions and zinc oxide nanoparticles: a combined targeted and proteomic approach

Anticancer nanodelivery system with controlled release property based on protocatechuate&ndash;zinc layered hydroxide nanohybrid

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Product

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Anticancer nanodelivery system with controlled release property based on protocatechuate–zinc layered hydroxide nanohybrid