Toxic Effects from Ivermectin Use Associated with Prevention and Treatment of Covid-19

Temple, Courtney; Hoang, Ruby; Hendrickson, Robert G.

doi:10.1056/nejmc2114907

Cited by 68 publications

(56 citation statements)

References 4 publications

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“…1 Our citations regarding off-label ivermectin use only included the New England Journal of Medicine, the Center for Disease Control Health Advisory Network, the National Institutes of Health, and the Food and Drug Administration. [3][4][5] These acknowledgments aside, Bryant's letter serves as an opportunity to highlight important and potentially controversial considerations when performing meta-analyses. 1 As we demonstrate, decisions regarding these issues can dramatically influence the results of systematic reviews and metaanalyses.…”

Section: Meta-analyses Do Not Establish Improved Mortality With Iverm...mentioning

confidence: 99%

Meta-Analyses Do Not Establish Improved Mortality With Ivermectin Use in COVID-19

Rothrock

Weber

Giordano

et al. 2022

American Journal of Therapeutics

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A day after our investigative reporter Mary Beth pfeiffer proved that the FDA lied (and thousands likely died) with the ivermectin horse-dewormer hoax, she was locked out of twitter; 2021. Available at: https://rescue. substack.com/p/a-day-after-our-investigative-reporter. Accessed October 18, 2021. 32. Mississippi State Dept of Health. Increased poison control calls due to ivermectin ingestion and potential toxicity; 2021. MS Health Alert Network Alert. Available at: https://msdh.ms.gov/msdhsite/_static/resources/15400. pdf. August 20, 2021. 33. Pfeiffer MB, Bonvie L. Horse-bleep: how 4 calls on animal ivermectin launched a false FDA-media attack on a lifesaving human medicine; 2021. Available at: https://rescue. substack.com/p/a2520b80-bcd1-4905-a913-68f6f6809779. 34. U.S. FDA. You are not a horse, 2021. "Tweet", 21 August 2021. 35. Mole B. Ivermectin overdose death probed in NM: "I don't want more people to die", 2021.

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Section: Meta-analyses Do Not Establish Improved Mortality With Iverm...mentioning

confidence: 99%

Meta-Analyses Do Not Establish Improved Mortality With Ivermectin Use in COVID-19

Rothrock

Weber

Giordano

et al. 2022

American Journal of Therapeutics

View full text Add to dashboard Cite

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“…Ivermectin is approved in some countries for the treatment of parasitic infections, but not for COVID-19. In particular, the World Health Organization does not recommend the use of this drug except in the context of a clinical trial [ 101 ] and other studies advise against its use [ 102 - 104 ].…”

Section: Known Drugs With Other Indications Under Evaluation For Covi...mentioning

confidence: 99%

Pharmacological treatment of COVID-19: an opinion paper

García‐Lledó¹,

Gómez-Pavón²,

Castillo³

et al. 2021

Rev Esp Quimioter

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The precocity and efficacy of the vaccines developed so far against COVID-19 has been the most significant and saving advance against the pandemic. The development of vaccines has not prevented, during the whole period of the pandemic, the constant search for therapeutic medicines, both among existing drugs with different indications and in the development of new drugs. The Scientific Committee of the COVID-19 of the Illustrious College of Physicians of Madrid wanted to offer an early, simplified and critical approach to these new drugs, to new developments in immunotherapy and to what has been learned from the immune response modulators already known and which have proven effective against the virus, in order to help understand the current situation.

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“…In any case, it should be clearly stated that, like any other medication, judicious use of ivermectin could be considered for selected COVID-19 patients, since inappropriate or excessive prescription of this agent may potentially lead to undesirable effects, including drug interactions [73,74]. In this respect, it should be acknowledged that rare cases of ivermectin toxicity have been recently reported [75]. The latter might be attributed to homozygosity for a nonsense mutation in gene ABCB1 [76].…”

Section: Covid-19 Evidence-based Treatmentsmentioning

confidence: 99%

Ofeleein i mi Vlaptin—Volume II: Immunity Following Infection or mRNA Vaccination, Drug Therapies and Non-Pharmacological Management at Post-Two Years SARS-CoV-2 Pandemic

et al. 2022

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The persistence of the coronavirus disease 2019 (COVID-19) pandemic has triggered research into limiting transmission, morbidity and mortality, thus warranting a comprehensive approach to guide balanced healthcare policies with respect to people’s physical and mental health. The mainstay priority during COVID-19 is to achieve widespread immunity, which could be established through natural contact or vaccination. Deep knowledge of the immune response combined with recent specific data indicates the potential inferiority of induced immunity against infection. Moreover, the prevention of transmission has been founded on general non-pharmacological measures of protection, albeit debate exists considering their efficacy and, among other issues, their socio-psychological burden. The second line of defense is engaged after infection and is supported by a plethora of studied agents, such as antibiotics, steroids and non-steroid anti-inflammatory drugs, antiviral medications and other biological agents that have been proposed, though variability in terms of benefits and adverse events has not allowed distinct solutions, albeit certain treatments might have a role in prevention and/or treatment of the disease. This narrative review summarizes the existing literature on the advantages and weaknesses of current COVID-19 management measures, thus underlining the necessity of acting based on the classical principle of “ofeleein i mi vlaptin”, that is, to help or not to harm.

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Toxic Effects from Ivermectin Use Associated with Prevention and Treatment of Covid-19

Cited by 68 publications

References 4 publications

Meta-Analyses Do Not Establish Improved Mortality With Ivermectin Use in COVID-19

Meta-Analyses Do Not Establish Improved Mortality With Ivermectin Use in COVID-19

Pharmacological treatment of COVID-19: an opinion paper

Ofeleein i mi Vlaptin—Volume II: Immunity Following Infection or mRNA Vaccination, Drug Therapies and Non-Pharmacological Management at Post-Two Years SARS-CoV-2 Pandemic

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