Toxic effects of lead exposure on bioaccumulation, oxidative stress, neurotoxicity, and immune responses in fish: A review

Lee, Ju-Wook; Choi, Hoon; Hwang, Un-Ki; Kang, Ju‐Chan; Kang, Yue Jai; Kim, Kwang Il; Kim, Jun-Hwan

doi:10.1016/j.etap.2019.03.010

Cited by 352 publications

(123 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Table 1 represents the various sources of lead contamination in agricultural soils, crops, and water in different countries/regions of the world. It is evidenced in Table 1 that the anthropogenic products and processes (such as industrial, oil-processing activities, agrochemicals, paint, smelting, mining, refining, informal recycling of lead, cosmetics, peeling window and door frames, jewelry, toys, ceramics, pottery, plumbing materials and alloys, water from old pipes, vinyl mini-blinds, stained glass, lead-glazed dishes, firearms with lead bullets, batteries, radiators for cars and trucks, and some colors of ink) are considered to be major sources of Pb contamination in the environment [14][15][16][17][18][19][20][21].…”

Section: Sources Of Pb Contamination In Soil Crops and Water Resourcesmentioning

confidence: 99%

Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches

Kumar

Pinto

Chaturvedi

et al. 2020

IJERPH

627

229

View full text Add to dashboard Cite

Lead (Pb) toxicity has been a subject of interest for environmental scientists due to its toxic effect on plants, animals, and humans. An increase in several Pb related industrial activities and use of Pb containing products such as agrochemicals, oil and paint, mining, etc. can lead to Pb contamination in the environment and thereby, can enter the food chain. Being one of the most toxic heavy metals, Pb ingestion via the food chain has proven to be a potential health hazard for plants and humans. The current review aims to summarize the research updates on Pb toxicity and its effects on plants, soil, and human health. Relevant literature from the past 20 years encompassing comprehensive details on Pb toxicity has been considered with key issues such as i) Pb bioavailability in soil, ii) Pb biomagnification, and iii) Pb- remediation, which has been addressed in detail through physical, chemical, and biological lenses. In the review, among different Pb-remediation approaches, we have highlighted certain advanced approaches such as microbial assisted phytoremediation which could possibly minimize the Pb load from the resources in a sustainable manner and would be a viable option to ensure a safe food production system.

show abstract

Section: Sources Of Pb Contamination In Soil Crops and Water Resourcesmentioning

confidence: 99%

Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches

Kumar

Pinto

Chaturvedi

et al. 2020

IJERPH

627

229

View full text Add to dashboard Cite

show abstract

“…In fact, it affects almost all tissues and organ systems, such as the respiratory, hematopoietic, renal, cardiovascular, urinary, and urogenital systems, as well as bones [2][3][4][5]. Moreover, apart from its widely characterized effects in humans [4][5][6][7][8] and animals [3], the detrimental effects of Pb on the physiology of plants [9] and fish [10][11][12] have also been well-documented.…”

Section: Introductionmentioning

confidence: 99%

(Ascorb)ing Pb Neurotoxicity in the Developing Brain

Ahmad

Liu

2020

Antioxidants

View full text Add to dashboard Cite

Lead (Pb) neurotoxicity is a major concern, particularly in children. Developmental exposure to Pb can alter neurodevelopmental trajectory and has permanent neuropathological consequences, including an increased vulnerability to further stressors. Ascorbic acid is among most researched antioxidant nutrients and has a special role in maintaining redox homeostasis in physiological and physio-pathological brain states. Furthermore, because of its capacity to chelate metal ions, ascorbic acid may particularly serve as a potent therapeutic agent in Pb poisoning. The present review first discusses the major consequences of Pb exposure in children and then proceeds to present evidence from human and animal studies for ascorbic acid as an efficient ameliorative supplemental nutrient in Pb poisoning, with a particular focus on developmental Pb neurotoxicity. In doing so, it is hoped that there is a revitalization for further research on understanding the brain functions of this essential, safe, and readily available vitamin in physiological states, as well to justify and establish it as an effective neuroprotective and modulatory factor in the pathologies of the nervous system, including developmental neuropathologies.

show abstract

“…It is mainly found in trace amounts in soil, plants and water, and commonly used in batteries, automobiles, paint, ceramics, plastics, etc. Therefore, it is human activity that causes high dose exposure to lead, and lead enters the food chain of animals or humans by infiltration into groundwater systems (Beyer et al, 2013;Lee et al, 2019;Mason, Harp, & Han, 2014). Long-term consumption of lead-containing foods or water results in lead accumulation in the body (Metryka et al, 2018), which causes nervous and regenerative system disorders, stunting, anemia, and hypertension (Flora, Gupta, & Tiwari, 2012;Lee et al, 2019;Mason et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it is human activity that causes high dose exposure to lead, and lead enters the food chain of animals or humans by infiltration into groundwater systems (Beyer et al, 2013;Lee et al, 2019;Mason, Harp, & Han, 2014). Long-term consumption of lead-containing foods or water results in lead accumulation in the body (Metryka et al, 2018), which causes nervous and regenerative system disorders, stunting, anemia, and hypertension (Flora, Gupta, & Tiwari, 2012;Lee et al, 2019;Mason et al, 2014). Several countries have reported on the hazards of lead exposure (Aksu, Balkis, Taskin, & Ersan, 2011;Caravanos et al ;Sampson & Winter, 2016;Yakub & Iqbal, 2010), and have set maximum permissible limits.…”

Section: Introductionmentioning

confidence: 99%

Development of a fluorescent quantification strip assay for the detection of lead

Kuang

et al. 2020

Food and Agricultural Immunology

View full text Add to dashboard Cite

Lead (Pb) is a toxic metal that can accumulate in the body and negatively impact human health. In this study, we prepared a highly sensitive and specific monoclonal antibody, 2C3, that can recognize Pb(II) with an IC50 and linear range of 0.5 ng/mL and 0.08-1.86 ng/mL, respectively. Additionally, based on this antibody we developed a fluorescent test strip, which can be used for both qualitative and quantitative detection of Pb(II) in brown rice with a detection range of 4.67-47.8 ng/mL. Therefore, the method we developed has high sensitivity suitable for the detection of Pb(II) in brown rice.

show abstract

Toxic effects of lead exposure on bioaccumulation, oxidative stress, neurotoxicity, and immune responses in fish: A review

Cited by 352 publications

References 82 publications

Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches

Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches

(Ascorb)ing Pb Neurotoxicity in the Developing Brain

Development of a fluorescent quantification strip assay for the detection of lead

Contact Info

Product

Resources

About