Toxic effects of Streptomyces griseus spores and exudate on gill pathology of freshwater fish

Lewis, J. W.; Morley, N.J.; Drinkall, Janice; Jamieson, Barbara; Wright, Rosalind M.; Parry, Jacqueline D.

doi:10.1016/j.ecoenv.2008.07.011

Cited by 11 publications

(4 citation statements)

References 18 publications

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“…We observed diffuse lamellar fusion and inflammatory infiltrate throughout the gill filament and lamellae in severe cases. Lamellar fusion is a common response in gills to a number of pathogens and irritants, likely to reduce the surface area exposed to pathogens or toxins (Mallatt 1985;Lewis et al 2009), although it is often difficult to determine the cause of these changes in an uncontrolled environment. In this study, much of the affected gill tissue contained developmental stages of P. minibicornis, and the severity of the gill pathology was correlated with P. minibicornis levels in the kidney and gills.…”

Section: Discussionmentioning

confidence: 99%

Parvicapsula minibicornis infections in gill and kidney and the premature mortality of adult sockeye salmon (Oncorhynchus nerka) from Cultus Lake, British Columbia

Bradford

Lovy

Patterson

et al. 2010

Can. J. Fish. Aquat. Sci.

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In recent years, large losses of migrating adult sockeye salmon ( Oncorhynchus nerka ) from the Fraser River, British Columbia, Canada, have resulted in reductions in catches and productivity. We investigated patterns of mortality and the occurrence of the myxosporean parasite Parvicapsula minibicornis in adult sockeye salmon from Cultus Lake, tributary to the Fraser River. Using data from a captive broodstock program, we found that early migrants to Cultus Lake had less severe P. minibicornis infections and were more likely to survive to maturity than those fish that arrived later after they had presumably held in the warmer Fraser River. We found P. minibicornis in kidneys and gills of spawners. In some fish, significant histopathology in the gills that included severe inflammation and hyperplasia of the gill lamellae was observed; the severity of the disease was correlated with the severity of P. minibicornis infections. Kidney and gill pathologies were more prevalent and more severe in fish that died before spawning compared with those that matured successfully. Gill disease associated with P. minibicornis infections had not been previously identified in Fraser River sockeye salmon, and its role in the loss of spawners needs further investigation.

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Section: Discussionmentioning

confidence: 99%

Parvicapsula minibicornis infections in gill and kidney and the premature mortality of adult sockeye salmon (Oncorhynchus nerka) from Cultus Lake, British Columbia

Bradford

Lovy

Patterson

et al. 2010

Can. J. Fish. Aquat. Sci.

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show abstract

“…This is particularly clear in the case of thaxtomins and potato scab, which was discussed earlier. It has also been reported that the symptoms of a disease of fish lungs induced by a strain of S. griseus can be reproduced by extracts from agar culture medium, although it is not known whether this effect is attributable to a secondary metabolite (Lewis et al , 2008).…”

Section: The Diverse Roles Of Secondary Metabolitesmentioning

confidence: 99%

The complex extracellular biology ofStreptomyces

et al. 2010

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Streptomycetes, soil-dwelling mycelial bacteria that form sporulating aerial branches, have an exceptionally large number of predicted secreted proteins, including many exported via the twin-arginine transport system. Their use of noncatalytic substrate-binding proteins and hydrolytic enzymes to obtain soluble nutrients from carbohydrates such as chitin and cellulose enables them to interact with other organisms. Some of their numerous secreted proteases participate in developmentally significant extracellular cascades, regulated by inhibitors, which lead to cannibalization of the substrate mycelium biomass to support aerial growth and sporulation. They excrete many secondary metabolites, including important antibiotics. Some of these play roles in interactions with eukaryotes. Surprisingly, some antibiotic biosynthetic enzymes are extracellular. Antibiotic production is often regulated by extracellular signalling molecules, some of which also control morphological differentiation. Amphipathic proteins, assembled with the help of cellulose-like material, are required for both hyphal attachment to surfaces and aerial reproductive growth. Comparative genomic analysis suggests that the acquisition of genes for extracellular processes has played a huge part in speciation. The rare codon TTA, which is present in the key pleiotropic regulatory gene adpA and many pathway-specific regulatory genes for antibiotic production, has a particular influence on extracellular biology.

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“…In conjunction with the Environment Agency UK, University of Lancaster and University of Warwick, techniques such as SEM, high-pressure liquid chromatography, mass spectrometry and molecular approaches, have shown that microbial toxins, especially from strains of actinobacteria (e.g. Streptomyces griseus) are responsible for massive fish mortalities in many aquatic habitats throughout the UK (Lewis et al, 2009(Lewis et al, , 2012.…”

Section: Aquatic Toxicologymentioning

confidence: 99%

An appreciation of Professor John Lewis

Rollinson

2017

J. Helminthol.

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Toxic effects of Streptomyces griseus spores and exudate on gill pathology of freshwater fish

Cited by 11 publications

References 18 publications

Parvicapsula minibicornis infections in gill and kidney and the premature mortality of adult sockeye salmon (Oncorhynchus nerka) from Cultus Lake, British Columbia

Parvicapsula minibicornis infections in gill and kidney and the premature mortality of adult sockeye salmon (Oncorhynchus nerka) from Cultus Lake, British Columbia

The complex extracellular biology ofStreptomyces

An appreciation of Professor John Lewis

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