Toxic Epidermal Necrolysis

Rasmussen, James E.

doi:10.1016/s0025-7125(16)31573-5

Cited by 69 publications

(8 citation statements)

References 74 publications

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“…7,8 Roujeau's6 and our studies show that only a small number of patients (4.5% and 3%, respectively) with TEN had not taken any drugs. The French survey confirms our observation of the larger number of female patients involved (61.2% in the French study; 64.3% in our study) and also a mortal¬ ity rate of about one third (30% in the French study; 34% in our study).…”

Section: Resultsmentioning

confidence: 45%

Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome

Schöpf

Stühmer²,

Rzany³

et al. 1991

Arch Dermatol

310

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Little work has been carried out on the epidemiology of the two serious skin reactions--toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS). We collected details of all the hospitalized cases of TEN and SJS in the Federal Republic of Germany for the years 1981 through 1985 inclusive. Inquiries by telephone, letter, and personal visits produced an overall response of 91%; 259 cases of TEN and 315 cases of SJS were identified. From these data, we were able to calculate an overall annual risk of 0.93 and 1.1 per million for TEN and SJS, respectively. The average age group was higher for TEN (63 years) than for SJS (25 years). Women are markedly more at risk for TEN in the ratio of 2:1, these figures being reversed for SJS. The mortality was 34% (87/259) for TEN and only 1% (2/315) for SJS. An association with previous medication defined as "definite, probable, possible" could be established for 89% of cases of TEN and 54% of cases of SJS. The drugs most commonly involved were antibiotics (TEN, 40%; SJS, 34%), followed by the analgesics (TEN, 23%; SJS, 33%). As with the drug groups, the incidences being based on the defined daily doses, were high for sulfonamides, beta-lactam antibiotics, and some nonsteroidal anti-inflammatory drugs.

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Section: Resultsmentioning

confidence: 45%

Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome

Schöpf

Stühmer²,

Rzany³

et al. 1991

Arch Dermatol

310

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“…Lyell 10 believed that corticosteroids made little difference in the course of TEN. Rasmussen 11 reported a series of children with SJS in which steroids appeared to do more harm than good. Infections and gastrointestinal bleeding were much more common in the steroid‐treated group.…”

Section: Discussionmentioning

confidence: 99%

Erythema multiforme, Stevens–Johnson syndrome and toxic epidermal necrolysis in northeastern Malaysia

Kamaliah

Zainal²,

Mokhtar³

et al. 1998

Int J Dermatology

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“…It is associated with infections, drugs, and vaccination as well as with systemic disease and malignancies [ 1-31. Its dramatic symptomatology contrasts, in most cases, with the previously good health of the patients [4]. The cutaneous pathology is, in general, symmetrical and includes mucosal involvement.…”

Section: Introductionmentioning

confidence: 90%