Toxic epidermal necrolysis

Schwartz, Robert A.; McDonough, Patrick Henry; Lee, Brian W.

doi:10.1016/j.jaad.2013.05.002

Cited by 277 publications

(92 citation statements)

References 125 publications

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“…Skin biopsy is also diagnostic revealing an intraepidermal cleavage, with splitting of stratum granulosum, which may contain acantholytic cells. The epidermis appears unremarkable and dermis without inflammatory cells 1, 3. S. aureus toxin‐mediated infection are evident in children.…”

Section: Discussionmentioning

confidence: 99%

Severe case of staphylococcal scalded skin syndrome in a 5‐year‐old child – case report

Aydin

Alsbjørn

2016

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Severe case of staphylococcal scalded skin syndrome in a 5‐year‐old child – case report

Aydin

Alsbjørn

2016

Clinical Case Reports

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“…The blood level and urine level of paraquat were not tested in both patients. Following the accepted criteria [1], the diagnosis of TEN was established.…”

Section: Discussionmentioning

confidence: 99%

“…Toxic epidermal necrolysis (TEN) consists of rare but life-threatening severe cutaneous adverse reactions, which are in the majority induced by a variety of drugs such as allopurinol, antibacterial sulfonamides, some anticonvulsants (phenytoin, phenobarbital, carbamazepine and lamotrigine), anti-HIV drugs (nevirapine) and nonsteroidal anti-inflammatory drugs (oxicam) [1,2]. In addition, other causative agents like mycoplasma pneumonia, dengue virus, cytomegalovirus and contrast medium could also induce this disease [2].…”

Section: Introductionmentioning

confidence: 99%

Paraquat Poisoning Followed by Toxic Epidermal Necrolysis: A Report of Two Cases and Published Work Review

Xu¹,

Li-ya²,

Wang³

et al. 2015

Dermatology

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Toxic epidermal necrolysis (TEN) is a life-threatening, typically drug-induced, mucocutaneous disease. Whether paraquat, one of the most widely used herbicides, could induce TEN is not known. We describe 2 paraquat-poisoned patients with TEN. Both patients presented erythema after hospital discharge following initial paraquat poisoning and then developed a widespread eruption of diffuse erythema on almost the whole body, with bullae, epidermal necrosis and sloughing. They were successfully treated with intravenous immunoglobulin and methylprednisolone. These clinical features were consistent with TEN caused by medications with a high risk to induce Stevens-Johnson syndrome/TEN. Moreover, it is suggested that both skin exposure and ingestion of paraquat could induce TEN. To our knowledge, this is the first case report of TEN related to paraquat poisoning.

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“…The mortality rate can be predicted by using the severity-of-illness score named SCORTEN [ 52 ]. As patients are on high risk for sepsis, it is essential to transfer them to an intensive care burn unit [ 53 ]. Prevention of infection is essential as well as maintenance of fl uid and electrolyte balance and nutritional support.…”

Section: Toxic Epidermal Necrolysismentioning

confidence: 99%