1981
DOI: 10.1016/0041-0101(81)90016-7
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Toxic material from the gallbladder of the grass carp (Ctenopharyngodon idellus)

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Cited by 25 publications
(12 citation statements)
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“…In 1 patient, acute renal failure developed in spite of first boiling the bile. This coincides with the observation that boiled carp bile is still toxic in animals, even though the toxicity is lessened [6].…”
Section: Clinical Coursementioning
confidence: 64%
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“…In 1 patient, acute renal failure developed in spite of first boiling the bile. This coincides with the observation that boiled carp bile is still toxic in animals, even though the toxicity is lessened [6].…”
Section: Clinical Coursementioning
confidence: 64%
“…But the existence of such a toxin is supported by the fact that boiled bile is toxic in animals [5] and in man, as shown in our cases. Bile salts, the major components of bile, are thought to be its toxic constituents [15], since they make up about 90% of the dry weight of the bile salt fraction [8], Some laboratories tried to extract the toxic substance from grass carp bile [6,8] but failed. Recently, it was shown that acute renal failure developed after oral inges tion of carp bile in rats, while it did not develop after raw hog bile [8], So the nephrotoxicity of fish bile is specific for the carp family, but mammalian bile is relatively nonnephrotoxic.…”
Section: Clinical Coursementioning
confidence: 99%
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“…The role and involvement of NO in signal transduction within the PTs have been studied extensively. NO also regulates HCO 3 -and Na + transport by a cyclic GMP mediated mechanism in the PTs [12], inhibits Na + /K + -ATPase in mouse PTs [13], and controls glomerular hemodynamics and PT reabsorption [14].…”
Section: Introductionmentioning
confidence: 99%
“…Mild poisoning causes only gastroenteritis, liver and kidneys are affected in moderate poisoning, and multiorgan failure occurs in severe poisoning. The toxin involved in fish gall bladder poisoning is believed to be 5-alpha cyprinol sulphate, a C-27 bile acid [8,9]. Poisoning (ichthyotoxism) occurs in 3 forms [10], e.g., (a) ichthyosarcotoxic involving visceral organ, (b) ichthyootoxic involving reproductive organs and (c) ichthyohemotoxic causing hemolysis like feature.…”
Section: Discussionmentioning
confidence: 98%