Toxicity ameliorative effect of vitamin E against super-paramagnetic iron oxide nanoparticles on haemato-immunological responses, antioxidant capacity, oxidative stress, and metabolic enzymes activity during exposure and recovery in Labeo rohita fingerlings

Kumar, Munish; Gupta, Gyandeep; Muhammed, N.; Karthik, R; Varghese, Tincy; Srivastava, Prem Prakash; Bhushan, Shashi; Shukla, Satya Prakash; Krishna, Gopal; Subodh, Gupta

doi:10.1007/s10499-022-00870-2

Cited by 9 publications

(4 citation statements)

References 124 publications

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“…The high activity of the three digestive enzymes in the heat treatment groups suggested that the M. nipponense activated a higher digestion level to provide more energy to defend against acute heat stress. (Kumar et al 2022). In this study, T-SOD activities only in the 35 ℃ groups were signi cantly higher than in the control group (Fig.…”

Section: Discussionmentioning

confidence: 45%

Transcriptomic, histological and biochemical analyses of Macrobrachium nipponense response to acute heat stress

Fan

Knepper

et al. 2022

Preprint

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Temperature is an essential factor affecting the viability of crustaceans, and high temperature can cause damage or even death. The oriental river prawn, Macrobrachium nipponense, is an important economic aquaculture species in China, Japan, and Vietnam. To identify the transcriptomic, histological, and biochemical response of M. nipponense and reveal their adaptation mechanisms, the prawns were placed at 25 ℃, 30 ℃, and 35 ℃ for 24 h. The histological damages in the gills and hepatopancreas of M. nipponense were found under acute heat stress. Additionally, acute heat stress enhanced the digestive, metabolic, and antioxidative capacity of M. nipponense by biochemical analysis. The total RNA of hepatopancreas and gills were isolated and sequenced using the RNA-Seq method. After filtration, assembly, and aggregation, a total of 131690 unigenes were identified. Gene ontology (GO) analysis revealed that differentially expressed genes (DEGs) were significantly involved in the regulation of transcription by RNA polymerase II, proteolysis, nucleus, cytoplasm, nucleus, and ATP binding. In the hepatopancreas, several pathways were significantly enriched in the treatment groups, including neuroactive ligand-receptor interaction, thyroid hormone synthesis, and ECM-receptor interaction. And in the gills, cGMP-PKG signaling pathway, ribosome, and calcium signaling pathway, were enriched. The transcriptomic analysis provided insights into the thermoregulation and molecular mechanisms of M. nipponense in response to acute heat stress.

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Section: Discussionmentioning

confidence: 45%

Transcriptomic, histological and biochemical analyses of Macrobrachium nipponense response to acute heat stress

Fan

Knepper

et al. 2022

Preprint

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“…Te cellular antioxidant level is used to determine the susceptibility of tissues to oxidative damage. Tis level normally changes during oxidative stress [17][18][19]. A wide variety of antioxidants are naturally obtained from plants that constitute our daily diet.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and In Vitro Evaluation of the Antioxidant Potential of Dichloromethane Extracts of Strychnos henningsii Gilg. and Ficus sycomorus L.

Wafula

Mworia

Ngugi

2023

The Scientific World Journal

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Medicinal plants are a rich source of antioxidants such as flavonoids, phenols, tannins, and alkaloids among others and are currently used as alternative and complementary drugs in the management of stress-related disorders. Strychnos henningsii and Ficus sycomorus have been traditionally used by the people of Mbeere, Embu county, Kenya, as medicine for the treatment of various oxidative stress-related disorders such as diabetes and rheumatism; however, no empirical data are available to authenticate the said claim. The aim of this study was to evaluate preliminary phytochemical screening and in vitro antioxidant activity of dichloromethane (DCM) leaf extract of S. henningsii and stem bark extract of F. sycomorus using DPPH, hydrogen peroxide, and ferric reducing power assays; total flavonoids and phenolic compounds were also determined by colorimetric assay and Folin–Ciocalteu reaction, respectively. Phytochemical screening showed that both extracts possessed saponins, flavonoids, phenols, steroids, alkaloids, and cardiac glycosides; however, terpenoids were found to be absent in S. henningsii. The total phenolic and flavonoid content of the DCM stem bark extract of F. sycomorus was lower than that of the leaf extract of S. henningsii. These extracts significantly exhibited strong antioxidant activities at different concentrations tested. The IC50 values of S. henningsii and F. sycomorus were 0.325 mg/ml and 0.330 mg/ml for hydrogen peroxide and 0.068 mg/ml and 0.062 mg/ml for DPPH, respectively. Both DCM leaf and stem bark extracts of S. henningsii and F. sycomorus were found to have strong ferric reducing power. Therefore, both extracts showed significant nonenzyme-based antioxidant activities. The two plants possess phytochemicals that have significant antioxidant properties.

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“…According to toxicological studies, enzymes are a common target of toxicants (Karaca et al, 2010). Enzymes are metabolic functional units (Zammit & Newsholme, 1979, Kumar et al, 2022. Oxidative enzymes are essential in respiratory metabolism (Coutinho & Gokhale, 2000, Natarajan, 1984, Barathinivas et al, 2022.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activities of Moringa Oleifera Leaf Extract Against Arsenic Induced Toxicity in Cirrhinus Mrigala

Azhar,

Anjum,

Anwar

et al. 2023

Pak. J. Biotechnol

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This experimental study was conducted to evaluate the antioxidant activities of Moringa oleifera leaf extract against Arsenic (As) induced toxicity in Cirrhinus mrigala in Tawakkal Fish Hatchery at Muzaffargarh, Punjab, Pakistan. 288 fingerlings were collected from fish pond and kept in circular tank for acclimatization. 12 fish about 100-day old having similar size were selected randomly and kept in separate glass aquaria for each treatment groups T1, T2, T3 and control group T4. Fish in treatments groups T1, T2 and T3 were exposed with water born sublethal concentration of 1/10th LC50 of arsenic (As) for 7days (240 hours). On 8th and 16th days of the experiment three fish were collected from each aquarium, humanly dissected targeted organ was taken out and used for liver, muscle, and gills antioxidant enzyme activities and histopathological alteration. The findings indicate that in treatment group T2 which feed with 2% and 4% Moringa oleifera supplemented diet reduced significantly (P<0.05) arsenic induced oxidative stress in fish, enhance the superoxide dismutase and catalase activities but treatment group T2 is 2% Moringa oleifera supplemented diet is more effective near to control group T4 as compared to treatment group T3 with 4% Moringa oleifera supplemented. After 16 days exposure of 1/10th concentration of arsenic with 0% Moringa oleifera various degenerative alteration were seen in gills. In 2% and 4% Moringa oleifera with 1/10th arsenic, spiked secondary lamellae and lamellar epithelium lifting (EL) and rupture of epithelial layer (↑↑) and fusion of lamellae were observed at several points. Moringa oleifera is medicinal herb, which has various tremendous benefits.

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Toxicity ameliorative effect of vitamin E against super-paramagnetic iron oxide nanoparticles on haemato-immunological responses, antioxidant capacity, oxidative stress, and metabolic enzymes activity during exposure and recovery in Labeo rohita fingerlings

Cited by 9 publications

References 124 publications

Transcriptomic, histological and biochemical analyses of Macrobrachium nipponense response to acute heat stress

Transcriptomic, histological and biochemical analyses of Macrobrachium nipponense response to acute heat stress

Phytochemical Screening and In Vitro Evaluation of the Antioxidant Potential of Dichloromethane Extracts of Strychnos henningsii Gilg. and Ficus sycomorus L.

Antioxidant Activities of Moringa Oleifera Leaf Extract Against Arsenic Induced Toxicity in Cirrhinus Mrigala

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