Toxicity and antioxidant capacity of Frangula alnus Mill. bark and its active component emodin

Brkanac, Sandra Radić; Gerić, Marko; Gajski, Goran; Vujčić, Valerija; Garaj‐Vrhovac, Vera; Kremer, Dario; Domijan, Ana-Marija

doi:10.1016/j.yrtph.2015.09.025

Cited by 36 publications

(25 citation statements)

References 34 publications

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“…The bark is widely used in traditional as well as modern medicine as laxative (Council of Europe, 2008). These laxative properties of the bark have been attributed to frangulins, anthraquinone glycoside derivatives, anthraquinone monoglycosides (emodin) and glucofrangulins components [ 11 , 12 ]. For example, the bark extract of F. alnus (Croatian origin) showed moderate antioxidant effects attributed to emodin [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…These laxative properties of the bark have been attributed to frangulins, anthraquinone glycoside derivatives, anthraquinone monoglycosides (emodin) and glucofrangulins components [ 11 , 12 ]. For example, the bark extract of F. alnus (Croatian origin) showed moderate antioxidant effects attributed to emodin [ 12 ]. Another study revealed that the bark extracts had strong antibacterial activities against Staphyllococcus aureus [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Polyphenols of Frangula alnus and Peganum harmala Leaves and Associated Biological Activities

Elansary

Szopa

Kubica

et al. 2020

Plants

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Frangula alnus and Peganum harmala populations growing in Saudi Arabia might be rich sources of natural compounds with important biological activities. A high performance liquid chromatography diode array revealed several polyphenols in the leaf extracts for the first time, including p-coumaric acid, rosmarinic acid, chlorogenic acid, ferulic acid, quercitrin, rutoside, quercetin and trifolin in F. alnus; and hydrocaffeic acid, protocatechuic acid, rosmarinic acid, caffeic acid and cynaroside in P. harmala. F. alnus and P. harmala showed strong antioxidant effects attributed to the polyphenolic composition of leaves and reduction of reactive oxygen species (ROS) accumulation. F. alnus and P. harmala leaf extracts showed cytotoxic effects against Jurkat, MCF-7, HeLa, and HT-29 cancer cells using MTT and flow cytometry assays. These activities were attributed to the polyphenolic composition of leaves including quercitrin, trifolin and cymaroside, as well as the activation of caspase family enzymes 2, 6, 8 and 9 in treated cancer cells compared to control. The current findings of this study include a novel comprehensive investigation on the polyphenol composition and anticancer effects of leaf extracts of F. alnus and P. harmala from natural populations in Saudi Arabia.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polyphenols of Frangula alnus and Peganum harmala Leaves and Associated Biological Activities

Elansary

Szopa

Kubica

et al. 2020

Plants

View full text Add to dashboard Cite

show abstract

“…Since Frangula Alnus miller extract possess moderate antioxidant capacity [36], it may have protective effects on healthy cells. Frangula Alnus leaf litter has also antimicrobial effects [37].…”

Section: Discussionmentioning

confidence: 99%

“…According to previous studies, antioxidant properties of the bark extract were attributed to its high phenolic and flavonoids content [18], [34]. Results of a study on antioxidant activity showed that, unlike emodin, bark extract possess moderate antioxidant capacity (44.6%, 46.8% and 2.25 mmol Fe2+/g measured by DPPH, ABTS and FRAP assay, respectively) that can be related to relatively high phenolic content (116.07 mg/g) [34].…”

Section: Introductionmentioning

confidence: 97%

“…Results of a study on antioxidant activity showed that, unlike emodin, bark extract possess moderate antioxidant capacity (44.6%, 46.8% and 2.25 mmol Fe2+/g measured by DPPH, ABTS and FRAP assay, respectively) that can be related to relatively high phenolic content (116.07 mg/g) [34]. The results of stdies about antioxidant and antimicrobial activity of F. rupestris and F. alnus bark has shown that oth species demonstrated excellent antioxidant and antimicrobial activities [18].…”

Section: Introductionmentioning

confidence: 99%

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