Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community

Strungaru, Ștefan-Adrian; Plăvan, Gabriel; Ciobîcă, Alin; Nicoară, Mircea; Robea, Madalina Andreea; Solcan, Carmen; Petrovici, Adriana

doi:10.1016/j.ecoenv.2019.01.057

Cited by 48 publications

(27 citation statements)

References 45 publications

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“…Bio-absorption of pyrethroids was detected in the urine samples of outdoor workers in California (Sullivan et al, 2019), which indicates the importance of this topic. In rats, the developmental of bifenthrin neurotoxicity was reported as mixed type (typeI/II) (Gammon et al, 2019) whereas non-target neurotoxicity of pyrethroids has also been investigated in zebrafish (Paravani et al, 2017; Awoyemi et al, 2019; Strungaru et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Insight Into Microbial Applications for the Biodegradation of Pyrethroid Insecticides

et al. 2019

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Pyrethroids are broad-spectrum insecticides and presence of chiral carbon differentiates among various forms of pyrethroids. Microbial approaches have emerged as a popular solution to counter pyrethroid toxicity to marine life and mammals. Bacterial and fungal strains can effectively degrade pyrethroids into non-toxic compounds. Different strains of bacteria and fungi such as Bacillus spp., Raoultella ornithinolytica, Psudomonas flourescens , Brevibacterium sp., Acinetobactor sp., Aspergillus sp., Candida sp., Trichoderma sp., and Candia spp., are used for the biodegradation of pyrethroids. Hydrolysis of ester bond by enzyme esterase/carboxyl esterase is the initial step in pyrethroid biodegradation. Esterase is found in bacteria, fungi, insect and mammalian liver microsome cells that indicates its hydrolysis ability in living cells. Biodegradation pattern and detected metabolites reveal microbial consumption of pyrethroids as carbon and nitrogen source. In this review, we aim to explore pyrethroid degrading strains, enzymes and metabolites produced by microbial strains. This review paper covers in-depth knowledge of pyrethroids and recommends possible solutions to minimize their environmental toxicity.

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Section: Introductionmentioning

confidence: 99%

Insight Into Microbial Applications for the Biodegradation of Pyrethroid Insecticides

et al. 2019

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“…This was evaluated by measuring specific parameters like total distance and swimming velocity. Generally, the time spent as moving/freezing represents the anxiety level [ 55 , 56 ]. From the results, the control group did not show significant changes for the total distance traveled between pretreatment days and exposure period (691.05 ± 64.2 cm vs. 719.66 ± 84.9 cm, p > 0.05 ANOVA).…”

Section: Resultsmentioning

confidence: 99%

“…Before the experimental study was started, each group was evaluated in the swimming performance and social tests. These initial tests were conducted to demonstrate the normal behavior of each group before the treatment since previous studies shown that zebrafish had a high behavioral variability between each specimen which resulted in significant differences between the untreated groups [ 54 , 55 , 56 ]. This test was done after the accommodation period from 10 a.m. to 8 p.m. and repeated for 4 days.…”

Section: Methodsmentioning

confidence: 99%

Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile

et al. 2020

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Chronic exposure to synthetic insecticides in the early life of a child can lead to a series of disorders. Several causes as parental age, maternal smoking, birth complications, and exposure to toxins such as insecticides on childhood can lead to Autism spectrum disorder (ASD) occurrence. The aim of this study was to evaluate the potential protective role of vitamin C (Vit. C) from children’s supplements after 14 days chronic exposure to insecticide mixture fipronil (Fip) + pyriproxyfen (Pyr) on juvenile zebrafish for swimming performances, social behavior and oxidative stress associated with ASD model. Juvenile (14–17 mm) wild-type AB zebrafish (Danio rerio) (45 days) were exposed to relevant concentrations: vit. C (25 µg L−1), Fip (600 µg L−1/1.372 μM) + Pyr (600 µg L−1/1.89 μM), and [Fip (600 µg L−1/1.372 μM) + Pyr (600 µg L−1 /1.89 μM)] + vit. C (25 µg L−1). Our results showed that insecticides can disturb the social behavior of zebrafish during 14 days of the administration, decreased the swimming performances, and elevated the oxidative stress biomarkers of SOD (superoxide dismutase), GPx (glutathione peroxidase), and MDA (malondialdehyde). The vitamin C supplement significantly attenuated the neurotoxicity of insecticide mixture and oxidative stress. This study provides possible in vivo evidence to show that vitamin C supplements could attenuate oxidative stress and brain damage of fipronil and pyriproxyfen insecticide chronic exposure on zebrafish juvenile.

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“…Apoptosis is a process of cells organizing self-destruction (Chen et al, 2007). Numerous studies have demonstrated that DLM can cause neuronal apoptosis (Huang et al, 2019;Liu et al, 2018;Strungaru et al, 2019). In this study, we explored the relationship among quail cerebrum neuronal apoptosis, mitochondrial, and ER.…”

Section: Discussionmentioning

confidence: 99%

Deltamethrin Induces Apoptosis in Cerebrum Neurons of Quail via Promoting Endoplasmic Reticulum Stress and Mitochondrial Dysfunction

Han

Yang

et al. 2021

Preprint

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Deltamethrin (DLM) is a widely used and highly effective insecticide. DLM exposure is harmful to animal and human. Quail, as a bird model, has been widely used in the toxicology field. However, there is little information available in the literature about quail cerebrum damage caused by DLM. Here, we investigated the effect of DLM on quail cerebrum neurons. Four groups of healthy quails were assigned (10 quails in each group), respectively given 0, 15, 30, and 45 mg/kg DLM by gavage for 12 weeks. Through the measurements of quail cerebrum, it was found that DLM exposure induced obvious histological changes, oxidative stress, and neurons apoptosis. To further explore the possible molecular mechanisms, we performed real-time quantitative PCR to detect the expression of endoplasmic reticulum (ER) stress-related mRNA. In addition, we detected ATP content in quail cerebrum to evaluate the functional status of mitochondria. The study showed that DLM exposure significantly increased the expression of ER stress-related mRNA and decreased ATP content in quail cerebrum. These results suggest that chronic exposure to DLM induces apoptosis of quail cerebrum neurons via promoting ER stress and mitochondrial dysfunction. Furthermore, our results provide a novel explanation for DLM-induced apoptosis of avian cerebrum neurons.

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Toxicity and chronic effects of deltamethrin exposure on zebrafish (Danio rerio) as a reference model for freshwater fish community

Cited by 48 publications

References 45 publications

Insight Into Microbial Applications for the Biodegradation of Pyrethroid Insecticides

Insight Into Microbial Applications for the Biodegradation of Pyrethroid Insecticides

Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile

Deltamethrin Induces Apoptosis in Cerebrum Neurons of Quail via Promoting Endoplasmic Reticulum Stress and Mitochondrial Dysfunction

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