Toxicity and the cardiovascular activity of organotin compounds: a review

Nath, Mala

doi:10.1002/aoc.1436

Cited by 124 publications

(68 citation statements)

References 106 publications

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“…Although the biological activity of these compounds was desirable for many applications, some issues associated with their harmful impact on the environment were also raised [3,4]. More recently, the possibility of using some organotin(IV) compounds in medicine has become the focus of extensive exploration [5,6]. In the area of academic research, organotin(IV) compounds are considered to be reagents valuable for laboratory organic synthesis, e.g., in various reduction, transmetallation, and coupling reactions [1,7].…”

Section: Introductionmentioning

confidence: 99%

Theoretical investigation of the N → Sn coordination in (Me3SnCN)2

Matczak

2014

Struct Chem

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The N → Sn coordination occurring in the (Me 3 SnCN) 2 dimer has been investigated using various computational methods and several theoretical tools possessing great interpretative potential. The dimer is formed by moving the C≡N fragment of the first Me 3 SnCN molecule close to the Sn atom of the second molecule and the resulting N → Sn coordination corresponds to that observed in the crystal structure of trimethyltin cyanide. The geometry of (Me 3 SnCN) 2 is optimized using the MP2 method and its 11 variants, and then it is compared with the reference geometry obtained at the CCSD level of theory. SCS-MP2 reproduces best the reference geometry of (Me 3 SnCN) 2 and its accuracy is close to that of the MP4 (SDQ) method. Two families of basis sets, namely the correlation-consistent basis sets proposed by Dunning and co-workers and the 'def2' basis sets developed by Ahlrichs and co-workers, are taken into account and their effect on the geometry of the dimer is examined in detail. The intermolecular interaction in (Me 3 SnCN) 2 has been analyzed using SAPT, NBO, QTAIM, and ELF. The results indicate that the (Me 3 SnCN) 2 dimer possesses a weak N → Sn coordination bond whose character is predominantly ionic. A value of −7.64 kcal/mol is proposed to be the best estimate of the interaction energy between the Me 3 SnCN molecules in the dimer.

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Section: Introductionmentioning

confidence: 99%

Theoretical investigation of the N → Sn coordination in (Me3SnCN)2

Matczak

2014

Struct Chem

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“…杨志强等在对 Bu n Cy 3-n SnX 类化合物研究中, 发现其杀虫和杀菌随着 n 的变化而变化, 当 n＝2 时, 这类化合物同时兼有较高的杀菌和杀螨活性 [6] . 另一方面, 由于有机锡化合物在实际应用过程中表现一定程度的毒副作用 [7,8] , 因此, 人们合成了各种不同结构的有机锡化合物, 并对它们的结构和生物活性作了广泛的研究, 得到了很多有意义的结果 [9～11] . 谢庆兰等 [12] 合成了一系列含硅三烃基锡化合物并对其进行研究, 发现该类化合物在保留较强杀螨活性的同时, 还可能减少其副作用.…”

Section: 许多三烃基锡化合物由于具有一定的生物活性已被广泛作为杀螨剂、杀虫剂和杀菌剂应用于农业生产中如杀菌剂薯瘟锡(三unclassified

Syntheses and Characterization of Cyclohexyl(phenyl)-[(trimethylsilyl)methyl]stannyl Aromatic Carboxylates

龚根飞¹,

宋冉²,

邹引波³

et al. 2013

Chin. J. Org. Chem.

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“…Organotin compounds [1][2][3][4] are important for many reasons including their use as stabilizers for polyvinyl chloride plastics [5][6][7][8], as anti-tumor drugs [9][10][11][12], as anti-fungal agents [13], and as neuroprotective agents [14]. In organic synthesis, they are used in many types of reactions, notably in Stille coupling [15], as reagents that promote regioselective substitution [16,17], and as catalysts [18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%