Toxicity Assessment in the Nanoparticle Era

Matteis, Valeria De; Rinaldi, R.

doi:10.1007/978-3-319-72041-8_1

Cited by 67 publications

(53 citation statements)

References 134 publications

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“…Similarly, a definition of "nanoparticle" is a "nano-object with all three external dimensions in the nanoscale" where nanoscale was defined as size ranging from 1 nm to 100 nm (ISO, 2008) [33]. NPs can be obtained by many synthetic routes, starting from chemical elements such as carbon, metals, metal oxide, biological molecules, and polymers [34]. The biological effects are strongly affected by physico-chemical properties of NPs such as surface charge, size, shape, and solubility.…”

Section: Physico-chemical Properties Of Nanomaterialsmentioning

confidence: 99%

Noble Metals and Soft Bio-Inspired Nanoparticles in Retinal Diseases Treatment: A Perspective

Matteis

Rizzello

2020

Cells

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We are witnessing an exponential increase in the use of different nanomaterials in a plethora of biomedical fields. We are all aware of how nanoparticles (NPs) have influenced and revolutionized the way we supply drugs or how to use them as therapeutic agents thanks to their tunable physico-chemical properties. However, there is still a niche of applications where NP have not yet been widely explored. This is the field of ocular delivery and NP-based therapy, which characterizes the topic of the current review. In particular, many efforts are being made to develop nanosystems capable of reaching deeper sections of the eye such as the retina. Particular attention will be given here to noble metal (gold and silver), and to polymeric nanoparticles, systems consisting of lipid bilayers such as liposomes or vesicles based on nonionic surfactant. We will report here the most relevant literature on the use of different types of NPs for an efficient delivery of drugs and bio-macromolecules to the eyes or as active therapeutic tools.

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Section: Physico-chemical Properties Of Nanomaterialsmentioning

confidence: 99%

Noble Metals and Soft Bio-Inspired Nanoparticles in Retinal Diseases Treatment: A Perspective

Matteis

Rizzello

2020

Cells

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“…Human is exposed to different non-scale materials since the new developing field of nanotechnology has turned into another danger to human life [11,12]. The proposed hypothesis is that the NPs of size under 10 nm act similar to gas and can enter human tissues effectively and may abrogate the cell typical biochemical condition [11,13]. There have been studies on human and murine models that the NPs are exposed through orally they are circulated to the spleen, liver, heart The following figure represents usages of nanotechnology/nanoparticles in different field [6].…”

Section: Nanoparticle As a Threatmentioning

confidence: 99%

“…AgNPs disrupts the membrane proteins integrity of the mitochondria, also hampers the membrane permeability of the membrane and abrogate the mitochondrial functions ( Figure 6). Nanoparticles pathway and toxicological impact [13,14].…”

Section: Toxicity Of Silver Nanoparticlesmentioning

confidence: 99%

Cellular and Molecular Impact of Green Synthesized Silver Nanoparticles

Patel¹,

Kumari²,

Verma³

et al. 2020

Engineered Nanomaterials - Health and Safety

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Toxicity and biocompatibility of silver nanoparticles are of a major concern due to their extensive production regardless of their application in current industries. Information about toxicology or biocompatibility is crucial regarding their proper utilization and application in clinical as well as environmental aspect. This chapter describes in detail about the different techniques and technology of synthesis of silver nanoparticles and explains their different physiochemical properties in context of the current research scenario. Further, it also explains the biocompatibility and toxicity of silver nanoparticles at cellular and molecular aspects. The mechanism of their toxicity has been described keeping in view of the recent research done. In brief, it reveals detail knowledge of the cellular and molecular impact of silver nanoparticles.

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“…Specific literature about the toxicity of therapeutic nanoparticles in the eye remains scarce [243]. Nanotoxicity is a subject of key importance to be determined in conjunction with the therapeutic potential of each nanoparticle [245,246], particularly for those that require repeat-dose regimens [247]. All nanoparticles proposed to be utilized for therapeutic purposes must be thoroughly investigated in terms of local and systemic toxicity, before obtaining the full regulatory approval.…”

Section: Toxicity Of Nanomaterialsmentioning

confidence: 99%

Nanotechnology for Medical and Surgical Glaucoma Therapy—A Review

et al. 2019

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Glaucoma is the second leading cause of blindness worldwide. Even though significant advances have been made in its management, currently available antiglaucoma therapies suffer from considerable drawbacks. Typically, the success and efficacy of glaucoma medications are undermined by their limited bioavailability to target tissues and the inadequate adherence demonstrated by patients with glaucoma. The latter is due to a gradual decrease in tolerability of lifelong topical therapies and the significant burden to patients of prescribed stepwise antiglaucoma regimens with frequent dosing which impact quality of life. On the other hand, glaucoma surgery is restricted by the inability of antifibrotic agents to efficiently control the wound healing process without causing severe collateral damage and long-term complications. Evolution of the treatment paradigm for patients with glaucoma will ideally include prevention of retinal ganglion cell degeneration by the successful delivery of neurotrophic factors, anti-inflammatory drugs, and gene therapies. Nanotechnology-based treatments may surpass the limitations of currently available glaucoma therapies through optimized targeted drug delivery, increased bioavailability, and controlled release. This review addresses the recent advances in glaucoma treatment strategies employing nanotechnology, including medical and surgical management, neuroregeneration, and neuroprotection.

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Toxicity Assessment in the Nanoparticle Era

Cited by 67 publications

References 134 publications

Noble Metals and Soft Bio-Inspired Nanoparticles in Retinal Diseases Treatment: A Perspective

Noble Metals and Soft Bio-Inspired Nanoparticles in Retinal Diseases Treatment: A Perspective

Cellular and Molecular Impact of Green Synthesized Silver Nanoparticles

Nanotechnology for Medical and Surgical Glaucoma Therapy—A Review

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