Toxicity, formation, contamination, determination and mitigation of acrylamide in thermally processed plant-based foods and herbal medicines: A review

Fan, Min; Xu, Xiao‐Ying; Lang, William W.; Wang, Wenjing; Wang, Xinyu; 又信, 阿部; Zhou, Fangmei; Ding, Zhongxiang; Ye, Xiaoqing; Zhu, Bingqi

doi:10.1016/j.ecoenv.2023.115059

Cited by 21 publications

(6 citation statements)

References 148 publications

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“…ACR is more likely to accumulate when higher temperatures are used in the cooking process for longer periods of time (Lentz et al 2008). Besides, trace levels of acrylamide contaminants could be detected in some treated drinking water from natural water streams when polyacrylamide is used to purify water (Fan et al 2023).…”

Section: Acrylamide Structure and Resourcesmentioning

confidence: 99%

Acrylamide toxicity in aquatic animals and its mitigation approaches: an updated overview

Naiel,

Negm,

Ghazanfar

et al. 2023

Environ Sci Pollut Res

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Acrylamide (ACR) is widely applied in various industrial activities, as well as in the water purification process. Furthermore, ACR is synthesized naturally in some starchy grains exposed to high temperatures for an extended time during the cooking process. Because of its widespread industrial usage, ACR might be released into water stream sources. Also, ACR poses a high risk of contaminated surface and ground-water resources due to its high solubility and mobility in water. Furthermore, animal studies have indicated that ACR exposure may cause cancer (in many organs such as lung, prostate, uterus, and pancreas), genetic damage (in both somatic and germ cells), and severe effects on reproduction and development. Recently, numerous studies have shown that ACR has a mild acute cytotoxic impact on aquatic species, particularly during early life stages. Besides, wide-spectrum usage of ACR in many industrial activities presented higher environmental risks as well as major hazards to consumer health. This literature was designed to include all potential and accessible reports on ACR toxicity related with aquatic species. The Preferred Reporting Items for Systematic Reviews were applied to evaluate the risk effects of ACR on aquatic organisms, the ACR sub-lethal concentration in the ecosystem, and the possible protective benefits of various feed additives against ACR toxicity in fish. The major findings are summarized in Tables 2 and 3. The primary aim of this literature was to specify the hazards of ACR toxicity related with fish welfare and possible suggested strategies to reduce its risks.

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Section: Acrylamide Structure and Resourcesmentioning

confidence: 99%

Acrylamide toxicity in aquatic animals and its mitigation approaches: an updated overview

Naiel,

Negm,

Ghazanfar

et al. 2023

Environ Sci Pollut Res

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“…Acrylamide (AA) is a by-product of the Maillard reaction of asparagine with reducing sugars, such as glucose, galactose and fructose, at temperatures above 120 °C and peaking at around 170 °C [ 30 , 31 , 32 , 33 ]. AA is a genotoxic and neurotoxic compound, classified as level 2A since 1994 (probable human carcinogen) by the International Agency for Research on Cancer [ 34 , 35 , 36 ]. Coffee is one of the main contributors to the intake of this hazard, as the roasting and spray-drying stages play an essential role in forming AA [ 33 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Probabilistic Risk Assessment of Metals, Acrylamide and Ochratoxin A in Instant Coffee from Brazil, Colombia, Mexico and Peru

Guadalupe,

Grandez-Yoplac,

Arellanos

et al. 2024

Foods

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This study analysed the probabilistic risk to consumers associated with the presence of iAs, Cd, Cr, Hg, Pb, acrylamide (AA) and ochratoxin A (OTA) in instant coffee from Brazil, Colombia, Mexico and Peru. The results found iAs to be the metal with the highest concentrations (3.50 × 10−2 to 6.00 × 10−2 mg/kg), closely followed by Pb (1.70 × 10−2 to 2.70 × 10−2 mg/kg) and Cr (5.00 × 10−3 to 1.00 × 10−2 mg/kg), although these differences were not significant between countries. Cd and Hg were not detected. Focusing on AA, the concentrations ranged from 1.77 × 10−1 mg/kg (Peru) to 4.77 × 10−1 mg/kg (Brazil), while OTA ranged from 1.32 × 10−3 (Peru) to 1.77 × 10−3 mg/kg (Brazil) with significant differences between countries in both cases. As regards risk, the hazard quotient and hazard index were less than 1, meaning that the consumption of instant coffee represents a low level of concern for non-genotoxic effects. The results of the combination of margin of exposure and probability of exceedance indicated that the non-genotoxic effects of Pb, AA and OTA pose no threat. However, the probability values of suffering cancer from iAs and AA (between 1 × 10−6 and 1 × 10−4) indicated a moderate risk and that management measures should be taken.

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“…ACR has been identified as neurotoxic, genotoxic, carcinogenic, hepatotoxic, and reproductively toxic. (Chu et al, 2020;Fan et al, 2023;Wang et al, 2022;Zhang et al, 2023). However, currently only neurotoxicity has been demonstrated in animals and occupationally exposed humans (Matoso et al, 2019;Pennisi et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Reduction of eEF2 kinase alleviates the learning and memory impairment caused by acrylamide

Wang,

Zhang,

Pan

et al. 2024

Preprint

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The impact of acrylamide (ACR) on learning and memory has garnered considerable attention. However, the targets and mechanisms are still unclear. We used proteomics technology to analyze the serum of the ACR occupationally exposed population and screen out target proteins related to learning and memory. Through in vivo, in vitro experiments, and transgenic mouse models, we investigated the selected target protein to elucidate. Elongation factor 2 (eEF2) was significantly upregulated in the results of serum proteomic. Results from in vitro and in vivo experiments indicated a notable upregulation of Eukaryotic elongation factor 2 kinase (eEF2K), the sole kinase responsible for eEF2 phosphorylation, following exposure to ACR (P < 0.05). Subsequent in vitro experiments using eEF2K siRNA and in vivo experiments with eEF2K-knockout mice demonstrated significant improvements in abnormal indicators related to ACR-induced learning and memory deficits (P < 0.05). Proteomic analysis of the hippocampus revealed Lpcat1 as a crucial downstream protein regulated by eEF2K. KEGG analysis indicated that eEF2K may play a role in the process of ACR-induced learning and memory impairment by affecting ether lipid metabolism. In summary, eEF2K as a pivotal target in the mechanisms underlying ACR-induced learning and memory impairment, providing robust evidence for potential clinical interventions targeting.

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Toxicity, formation, contamination, determination and mitigation of acrylamide in thermally processed plant-based foods and herbal medicines: A review

Cited by 21 publications

References 148 publications

Acrylamide toxicity in aquatic animals and its mitigation approaches: an updated overview

Acrylamide toxicity in aquatic animals and its mitigation approaches: an updated overview

Probabilistic Risk Assessment of Metals, Acrylamide and Ochratoxin A in Instant Coffee from Brazil, Colombia, Mexico and Peru

Reduction of eEF2 kinase alleviates the learning and memory impairment caused by acrylamide

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