Toxicity studies on Trigonella foenum-graecum L. seeds used in spices and as a traditional remedy for diabetes

Abstract

SUMMARYAcute (24 h) and chronic (90 days) oral toxicity studies on the ethanol extract of Trigonella foenumgraecum Leguminosae (L.) seeds were carried out. Acute dosages were 0.5, 1.0 and 3 g/kg while chronic dosage was 100 mg/kg per day of the extract. All morphological, biochemical, haematological and spermatogenic changes, in addition to mortality, body weight changes and any change in vital organs were recorded. Histopathological investigations were done on vital organs. Growth arrest in the treated animals was observed. The treated mice gained no significant weight during chronic treatment while there was a significant gain in body weight of the control group mice. Biochemical studies revealed a significant decrease in blood sugar levels of fenugreek treatment groups while haematological parameters remained comparable to the control. In the treatment, male group there was a significant decrease in weight of testes as compared to the control. There was a marginal weight gain in kidney weight of mice after chronic treatment as compared to the control. Fenugreek chronic treatment caused a highly significant spermatotoxic effects in male mice.

Galactomannan More than Pectin Exacerbates Liver Injury in Mice Fed with High‐Fat, High‐Cholesterol Diet

“…Information regarding galactomannan toxicity is almost negligible. In addition, fenugreek seeds have been consumed for many years without any reports of liver damage or histopathology involving vital organs such as the liver . However, it was also demonstrated that rats administered fenugreek seeds for 4 weeks at doses of 100, 150, or 200 mg kg –1 exhibited necrotic effects involving the liver and kidney tissue .…”

Toxicity Effect by Binahong (Anredera cordifolia) Leaf Extract in Histopathology and Liver Weight of Guinea Pigs (Cavia cobaya)

“…Flavonoids help maintain liver function to keep warding off toxins caused by free radicals and drugs. Heavier organ weights indicate the occurrence of steatosis, which is fatty in liver cells which is seen as a symptom of toxic effects directly (Al-Ashban et al, 2010). Changes in heart weight are not always fatal (critical), because the liver is an organ that has tremendous growth capacity (Korani et al, 2011).…”

Antibacterial, antioxidant and antidiabetic activities of Gmelina arborea roxb fruit extracts

“…[31][32][33] Two days after of alloxan injection, rats with plasma glucose levels of more than 200 mg/dl were included in the study and at this stage the blood glucose level of each rat was consider as basal value in each group. Treatment with plant extracts and standard drug was started after 48 h of alloxan injection.…”