Toxicogenomics Applied to Ecological Risk Assessment

Villeneuve, Daniel L.; Ankley, Gerald T.; Martinović, Dalma

doi:10.1002/9781118001042.ch10

Cited by 1 publication

(1 citation statement)

References 113 publications

(174 reference statements)

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“…This approach establishes a basis upon which concepts and testable hypotheses, to be tested by multi-disciplinary fields of study, can be constructed. Examples of such studies include those of Villeneuve et al [ 136 ] who provide a review of the integration of toxicogenomics, as a complementary tool to traditional methodologies, when applied to risk assessment. Altenburger et al [ 114 ] highlight the use of omics technology for mixture studies, stressing the need for dose and time mixture toxicity models that include bioinformatics and stress response concepts that can integrate the multiple responses into testable hypotheses.…”

Section: From Genes To Populationsmentioning

confidence: 99%

Effect-Based Tools for Monitoring and Predicting the Ecotoxicological Effects of Chemicals in the Aquatic Environment

Connon

Geist

Werner

2012

Sensors

248

113

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Ecotoxicology faces the challenge of assessing and predicting the effects of an increasing number of chemical stressors on aquatic species and ecosystems. Herein we review currently applied tools in ecological risk assessment, combining information on exposure with expected biological effects or environmental water quality standards; currently applied effect-based tools are presented based on whether exposure occurs in a controlled laboratory environment or in the field. With increasing ecological relevance the reproducibility, specificity and thus suitability for standardisation of methods tends to diminish. We discuss the use of biomarkers in ecotoxicology including ecotoxicogenomics-based endpoints, which are becoming increasingly important for the detection of sublethal effects. Carefully selected sets of biomarkers allow an assessment of exposure to and effects of toxic chemicals, as well as the health status of organisms and, when combined with chemical analysis, identification of toxicant(s). The promising concept of “adverse outcome pathways (AOP)” links mechanistic responses on the cellular level with whole organism, population, community and potentially ecosystem effects and services. For most toxic mechanisms, however, practical application of AOPs will require more information and the identification of key links between responses, as well as key indicators, at different levels of biological organization, ecosystem functioning and ecosystem services.

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Section: From Genes To Populationsmentioning

confidence: 99%