Toxicological considerations for the medicinal chemist

Finch, N.

doi:10.1002/med.2610010403

Cited by 9 publications

(6 citation statements)

References 71 publications

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“…In fact, it is the metabolites of many toxic chemical substances that, ironically, are responsible for the toxicity. This phenonmenon, the conversion of a chemical substance into a toxic metabolite, is known as bioactivation and is the basis of toxicity of many chemical substances (3)(4)(5)9,(18)(19)(20)(21)(22)(23)(24)(25). A major element of designing safer chemicals is controlling bioactivation; that is, by adding molecular modifications to direct metabolism away from bioactivation and toward detoxication.…”

Section: Toxicological Considerations For Chemistsmentioning

confidence: 99%

General Principles for the Design of Safer Chemicals: Toxicological Considerations for Chemists

DeVito

1996

ACS Symposium Series

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Section: Toxicological Considerations For Chemistsmentioning

confidence: 99%

General Principles for the Design of Safer Chemicals: Toxicological Considerations for Chemists

DeVito

1996

ACS Symposium Series

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“…1 Over the past 35 years many comprehensive treatises devoted to the design of safer chemicals have been published, [2][3][4][5][6][7][8][9][10][11][12][13] and some chemical companies devote considerable resources to the development of safer commercial chemicals. 1 Over the past 35 years many comprehensive treatises devoted to the design of safer chemicals have been published, [2][3][4][5][6][7][8][9][10][11][12][13] and some chemical companies devote considerable resources to the development of safer commercial chemicals.…”

Section: Introductionmentioning

confidence: 99%

“…What are its characteristics? [2][3][4][5][6][7][8][9][10][11][12][13] Use potency. These fundamental but often overlooked questions must be addressed at the very beginning of the design phase of any new chemical substance.…”

Section: Introductionmentioning

confidence: 99%

“…Contrary to the false but widespread belief that the designing safer chemicals paradigm evolved from the field of green chemistry, the importance for commercial chemicals to be designed such that they are of low toxicity and commercially viable was emphasized nearly a century ago by Alice Hamilton. 1 Over the past 35 years many comprehensive treatises devoted to the design of safer chemicals have been published, [2][3][4][5][6][7][8][9][10][11][12][13] and some chemical companies devote considerable resources to the development of safer commercial chemicals. 9,14 Many specific and detailed examples on how timehonored approaches used by medicinal chemists to design safer, clinically efficacious pharmaceutical substances can be applied to the design of safer commercial chemicals are provided in publications by Ariëns 2,4,7 and DeVito.…”

Section: Introductionmentioning

confidence: 99%

“…Insights on how some of these characteristics can be designed into a molecule are available elsewhere. [2][3][4][5][6][7][8][9][10][11][12][13] Use potency. Good use potency, the very first characteristic of the ideal chemical (Fig.…”

Section: Introductionmentioning

confidence: 99%

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On the design of safer chemicals: a path forward

DeVito

2016

Green Chem.

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The need for chemists to design chemicals that not only fulfill their intended purposes but are of minimal hazard was recognized nearly a century ago. Over the decades regulations pertaining to the development of safer drug substances and pesticides have been promulgated, and caused changes in the relationships between industry, academia, government agencies, and how chemists are trained to develop new pesticides and new drug substances. This has led to the considerable progress that has occurred over the past 60 years in the development of safe and efficacious pharmaceuticals and pesticides. Progress in the design of safer commercial chemicals, however, has been comparatively slow, despite the many advances in: toxicological research; the elucidation of mechanisms of toxicity; and the identification of relationships between chemical structure, physicochemical and electronic properties with toxicity, environmental fate, or environmental hazard. While few would argue against the need for safer commercial chemicals, implementation of the design of safer chemicals as a paradigm has not advanced to the same extent as other approaches to preventing pollution. This article offers insights on how this paradigm can be advanced as an important component of sustainable development, and how those existing commercial chemicals for which safer, commercially viable alternatives are most needed can be identified and prioritized. One recommendation regarding prioritization is the use of information available in the United States (U.S.) Environmental Protection Agency's (EPA's) Toxics Release Inventory (TRI): the U.S.' pollutant release and transfer register (PRTR). The TRI is an easy-to-use pollution prevention database tool used extensively for tracking the quantities of toxic chemicals annually released or otherwise managed as waste, and evaluating overall environmental performance by industrial facilities. Other PRTRs throughout the world have the potential to be used for identification and prioritization of chemicals as well.

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The Design of Safer Chemicals: Past, Present, and Future Perspectives

DeVito

2012

Handbook of Green Chemistry

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The sections in this article are Evolution of the Concept In the Development of Drug Substances: Emergence of the Medicinal Chemist In the Development of Pesticide Substances In the Development of Industrial Chemical Substances Stagnation of the Concept Because of Section 5 of the TSCA Characteristics of a “Safer Chemical” Types of Safer Chemicals The Ideal Chemical The Future of the Concept Disclaimer

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Toxicological considerations for the medicinal chemist

Cited by 9 publications

References 71 publications

General Principles for the Design of Safer Chemicals: Toxicological Considerations for Chemists

General Principles for the Design of Safer Chemicals: Toxicological Considerations for Chemists

On the design of safer chemicals: a path forward

The Design of Safer Chemicals: Past, Present, and Future Perspectives

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