2013
DOI: 10.1016/j.fct.2013.09.027
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Toxicology of some important medicinal plants in southern Africa

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Cited by 73 publications
(40 citation statements)
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References 80 publications
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“…When looking for new drugs, besides biological activity, it is important to verify that the drug is not harmful to human cells (Ndhlala et al, 2013). Some tests, such as the comet assay, are able to identify genotoxic agents and substances having potential risks to human health.…”
Section: Discussionmentioning
confidence: 99%
“…When looking for new drugs, besides biological activity, it is important to verify that the drug is not harmful to human cells (Ndhlala et al, 2013). Some tests, such as the comet assay, are able to identify genotoxic agents and substances having potential risks to human health.…”
Section: Discussionmentioning
confidence: 99%
“…Phytochemical investigations of Vernonia spp., both in America and Africa, have resulted in the isolation of numerous classes of cytotoxic sesquiterpene lactones with potent biological activities. 18,30 Glaucolides, hirsutinolide derivatives, and related sesquiterpene lactones have been isolated from South American poisonous V. nudiflora and V. mollissima. 3,6 However, despite the hundreds of terpenoids isolated from the Vernonia genus, only a limited number have been tested for toxicity, and it is not certain which phytochemical is responsible for the hepatotoxic effects.…”
Section: Discussionmentioning
confidence: 99%
“…A gravidade de um efeito tóxico pode depender da via de administração, da fase de crescimento ou parte da planta, a quantidade consumida, as espécies e a susceptibilidade da vítima. A solubilidade da toxina nos fluidos corporais, a frequência de intoxicação, bem como a idade da vitima, também são fatores que podem influenciar na toxicidade das plantas (NDHLALA et al, 2013).…”
Section: Introductionunclassified