Toxin effect on protein biosynthesis in eukaryotic cells: A simple kinetic model

Skakauskas, Vladas; Katauskis, Pranas; Skvortsov, Alex; Gray, Peter J.

doi:10.1016/j.mbs.2014.12.004

Cited by 2 publications

(1 citation statement)

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“…The development and production of new antibodies is an expensive process that usually includes extensive experimental studies. In order to reduce this experimental burden, a simple modeling framework has recently been proposed [6][7][8][9] that enables extensive studies to increase the protective potential of antibodies before proceeding with targeted experimental studies.…”

Section: Introductionmentioning

confidence: 99%

Modeling of toxin–antibody interaction and toxin transport toward the endoplasmic reticulum

Skakauskas

Katauskis

2015

J Biol Phys

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A model for toxin-antibody interaction and toxin trafficking towards the endoplasmic-reticulum is presented. Antibody and toxin (ricin) initially are delivered outside the cell. The model involves: the pinocytotic (cellular drinking) and receptor-mediated toxin internalization modes from the extracellular into the intracellular domain, its exocytotic excretion from the cytosol back to the extracellular medium, the intact toxin retrograde transport to the endoplasmic reticulum, the anterograde toxin movement outward from the cell across the plasma membrane, the lysosomal toxin degradation, and the toxin clearance (removal from the system) flux. The model consists of a set of coupled PDEs. Using an averaging procedure, the model is reduced to a system of coupled ODEs. Both PDEs and ODEs systems are solved numerically. Numerical results are illustrated by figures and discussed.

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Section: Introductionmentioning

confidence: 99%