TP53 R72P Polymorphism and Susceptibility to Human Papillomavirus Infection Among Women With Human Immunodeficiency Virus in Morocco: A Case-control Study

Lahsen, A. Oulad; Baba, Hanâ; Bensghir, Rajaa; Fayssel, Naouar; Sodqi, M.; Marih, L.; Nadifi, Sellama; Wakrim, Lahcen; Filali, Kamal Marhoum El; Ezzikouri, Sayeh

doi:10.15430/jcp.2017.22.4.248

Cited by 5 publications

(6 citation statements)

References 29 publications

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“…One of such genetic factors that increase susceptibility to HPV-associated cervical carcinogenesis is the TP53 R72P mutation ( 238 ), which was reported in Gabon, Senegal, Sudan, Morocco, and South Africa; and this risk increases when combined with the chromosomal allelic loss of RB or with aberrant methylation of DAPK1 , RARB , TWIST1 , and CDH13 ( 79 , 239 – 244 ). Furthermore, aberrant methylation of these genes was proposed by Feng et al ( 245 ) to be useful in Senegal for the screening of cervical cancer, either alone or in combination with cytology.…”

Section: Resultsmentioning

confidence: 99%

A Review of Cancer Genetics and Genomics Studies in Africa

Rotimi

Salhia

2021

Front. Oncol.

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Cancer is the second leading cause of death globally and is projected to overtake infectious disease as the leading cause of mortality in Africa within the next two decades. Cancer is a group of genomic diseases that presents with intra- and inter-population unique phenotypes, with Black populations having the burden of morbidity and mortality for most types. At large, the prevention and treatment of cancers have been propelled by the understanding of the genetic make-up of the disease of mostly non-African populations. By the same token, there is a wide knowledge gap in understanding the underlying genetic causes of, and genomic alterations associated with, cancer among black Africans. Accordingly, we performed a review of the literature to survey existing studies on cancer genetics/genomics and curated findings pertaining to publications across multiple cancer types conducted on African populations. We used PubMed MeSH terms to retrieve the relevant publications from 1990 to December 2019. The metadata of these publications were extracted using R text mining packages: RISmed and Pubmed.mineR. The data showed that only 0.329% of cancer publications globally were on Africa, and only 0.016% were on cancer genetics/genomics from Africa. Although the most prevalent cancers in Africa are cancers of the breast, cervix, uterus, and prostate, publications representing breast, colorectal, liver, and blood cancers were the most frequent in our review. The most frequently reported cancer genes were BRCA1, BRCA2, and TP53. Next, the genes reported in the reviewed publications’ abstracts were extracted and annotated into three gene ontology classes. Genes in the cellular component class were mostly associated with cell part and organelle part, while those in biological process and molecular function classes were mainly associated with cell process, biological regulation, and binding, and catalytic activity, respectively. Overall, this review highlights the paucity of research on cancer genomics on African populations, identified gaps, and discussed the need for concerted efforts to encourage more research on cancer genomics in Africa.

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Section: Resultsmentioning

confidence: 99%

A Review of Cancer Genetics and Genomics Studies in Africa

Rotimi

Salhia

2021

Front. Oncol.

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“…Several studies examined the relation between p53 gene polymorphism and the susceptibility to disease but the results of these studies are Contradictory, P53 polymorphism associated with the HPV infection and development of head and neck cancers 3 , development of oral cancer 14 and cervical cancer 19 , In contrast, some studies found the opposite result where the P53 gene poly-morphism are not associated with HPV infections ans lesion progressions 1 and development of skin cancer 20 .…”

Section: Discussionmentioning

confidence: 99%

“…P53 are tumor suppressor proteins which play an important role in regulation of cell cycles, maintenance of genomic integrities, and encounter of environmental insults and cell apoptosis in addition to controlling the innate immunity of viral infection by regulate several sensors and receptors 1 . These proteins are encoded by P53 genes which located in human chromosome 17 , a common single nucleotide polymorphism (SNP) located in this gene in codon 72 is the changing of CCC coding for Proline to CGC coding for Arginine, this polymorphism found in P53 region rich with Proline 2 .…”

Section: Introductionmentioning

confidence: 99%

“…HPV human papillomavirus is circular, double strand DNA viruses with genome size 8 Kb have eight proteins-coding genes including L1, L2 gene (which coding for the capsid proteins or structural proteins) E genes including E 1,2,4,5,6,7 coding for proteins which responsible for viral replication, transcription and transformation 4 . HPV belong to Papillomaviridea and over 130 different kind has been classified according to variation in L1 gene 5 HPV transmitted directly through skin to skin contact either in children or through the sexual rote infect skin cells and cause benign or malignant wart or skin lesions 6 .…”

Section: Introductionmentioning

confidence: 99%

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The Effectiveness of P53 Polymorphism in Susceptibility to Human Papillomavirus and Molluscum contagiosum Infections

Mughir¹,

Ibraheam²,

Al-Murshidi³

2019

J Pure Appl Microbiol

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P53 is Tumor suppressor gene which plays a main role in the genomic integrity preservation, mutation in this gene may change the susceptibility of individuals for several viral infections. This work designed to evaluate the effectiveness of P53 gene polymorphism (Arg/Pro) in susceptibility to infection with Molluscum contagiosum and Human Papillomavirus. Thirty one (31) invasive Molluscum contagiosum and 31 invasive Human Papillomavirus cases were studied and compared with 31 matched controls. Striking increase in (Arg/ Arg) and (Arg/ Pro) and decrease of (Pro/ Pro) genotype frequencies have been observed in MCV and HPV infected patients, by comparing with controls, we didn't find significant relation between this infection and P53 genotypes. By investigate the frequency of mutation (Pro/ Pro vs. Arg/ Arg and Arg/ Pro) we found significant increasing of (Arg/ Arg) and (Arg/ Pro) in MCV infected patients p=0.023<0.05.we found that the carrying of Arg allele be more susceptible to infect with MCV and HPV while Pro/Pro genotype may confer protection against this viruses in our population.

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“…A cross-sectional study was performed in 236 consecutive patients followed (or treated) at the Infectious Disease Center, University Hospital Center, Ibn Rochd (Casablanca, Morocco) from February 2013 to September 2018 as described previously [32,33]. All of the participants provided informed written consent as per the study protocol approved by the Ethics Committee of the Faculty of Medicine of Casablanca.…”

Section: Study Populationmentioning

confidence: 99%

Lack of Association between IFNL3 Polymorphism and Human Papillomavirus Infection and Their Progression in HIV-Infected Women Receiving Antiretroviral Treatment

Ouladlahsen¹,

Bensghir²,

Baba

et al. 2020

Pathobiology

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Background: It has been reported that interferon-λ3 (IFNL3) might influence the pathogenesis and clearance of human papillomavirus (HPV) infection. The impact of IFNL3 singlenucleotide polymorphism (SNP) on HPV infection is currently unknown. The aim of this study was to investigate the association between variants in the IFNL3 region and HPV infection in women with human immunodeficiency virus (HIV) infection. Methods: A total of 236 HIV patients, including 65 HPV-negative and 171 HPV DNA-positive women, were enrolled into this study. The IFNL3 rs12979860 polymorphism was genotyped using a predesigned TaqMan SNP genotyping assay. Results: Data showed no significant differences in genotypes or allele frequencies between the HPV DNA-positive and the HPV-negative women (p > 0.05). After dividing the HPV-positive women according to cytology results into patients with abnormal and normal lesions, the genotype and allele distribution of the SNP did not significantly differ between the 2 groups (p > 0.05). Conclusions: Our results showed that the IFNL3 rs12979860 polymorphism is not a major determinant of the susceptibility to HPV infection and their progression to abnormal cervical lesions in women living with HIV.

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TP53 R72P Polymorphism and Susceptibility to Human Papillomavirus Infection Among Women With Human Immunodeficiency Virus in Morocco: A Case-control Study

Cited by 5 publications

References 29 publications

A Review of Cancer Genetics and Genomics Studies in Africa

A Review of Cancer Genetics and Genomics Studies in Africa

The Effectiveness of P53 Polymorphism in Susceptibility to Human Papillomavirus and Molluscum contagiosum Infections

Lack of Association between IFNL3 Polymorphism and Human Papillomavirus Infection and Their Progression in HIV-Infected Women Receiving Antiretroviral Treatment

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