TP63 (tumor protein p63)

Mattox, Austin K.; Chen, Z; Waes, Carter Van

doi:10.4267/2042/50192

Cited by 1 publication

(1 citation statement)

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“…The P63 with transactivation domain (TAP63) variant is differentially expressed in the brain. [ 8 ] TAP63 has been implicated in heart development and premature aging. [ 9 , 10 ]…”

Section: Introductionmentioning

confidence: 99%

Correlation of progesterone receptors and P63 to the histological grade of meningiomas: Review and significance in an African population

Eluke,

Aniume,

Olusina

et al. 2023

JNRP

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Objectives: Meningiomas, a common neoplasm of the central nervous system, is a widely studied meningeal tumor. According to the World Health Organization (WHO) 2021 classification of meningiomas, there are 15 subtypes that have been grouped into grades 1, 2, and 3. The WHO grade 1 meningiomas are generally grouped as benign while the WHO grades 2 and 3 tumors are grouped as malignant. Progesterone receptors and P63 are common immunohistochemical markers that have proven useful in the diagnosis, grading, and prognostication of many neoplasms such as breast carcinoma, prostate carcinoma, and gastrointestinal tumors in histopathology practice. The application of these immunohistochemical markers to the grading of meningiomas has been reported and their usefulness documented in reports from Africa, Europe, North America, South America, and Asia. This study, therefore, seeks to determine if these findings are applicable to the meningiomas seen in an African population. Materials and Methods: A 10-year review of results and histologically diagnosed cases of meningiomas received in the Department of Morbid Anatomy, University of Nigeria, Enugu. Immunostaining for progesterone receptors (PgRs) and P63 were done and results compared with histologic grades. Results: The three WHO grades of meningioma were assessed in this study. M: F ratio was 1:1.4 and peak age was 41–50 years age range (SD ± 16.54). The majority of the cases were WHO grade 1 (86.1%) while the WHO grades 2 and 3 tumors were 8% and 5.9%, respectively. The fibrous variant was the most common subtype (27.1%). There was no correlation between progesterone receptor and P63 immunopositivity to the WHO grades of meningioma (P = 0.112 and P = 0.138, respectively). Conclusion: Our study showed that progesterone receptors and P63 immunopositivity did not correlate with the WHO grades of meningiomas. This may be due to the predominant variant of meningioma seen in this study. These findings indicate that PgR antagonist may not be an effective alternative for treatment in patients with inoperable meningiomas. Furthermore, P63 immunopositivity may not be a sufficient grading tool for managing meningiomas in our population.

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“…The P63 with transactivation domain (TAP63) variant is differentially expressed in the brain. [ 8 ] TAP63 has been implicated in heart development and premature aging. [ 9 , 10 ]…”

Section: Introductionmentioning

confidence: 99%