2008
DOI: 10.1016/j.tox.2008.07.059
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TPX2 in malignantly transformed human bronchial epithelial cells by anti-benzo[a]pyrene-7,8-diol-9,10-epoxide

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Cited by 21 publications
(13 citation statements)
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“…In cancer biology, TPX2 was initially recognized as an oncogene factor amplified from chromosome 20q11.2 (12). Several studies have demonstrated that TPX2-induced tumor proliferation and inhibition of apoptosis, was upregulated in various tumorous tissue types, including lung, ovarian, pancreatic, breast and oral cancer (2,3,6,(13)(14)(15)(16)(17)(18)(19)(20).…”
Section: Discussionmentioning
confidence: 99%
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“…In cancer biology, TPX2 was initially recognized as an oncogene factor amplified from chromosome 20q11.2 (12). Several studies have demonstrated that TPX2-induced tumor proliferation and inhibition of apoptosis, was upregulated in various tumorous tissue types, including lung, ovarian, pancreatic, breast and oral cancer (2,3,6,(13)(14)(15)(16)(17)(18)(19)(20).…”
Section: Discussionmentioning
confidence: 99%
“…In this study, it was demonstrated that the overexpression of TPX2 in tumor cells caused exuberant amplification of the centrosome, developed aneuploidy and transformation, promotion of tumor proliferation and differentiation, as well as downregulation of tumor apoptosis (2)(3)(4)(5)(6). Conversely, it has also been demonstrated that inhibiting TPX2 and its associated pathways in tumor cells, leads to cancer cell apoptosis.…”
Section: Introductionmentioning
confidence: 86%
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“…Its expression has been associated with highly proliferative tissues. TPX2 can promote tumor cell proliferation, and is involved in cell cycle and apoptosis regulation (2). The suppression of TPX2 expression by RNA intervention technique can cause the defects in microtubule organization during mitosis, as a result the formation of microtubule asters of spindle can not be formed (6).…”
Section: Discussionmentioning
confidence: 99%
“…In recent years, it has been discovered that TPX2 was overexpressed in certain malignant tumors, which resulted in abnormal centrosome amplification, aneuploidy formation and malignant trans formation of cells, promoting proliferation, involved in cell cycle and apoptosis regulation, associated with tumor differentiation and metastasis and recurrence. Blocking its expression could inhibit tumor cell growth and might become a candidate target for tumor treatment (2)(3)(4)(5). The overexpression of TPX2 has been found in saliva gland cancer (3), lung squamous cell carcinoma (4) and breast cancer (5), however, little information exists on its expression in cervical cancer until now.…”
Section: Introductionmentioning
confidence: 99%