Trabecular Bone Score – A non-Invasive Analytical Method to Evaluate Bone Quality Based on Routine Dual-Energy Absorptiometry. Perspectives of Its Use in Clinical Practice

Tsoriev, Timur Т.; Белая, Ж. Е.; Мельниченко, Г. А.

doi:10.18786/2072-0505-2016-44-4-462-476

Cited by 7 publications

(6 citation statements)

References 60 publications

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“…В 2006 г. компанией Med-Imaps запатентована новая методика «TBS iNsight», позво-ляющая оценивать косвенные показатели качества костной ткани -трабекулярный костный индекс (ТКИ) [25]. Пакет программного обеспечения уста-навливается на персональных компьютерах остеоден-ситометров.…”

Section: риск переломов при сд2 -статистические данныеunclassified

Fragility fractures and bone remodeling in type 2 diabetes mellitus

et al. 2017

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Fracture risk is significantly increased in both type 1 and type 2 diabetes and individuals with diabetes experience worse fracture outcomes compared to normoglycemic individuals. Patients with T1DM have decreased bone mineral density (BMD), whereas patients with T2DM demonstrate increased BMD compared to healthy control. The latest studies show increased incidence of low-traumatic fractures in patients with T2DM instead of high bone mineral density (BMD). The risk of osteoporotic fractures in patients with T2DM can be explained by disease complications and increased risk of falls and consequent trauma. However, the most important cause of bone fragility in T2DM is the deterioration in bone microarchitecture, the mechanism of which is not completely understood. High BMD in patients with T2DM does not allow us to use dual-energy X-ray-absorptiometry as a gold standard test for diagnosticsof osteoporosis. Consequently,new risk factors and diagnostic algorithm as well as treatment strategy should be developed for patients with T2DM. In addition to this, some researchers considered that the group of T2DM is geterogenous and physicians might face patients with osteoporosis and mild diabetes that add very little to bone fragility; patients with osteoporosis and moderate or severe diabetes which also affects bone tissue diabetoosteoporosis; and patients without osteoporosis but severe diabetes which cause bone tissue deterioration with the development of diabetic bone disease. New diagnostic tools and algorithm and new experimental research are needed for better understanding bone deterioration in patients with T2DM. This review summarizes our current knowledge on fracture rate, risk factors for fractures and causes of bone deterioration in subjects with T2DM.

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Section: риск переломов при сд2 -статистические данныеunclassified

Fragility fractures and bone remodeling in type 2 diabetes mellitus

et al. 2017

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“…С ее помощью двухмерные изображения трансформируются в трехмерные, при этом МПК остается прежней, но изменяются характеристики расположения трабекул костной ткани (рис. 1) [6]. Высокие баллы Conclusion.…”

Section: актуальностьunclassified

The assessment of trabecular bone score to improve the sensitivity of FRAX in patients with type 2 diabetes mellitus

et al. 2020

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Aim. To estimate the trabecular bone score (TBS) for evaluation of fracture probability in order to make decisions about starting osteoporosis treatment in patients with type 2 diabetes mellitus (T2DM). Materials and methods. We obtained the bone mineral density (BMD) and trabecular bone score (TBS) using dual energy X-ray absorptiometry (iDXA) in patients with T2DM (with and without a history of osteoporotic fractures) versus the control group. Before and after TBS measurements we assessed the ten-year probability of fracture using the Fracture Risk Assessment Tool (FRAX). Results. We enrolled 48 patients with T2DM, including 17 with a history of low-traumatic fracture, 31 patients without fractures and 29 subjects of a control group. BMD was higher in patients with T2DM compared to the control group at L1L4 (mean T-score 0.44, 95% CI -3.2 4.9 vs mean T-score 0.33, 95% CI -2.9 3.0 in a control group p=0.052) and Total Hip (mean T-score 0.51, 95% CI -2.1 3.0 vs mean T-score -0.03, 95% CI -1.4 1.2 in a control group p=0,025). The TBS and 10-year probability of fracture (FRAX) was not different in patients with T2DM versus the control group. However, when the TBS was entered as an additional risk factor, the 10-year probability of fracture became higher in patients with T2DM (10-year probability of fracture in T2DM- 8.68, 95% CI 0.3-25.0 versus 6.68, 95% CI 0.415.0 in control group, p=0.04). Among patients with diabetes with and without fractures the FRAX score was higher in subjects with fractures, but no difference was found in regards to BMD or TBS. Entering BMD and TBS values into the FRAX tool in subjects with diabetes and fractures decreased the FRAX score. However, patients with low-traumatic fractures should be treated for osteoporosis without a BMD, TBS or FRAX assessment. Conclusion. TBS improves the results of FRAX assessment in patients with T2DM and should be entered while evaluating FRAX in patients with T2DM. However, additional research is needed to develop a more sensitive tool to evaluate fracture risk in patients with T2DM.

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“…Лучевая диагностика (денситометрия) В клинической практике основой диагностики остеопороза и прогнозирования риска переломов является измерение минеральной плотности кости (МПК) в поясничном отделе позвоночника, проксимальном отделе бедра и шейке бедренной кости с помощью двухэнергетической рентгеновской абсорбциометрии (DXA) [9,10]. Диагностика остеопороза, согласно критериям ВОЗ, основана на сравнении МПК пациента со средней МПК у молодых взрослых женщин (20-30 лет) с поправкой на расовую принадлежность.…”

Section: диагностика остеопороза при акромегалииunclassified

Bone and joint structural impairments in acromegaly

Tsoriev

Тамерланович²,

Belaya

et al. 2018

Probl Endokrinol (Mosk)

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Elevated serum levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in patients with acromegaly result in intensified bone turnover, as evidenced by increased levels of bone remodeling markers and higher risk of low-traumatic vertebral fractures. However, it was repeatedly observed that bone mineral density (BMD) is normal or even increased in patients with acromegaly (including the active stage of the disease). Increased secretion of GH/IGF-1 causes structural changes in the vertebrae and peripheral joints (osteophyte formation and cartilage hypertrophy), resulting in pain and various deformities of the articular system. These changes are known under the common name «acromegalic arthropathy». It is quite specific complication of the disease. Skeletal complications of acromegaly can persist even after radical treatment, i.e., their course and progression, presumably, do not necessarily depend on the remission level of the underlying disease. This review summarizes the current understanding of the pathophysiology, clinical presentation, diagnosis, and treatment of osteo-articular complications of acromegaly.

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Trabecular Bone Score – A non-Invasive Analytical Method to Evaluate Bone Quality Based on Routine Dual-Energy Absorptiometry. Perspectives of Its Use in Clinical Practice

Cited by 7 publications

References 60 publications

Fragility fractures and bone remodeling in type 2 diabetes mellitus

Fragility fractures and bone remodeling in type 2 diabetes mellitus

The assessment of trabecular bone score to improve the sensitivity of FRAX in patients with type 2 diabetes mellitus

Bone and joint structural impairments in acromegaly

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