Trabecular Bone Score (TBS) in Primary Hyperparathyroidism (PHPT): A Useful Tool?

Santos, Lívia Marcela; Ohe, Monique Nakayama; Pallone, Sthefanie Giovanna; Nacaguma, Isabela Ohki; Kunii, Ilda S.; Silva, Renata Elen Costa da; Vieira, José Gilberto H.; Lazaretti‐Castro, Marise

doi:10.1016/j.jocd.2021.04.001

Cited by 10 publications

(5 citation statements)

References 49 publications

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“…In a study conducted in Brazil in 2021, we have the analysis of 64 individuals with primary hyperparathyroidism before parathyroidectomy, an analysis of vertebral fragility fracture was performed and TBS was able to predict this type of fracture, but TBS (Trabecular Bone Score) Used for Evaluation of Patients with Primary and Secondary… DOI: http://dx.doi.org/10.5772/intechopen.104972 DXA could not. Also, in that study, we have that most the vertebral fractures happened in patients with osteopenia [29]. Other articles also demonstrate the ability of TBS to help predict fragility fracture in individuals with PHPT [30].…”

Section: Why Should We Use the Trabecular Bone Score (Tbs) As An Eval...mentioning

confidence: 65%

TBS (Trabecular Bone Score) Used for Evaluation of Patients with Primary and Secondary Hyperparathyroidism

Santos¹,

Orozco²

2023

Parathyroid Glands - New Aspects

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The increase in parathyroid hormone (PTH) is related to a worse quality of bone mass. Bone densitometry, as an areal bone measurement, is not always able to assess bone microarchitecture. TBS (trabecular bone score) is a software that evaluates bone microarchitecture from the image of the lumbar spine obtained by bone densitometry. The articles have shown an excellent correlation of TBS with the risk of fragility fracture, especially in the individual who has primary hyperparathyroidism. We suggest that TBS may be an excellent method for assessing bone fragility in patients with hyperparathyroidism, especially if TBS is associated with bone densitometry.

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Section: Why Should We Use the Trabecular Bone Score (Tbs) As An Eval...mentioning

confidence: 65%

TBS (Trabecular Bone Score) Used for Evaluation of Patients with Primary and Secondary Hyperparathyroidism

Santos¹,

Orozco²

2023

Parathyroid Glands - New Aspects

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“…и соавт. [ 23 ] было продемонстрировано, что ПГПТ также приводит к нарушению микроархитектоники костной ткани (ТКИ при ПГПТ=1,233 против ТКИ в группе контроля=1,280; p=0,044), а по результатам ROC анализа ТКИ<1,187 был ассоциирован с высоким риском позвоночных переломов. Схожие данные были получены Song А. и соавт.…”

Section: Discussionunclassified

Comparative analysis of bone complications/manifestations in sporadic and MEN1-related primary hyperparathyroidism

Pylina,

Eremkina,

Elfimova

et al. 2024

Probl Endokrinol (Mosk)

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BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) — is a rare syndrome with an autosomal dominant inheritance pattern caused by a mutation in the tumor suppressor gene (MEN1). Parathyroid involvement is the most common MEN1 manifestation resulting in primary hyperparathyroidism (mPHPT). Data on the prevalence and structure of bone disease in mPHPT compared to sporadic one (sPHPT) are often incomplete and contradictory.AIM: The purpose of this study was to compare the severity of bone involvement between mPHPT and sPHPT.MATERIALS AND METHODS: A single-center retrospective study was conducted among young patients in the active phase of PHPT and without prior parathyroidectomy in anamnesis. The analysis included the main parameters of calcium-phosphorus metabolism, bone remodeling markers, as well as an assessment of disease complications. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (DXA) at sites of lumbar spine, femur and radius. Trabecular bone score (TBS) was applied to estimate trabecular microarchitecture. All patients included in the study underwent genetic testing.RESULTS: Group 1 (mPHPT) included 26 patients, and group 2 (sSHPT) included 30 age-matched patients: the median age in group 1 was 34.5 years [25; 39], in group 2 — 30.5 years [28; 36], (p=0.439, U-test). Within group 1, the subgroup 1A (n=21) was formed with patients without other hormone-produced neuroendocrine neoplasms (NEN) in the gastrointestinal tract (GI) and the anterior pituitary gland. The duration of PHPT was comparable in both groups: mPHPT — 1 year [0; 3] versus sPHPT — 1 year [0; 1], (p=0.533, U-test). There were no differences in the main parameters of calcium-phosphorus metabolism, as well as in the prevalence of kidney complications. In the mPHPT group, bone abnormalities were observed significantly more often compared to sPHPT: 54 vs 10% (p=<0.001; F-test). Statistically significant differences were revealed both in BMD and in Z-score values of the femoral neck and total hip, which were lower in the mPHPT group. These differences remained significant when comparing subgroup 1A with sPHPT.CONCLUSION: MEN1-associated PHPT may be accompanied by a more severe decrease in BMD in the femoral neck and total hip compared to sPHPT regardless of the other hormone-producing NEN. Clarifying the role of mutation in the MEN1 gene in these processes requires further study.

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“…In general, compared to control subjects, TBS was reported to be lower in patients with diabetes (42,(57)(58)(59), primary hyperparathyroidism (60)(61)(62)(63)(64), acromegaly (65)(66)(67)(68), anorexia nervosa (69,70), hypercortisolism (71)(72)(73), primary aldosteronism (especially in women) (74), with prolonged GC exposure (75)(76)(77)(78)(79)(80)(81)(82)(83)(84), rheumatoid arthritis and rheumatic disease (85)(86)(87), aromatase inhibition (88), kidney transplant recipients (89), as well as in patients on hemodialysis (90,91). In differentiated thyroid carcinomas, TBS was found to be lower in patients receiving long-term suppressive doses of thyroid-stimulating hormone than in patients receiving shorter-term therapy (92)(93)(94).…”

Section: Tbs and Fracture Risk Prediction In Patients With Diabetes A...mentioning

confidence: 93%

Update on trabecular bone score

Palomo¹,

Muszkat²,

Weiler³

et al. 2022

Archives of Endocrinology and Metabolism

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Trabecular bone score (TBS) is an indirect and noninvasive measure of bone quality. A low TBS indicates degraded bone microarchitecture, predicts osteoporotic fracture, and is partially independent of clinical risk factors and bone mineral density (BMD). There is substantial evidence supporting the use of TBS to assess vertebral, hip, and major osteoporotic fracture risk in postmenopausal women, as well as to assess hip and major osteoporotic fracture risk in men aged > 50 years. TBS complements BMD information and can be used to adjust the FRAX (Fracture Risk Assessment) score to improve risk stratification. While TBS should not be used to monitor antiresorptive therapy, it may be potentially useful for monitoring anabolic therapy. There is also a growing body of evidence indicating that TBS is particularly useful as an adjunct to BMD for fracture risk assessment in conditions associated with increased fracture risk, such as type-2 diabetes, chronic corticosteroid excess, and other conditions wherein BMD readings are often misleading. The interference of abdominal soft tissue thickness (STT) on TBS should also be considered when interpreting these findings because image noise can impact TBS evaluation. A new TBS software version based on an algorithm that accounts for STT rather than BMI seems to correct this technical limitation and is under development. In this paper, we review the current state of TBS, its technical aspects, and its evolving role in the assessment and management of several clinical conditions.

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Trabecular Bone Score (TBS) in Primary Hyperparathyroidism (PHPT): A Useful Tool?

Cited by 10 publications

References 49 publications

TBS (Trabecular Bone Score) Used for Evaluation of Patients with Primary and Secondary Hyperparathyroidism

TBS (Trabecular Bone Score) Used for Evaluation of Patients with Primary and Secondary Hyperparathyroidism

Comparative analysis of bone complications/manifestations in sporadic and MEN1-related primary hyperparathyroidism

Update on trabecular bone score

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