Trabecular Juvenile Ossifying Fibroma: Updated Review of the Literature and Report of an Interesting Case

,; Schoinohoriti, Ourania

doi:10.24966/ohns-010x/100010

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…9 OF is composed of fibrous connective tissue with well-differentiated fibroblasts. 17 Collagen fibers are arranged in a whorled or storiform pattern. 10 Bony spheroids or trabeculae are evenly distributed throughout the fibrous stroma.…”

Section: Discussionmentioning

confidence: 99%

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Spectrum of fibro osseous lesions of jaw: An institutional study

Wagh¹,

Bhavthankar²,

Mandale³

et al. 2023

JOOO

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Fibroosseous lesions (FOLs) of craniofacial complex are poorly defined but pathologically diverse group of conditions. FOLs are represented by variety of disease processes mimicking clinically and histopathologically as neoplasms, developmental dysplastic lesions or inflammatory reactive process leading to difficulties in diagnosis and hence clinicopathological correlation is required.To analyse fibro osseous lesions for demographic details and clinicopathological correlation.26 cases of clinicopathologically diagnosed FOLs such as fibrous dysplasia, ossifying fibroma and cherubism were studied from archives of the Department over a 14yr period (2009 to 2022) and clinicopathologically reviewed.In retrospective study 26 cases of FOLs showed that FOLs are more commonly seen in second decade of life with female predilection and mandible is most commonly affected. Amongst these ossifying fibroma is found to be most common in our study 46% (12/26) as compared to fibrous dysplasia 42% (11/26) and Cherubism 12% (3/26).In the present study FOL were slightly more prevalent in females than male, affecting individuals below 30 years of age. Our data showed several overlapping epidemiological and clinicopathological features. Thus combination of different modalities seems to be necessary for an accurate diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…10 Bony spheroids or trabeculae are evenly distributed throughout the fibrous stroma. 17 Bone is surrounded with osteoblastic rimming. A similar histopathology was noted in present study, JTOF (25%) consisted of lamellar bone with osteoblastic rimming and fibrocellular stroma and bands of cellular osteoid trabeculae.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of fibro osseous lesions of jaw: An institutional study

Wagh¹,

Bhavthankar²,

Mandale³

et al. 2023

JOOO

View full text Add to dashboard Cite

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Comparison of proliferative potential in variants of ossifying fibroma (OF) of craniofacial complex

Zanwar,

Humbe,

A Nandkhedkar

et al. 2024

JDPO

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Comparison of proliferative potential in JTrOF , PsOF and OF of craniofacial complex using CDK4 and pHH3. Fibro-osseous lesions (FOL) refers to a poorly defined diverse group of lesions affecting the jaws and craniofacial complex. This spectrum of lesions includes fibrous dysplasia, cement-osseous dysplasia and two histological variants of ossifying fibroma - Despite benign neoplasms, both the variants of ossifying fibroma are characterized by rapid growth, potential for local invasiveness and a tendency to recur. According to the literature, the recurrence rate of JTrOF is about 20% where as PsOF is from 30-56%. Diagnosis is based on histopathology and imaging of the lesion. Early diagnosis allows for the resection of a smaller lesion , reducing the chance of damage to nearby structures. Various biomarkers such as oncogenes CDK4, MDM2, p53 and α-SMA have been investigated in bone pathology to predict biological behaviour of these lesions for precise treatment planning. Immunohistochemical expression of CDK4 and pHH3 will be assessed in histopathological diagnosed cases of juvenile trabecular ossifying fibroma, psammamatoid ossifying fibroma and conventional ossifying fibroma. The immunohistochemical expression of CDK4 was 100% in JTrOF and PsOF and 60% in OF. The expression of pHH3 was weak and focal in JTrOF and PsOF and also weak in OF. This study reveals the genetic mechanism involved in pathogenesis of aggressive variant of OF. Pre-treatment biopsy and CT scan are necessary for proper diagnosis and treatment planning of the lesion.

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Juvenile Ossifying Fibroma of a 15-Year-old Girl: A Case Report

Awal¹

2021

J Dent Oral Sci

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Juvenile ossifying fibroma is a locally aggressive, benign fibro-osseous tumor. It usually occurs in young children and arises in the maxillofacial region. It has a high recurrence rate. This pathology would be diagnosed and treated as early as possible because of its rapidly progressive and osteolytic nature which may complicate the surgical removal if left untreated over a long period. The present case is diagnosed as Juvenile ossifying fibroma involving the maxilla causing facial deformity, proptosis, and nasal obstruction in a 15-year-old female child.

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Trabecular Juvenile Ossifying Fibroma: Updated Review of the Literature and Report of an Interesting Case

Cited by 3 publications

References 23 publications

Spectrum of fibro osseous lesions of jaw: An institutional study

Spectrum of fibro osseous lesions of jaw: An institutional study

Comparison of proliferative potential in variants of ossifying fibroma (OF) of craniofacial complex

Juvenile Ossifying Fibroma of a 15-Year-old Girl: A Case Report

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