Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma

Sun, Hong; Zhu, Qin; Guo, Ping; Zhang, Yuan; Tighe, Sean; Zhu, Yingting

doi:10.1111/jcmm.14158

Cited by 12 publications

(12 citation statements)

References 72 publications

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“…Elevated VEGF levels in the anterior segment may be the primary cause of the remodeling process in TM tissues (16) . Most of these mediators can induce extracellular matrix remodeling and change functions of cytoskeletal in the TM during glaucoma (27) . Specifically, IL6, which increases in response to oxidative stress, IL8 can modify the permeability of Schlemm's canal endothelial cells and has also been connected to the induction of senescence and the modification of barrier functions of the TM endothelium in pig eyes (28) .…”

Section: Discussionmentioning

confidence: 99%

The Effect of Anabasis articulata Stems Extract on Lowering Intraocular Pressure in the Glaucoma Rat Model(Conference Paper )#

Abdulsahib

2022

IJPS

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High intraocular pressure (IOP) is a recognized risk factor for glaucoma and optic nerve injury, and it is one of the primary causes of vision loss globally. Anabasis articulata (AA) is a desert plant found in Iraq. The extract of AA is used to cure diabetes, fever, eczema, and kidney infections. The aim of the study is to evaluate the antioxidant effect of methanol extract of AA on intraocular pressure in the glaucoma rat model. Forty-two rats were allocated into seven groups, each with six animals:: group 1 (normal), group 2 (control), in which animals were induced to have elevated IOP by betamethasone suspension injection, groups 3,4 and 5 for evaluating the effect of 50,100 and 150 mg/kg/day of the tested extract, respectively, and the remaining two groups (group 6 and 7) for evaluating oral acetazolamide and topical timolol 0.5% respectively. Betamethasone was used for the induction. Measure the IOP every 2 days for 2 weeks. The daily dose of AA extract (50 mg/kg/day) for 6 days significantly reduces intraocular pressure (p ? 0.05), from (34.23± 0.58) to (32.83± 1.38) mmHg when compared with the control group. In group 4, IOP decreased significantly from (35.5±1.37) to (31.35±0.40) mmHg (p ? 0.05) after 1 week of treatment. In group 5, the significant (p? 0.001) IOP reduction from (35.66±0.39) to (31.88±0.74) mmHg started on day 6 and continued until the end of the experiment, reaching (24.53±0.53) mmHg (p? 0.001). The antioxidant and anti-angiogenic properties of AA make it a promising adjuvant treatment for glaucoma.

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Section: Discussionmentioning

confidence: 99%

The Effect of Anabasis articulata Stems Extract on Lowering Intraocular Pressure in the Glaucoma Rat Model(Conference Paper )#

Abdulsahib

2022

IJPS

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“…Current evidence shows that there is a population of adult stem cells in the Schwalbe’s ring and the anterior trabecular meshwork. [ 71 ] These adult stem cells play a crucial role in tissue repair and may also be expanded in vitro for tissue regeneration. Restoration of aqueous humor flow in mouse models following transplantation of iPSC-derived trabecular meshwork cells has been reported.…”

Section: Investigational Glaucoma Medicationsmentioning

confidence: 99%

Newer advances in medical management of glaucoma

Chakrabarti

Mohan

Nazm

et al. 2022

Indian Journal of Ophthalmology

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The burden of irreversible vision loss from Glaucoma continues to rise. While the disease pathogenesis is not well understood, intraocular pressure (IOP) is the only modifiable risk factor identified to prevent glaucomatous vision loss. Medical management remains the first-line of treatment in most adult glaucomas and the evolution of medical therapy for glaucoma has followed an exponential curve. This review tracks the rapid development of new medications and drug delivery systems in the recent years. Introduction of Rho kinase inhibitors with an entirely new mechanism of action from that of the currently used anti glaucoma medications has been a significant milestone. Latanoprostene Bunod is a novel, single molecule which provides two active metabolites that work through two different pathways for reducing intra ocular pressure. Bimatoprost implants and travoprost punctum plugs attempt to ease chronic medication use in glaucoma patients. Nanotechnology is an evolving route of drug delivery. Role of cannabinoids in medical management of glaucoma remain equivocal. The relatively short term effect on IOP, the risks of developing tolerance and side effects impacting patients’ neurocognitive health greatly outweigh the potential benefit. Research on Latrunculin B, Adenosine receptor agonists, Specific gene silencing and Stem cell therapy are poised to make an impact on glaucoma treatment. While there is some evidence to support the role of Brimonidine in neuroprotection, further research is needed to clarify the role of Memantine and Neurotrophins. Evidence for benefit from dietary supplementation with Alpha lipoic acid, Forskolin , and Ginko Biloba is limited

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“…Glaucoma causes irreversible blindness worldwide, linked to pathogenesis in TM cells [35]. It is estimated that by 2020, 80 million patients will suffer from glaucoma and 11.2 million of those people will develop bilateral blindness [36][37][38].…”

Section: Glaucomamentioning

confidence: 99%

Human Trabecular Meshwork Progenitors

et al. 2019

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Trabecular meshwork (TM) cells are a group of progenitors that have the ability to become adipocytes, chondrocytes and endothelial cells. Therefore, those adult corneal progenitors may be used as an effective therapy for trabecular meshwork diseases such as glaucoma, corneal endothelial dysfunctions such as blindness due to corneal endothelial dysfunction, and similar diseases. In order to promote the understanding of human trabecular meshwork progenitors, this article reviews human trabecular meshwork progenitor therapy and discusses its potential applications for curing human eye blindness.

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Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma

Cited by 12 publications

References 72 publications

The Effect of Anabasis articulata Stems Extract on Lowering Intraocular Pressure in the Glaucoma Rat Model(Conference Paper )#

The Effect of Anabasis articulata Stems Extract on Lowering Intraocular Pressure in the Glaucoma Rat Model(Conference Paper )#

Newer advances in medical management of glaucoma

Human Trabecular Meshwork Progenitors

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