Trabecular pattern in the mandible as bone fracture predictor

Jonasson, Grethe; Alstad, Torgny; Vahedi, Flor; Bosæus, Ingvar; Lissner, Lauren; Hakeberg, Magnus

doi:10.1016/j.tripleo.2009.05.018

Cited by 20 publications

(15 citation statements)

References 28 publications

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“…In the present investigation, previous fracture may be more relevant than any BMD measurement. Earlier results , stating that the mandibular trabecular pattern was a better correlate of fracture than was BMD, as it identified 48% of all previous fractures compared with the 19% identified using BMD, may support this. Furthermore, the protective effect of dense trabeculation and the excess risk for sparse trabeculation have been demonstrated in prospective research in which the fracture year was known, all fractures were hospital‐verified and sparse trabeculation was found in 70% of the fracture cases before the fracture date .…”

Section: Discussionmentioning

confidence: 77%

Mandibular trabecular bone as fracture indicator in 80‐year‐old men and women

Hassani-Nejad

Ahlqwist

Hakeberg

et al. 2013

European J Oral Sciences

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The objective of the present study was to compare assessments of the mandibular bone as fracture risk indicators for 277 men and women. The mandibular trabecular bone was evaluated in periapical radiographs, using a visual index, as dense, mixed dense and sparse, or sparse. Bone texture was analysed using a computer-based method in which the number of transitions from trabeculae to intertrabecular spaces was calculated. The sum of the sizes and intensities of the spaces between the trabeculae was calculated using Jaw-X software. Women had a statistically significantly greater number of fractures and a higher frequency of sparse mandibular bone. The OR for having suffered a fracture with visually sparse trabecular bone was highest for the male group (OR = 5.55) and lowest for the female group (OR = 3.35). For bone texture as an indicator of previous fracture, the OR was significant for the female group (OR = 2.61) but not for the male group, whereas the Jaw-X calculations did not differentiate between fractured and non-fractured groups. In conclusion, all bone-quality assessments showed that women had a higher incidence of sparse trabecular bone than did men. Only the methods of visual assessment and trabecular texture were significantly correlated with previous bone fractures.

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Section: Discussionmentioning

confidence: 77%

Mandibular trabecular bone as fracture indicator in 80‐year‐old men and women

Hassani-Nejad

Ahlqwist

Hakeberg

et al. 2013

European J Oral Sciences

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“…5,6 Also the risk is higher in patients with sparse alveolar trabecular pattern. 7-9 The structure of the trabecular bone is critical for the stability of an endosseous implant and mini-implant. 10 Trabecular bone structure can be evaluated using different approaches.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the changes in alveolar bone quality after fixed orthodontic therapy: A trabecular structure analysis

Haghnegahdar

Najafi

Sabet

et al. 2016

J Dent Res Dent Clin Dent Prospects

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Background. Tooth displacement changes the periodontium. The aim of orthodontic treatment is desired tooth movement with minimum side effects on the alveolar bone quality. The aim of the present study was to assess changes of alveolar trabeculation in children, young adults and adults and the two genders.Methods. In this cross-sectional study, 63 patients who had been treated in Department of Orthodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran, were chosen with convenient sampling method. They were divided into three groups based on their age. Their digitized panoramic radiographs (PRs) were evaluated at six interdental sites from the mesial aspect of the mandibular second molars to the distal aspect of the mandibular first premolars using a visual index. The trabeculation pattern was assigned as either dense (score 3), dense-sparse (score 2) or sparse (score 1). Data were imported to SPSS. Mean of the scores before treatment (score B) and mean of them after treatment (score A) were compared for each group with paired t-test. Changes between score B and sore A of the groups were compared using one-way ANOVA and post hoc tests.Results. Mean score A was significantly higher than mean score B in children (P = 0.001). In contrast, mean score A was significantly lower than mean score B in young adults (P = 0.003).Conclusion. Orthodontists should be cautious when treating young adults and adults regarding the probable, yet possibly temporary, negative effects of orthodontic therapy on the alveolar bone quality.

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“…It has been suggested that patients with a history of osteoporotic fractures tend to have increased mandibular bone loss and relevant trabecular micro-structural changes [22] . Additionally, a dense trabecular pattern in the mandibular alveolar process has been proven to be a reliable sign of normal BMD in dentate middle-aged subjects whereas a sparse trabecular pattern indicates osteopenia [23] . In developed countries, a large proportion of the population visits dentists annually, and dental radiographs are performed routinely.…”

Section: Introductionmentioning

confidence: 99%

“…In developed countries, a large proportion of the population visits dentists annually, and dental radiographs are performed routinely. Thus, researchers worldwide have recently tried to develop methods for using the jawbones, especially the mandible, to predict skeletal BMD [23] . The mandibular condyle, one important section of the mandible, is one of the most common sites of OA [24] .…”

Section: Introductionmentioning

confidence: 99%

Dose-dependent effects of genistein on bone homeostasis in rats' mandibular subchondral bone

Xing

Wang

et al. 2011

Acta Pharmacol Sin

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Aim: To investigate the effect of genistein on bone homeostasis in mandibular subchondral bone of rats. Methods: Female SD rats were administered with genistein (10 and 50 mg/kg) or placebo by oral gavage for 6 weeks. Then the animals were sacrificed, and histomorphology and micro-structure of mandibular condyle were examined using HE staining and micro-CT analysis, respectively. The expression levels of alkaline phosphatase (ALP), osteocalcin (OC), osteoprotegerin (OPG), the receptor activator of nuclear factor κB ligand (RANKL) and estrogen receptors (ERs) in mandibular condyle were detected using real-time PCR. Cultured osteoblasts were prepared from rat mandibular condyle for in in vitro study. The cells were treated with genistein (10 -7 or 10 -4 mol/L) for 48 h. The expression of the bone homeostasis-associated factors and estrogen receptors (ERs) was detected using realtime PCR, and ER silencing was performed. Results: At both the low-and high-doses, genistein significantly increased the bone mineral density (BMD) and bone volume, and resulted in thicker subchondral trabecular bone in vivo. In both in vivo and in vitro study, the low-dose genistein significantly increased the expression of ALP, OC and OPG, but decreased the expression of RANKL and the RANKL/OPG ratio. The high-dose genistein decreased the expression of all these bone homeostasis-associated factors. Both the low and high doses of genistein significantly increased the expression of ERβ, while ERα expression was increased by the low dose genistein and decreased by the high dose genistein. ERβ silencing abrogated most of the effects of genistein treatment. Conclusion: In rat mandibular condylar subchondral bone, low-dose genistein increases bone formation and inhibit bone resorption, while excess genistein inhibits both bone formation and resorption. The effects of genistein were predominantly mediated through ERβ.

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Trabecular pattern in the mandible as bone fracture predictor

Cited by 20 publications

References 28 publications

Mandibular trabecular bone as fracture indicator in 80‐year‐old men and women

Mandibular trabecular bone as fracture indicator in 80‐year‐old men and women

Assessment of the changes in alveolar bone quality after fixed orthodontic therapy: A trabecular structure analysis

Dose-dependent effects of genistein on bone homeostasis in rats' mandibular subchondral bone

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